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    Dmrta2 doublesex and mab-3 related transcription factor like family A2 [ Mus musculus (house mouse) ]

    Gene ID: 242620, updated on 12-May-2024

    Summary

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    Official Symbol
    Dmrta2provided by MGI
    Official Full Name
    doublesex and mab-3 related transcription factor like family A2provided by MGI
    Primary source
    MGI:MGI:2653629
    See related
    Ensembl:ENSMUSG00000047143 AllianceGenome:MGI:2653629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dmrt5
    Summary
    Enables identical protein binding activity and sequence-specific DNA binding activity. Acts upstream of or within nervous system development and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human DMRTA2 (DMRT like family A2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 8.1), CNS E14 (RPKM 5.1) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dmrta2 in Genome Data Viewer
    Location:
    4 C7; 4 51.37 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (109835222..109840896)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (109977989..109983691)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase inhibitor 2C Neighboring gene Fas-associated factor 1 Neighboring gene STARR-seq mESC enhancer starr_11075 Neighboring gene STARR-seq mESC enhancer starr_11076 Neighboring gene doublesex and mab-3 related transcription factor like family A2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_11077 Neighboring gene STARR-seq mESC enhancer starr_11078 Neighboring gene predicted gene, 33070 Neighboring gene ELAV like RNA binding protein 4 Neighboring gene predicted gene, 54251

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1. Young FI, et al. Proc Natl Acad Sci U S A, 2017 Jul 11. PMID 28655839, Free PMC Article
    2. Involvement of doublesex and mab-3-related transcription factors in human female germ cell development demonstrated by xenograft and interference RNA strategies. Poulain M, et al. Mol Hum Reprod, 2014 Oct. PMID 25082981
    3. Doublesex and mab-3-related transcription factor 5 promotes midbrain dopaminergic identity in pluripotent stem cells by enforcing a ventral-medial progenitor fate. Gennet N, et al. Proc Natl Acad Sci U S A, 2011 May 31. PMID 21576465, Free PMC Article
    4. Dmrt5, a Novel Neurogenic Factor, Reciprocally Regulates Lhx2 to Control the Neuron-Glia Cell-Fate Switch in the Developing Hippocampus. Muralidharan B, et al. J Neurosci, 2017 Nov 15. PMID 29025924, Free PMC Article
    5. The function of Dmrt genes in vertebrate development: it is not just about sex. Hong CS, et al. Dev Biol, 2007 Oct 1. PMID 17720152

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis.
      Title: Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis.
    2. Study suggests that DMRT3/5 function with EMX2 in positioning the pallial-subpallial boundary by antagonizing the ventral homeobox transcription factor GSX2.
      Title: DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors.
    3. Finely tuned levels of DMRT5, together with DMRT3, regulate patterning of the cerebral cortex.
      Title: DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation.
    4. there is a link between Dmrta2 modulation of Hes1 expression and the maintenance of neural progenitor cells during cortical development
      Title: The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.
    5. Dmrt5 is neurogenic, and reciprocally regulated by Lhx2; loss of either factor promotes gliogenesis.
      Title: Dmrt5, a Novel Neurogenic Factor, Reciprocally Regulates Lhx2 to Control the Neuron-Glia Cell-Fate Switch in the Developing Hippocampus.
    6. Dmrt5 is a novel Wnt-dependent transcription factor required for early cortical development
      Title: The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals.
    7. data suggest that Dmrta2 plays pivotal roles in the early development of the telencephalon via the formation of the cortical hem, a source of Wnts, and also in the maintenance of neural progenitors as a downstream of the Wnt pathway
      Title: The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex.
    8. Dmrt5 is an important player in ventral mesencephalic neural fate specification
      Title: Doublesex and mab-3-related transcription factor 5 promotes midbrain dopaminergic identity in pluripotent stem cells by enforcing a ventral-medial progenitor fate.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cerebral cortex regionalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sex differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stem cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    doublesex- and mab-3-related transcription factor A2
    Names
    doublesex- and mab-3-related transcription factor 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172296.2 → NP_758500.2  doublesex- and mab-3-related transcription factor A2

      See identical proteins and their annotated locations for NP_758500.2

      Status: VALIDATED

      Source sequence(s)
      AI465212, AL627188, AY145837, CJ172393
      Consensus CDS
      CCDS18469.1
      UniProtKB/Swiss-Prot
      A2A9A2, Q8CFF8
      Related
      ENSMUSP00000060441.4, ENSMUST00000061187.4
      Conserved Domains (2) summary
      cd14418
      Location:308 → 349
      CUE_DMA_DMRTA2; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2)
      pfam00751
      Location:65 → 111
      DM; DM DNA binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      109835222..109840896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503093.5 → XP_006503156.1  doublesex- and mab-3-related transcription factor A2 isoform X1

      See identical proteins and their annotated locations for XP_006503156.1

      UniProtKB/Swiss-Prot
      A2A9A2, Q8CFF8
      Conserved Domains (2) summary
      cd14418
      Location:308 → 349
      CUE_DMA_DMRTA2; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2)
      pfam00751
      Location:65 → 111
      DM; DM DNA binding domain

    2. XM_006503094.5 → XP_006503157.1  doublesex- and mab-3-related transcription factor A2 isoform X1

      See identical proteins and their annotated locations for XP_006503157.1

      UniProtKB/Swiss-Prot
      A2A9A2, Q8CFF8
      Conserved Domains (2) summary
      cd14418
      Location:308 → 349
      CUE_DMA_DMRTA2; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2)
      pfam00751
      Location:65 → 111
      DM; DM DNA binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A9A2.1 GenPept UniProtKB/Swiss-Prot:A2A9A2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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