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    YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [ Homo sapiens (human) ]

    Gene ID: 7529, updated on 11-Apr-2024

    Summary

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    Official Symbol
    YWHABprovided by HGNC
    Official Full Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein betaprovided by HGNC
    Primary source
    HGNC:HGNC:12849
    See related
    Ensembl:ENSG00000166913 MIM:601289; AllianceGenome:HGNC:12849
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HS1; GW128; YWHAA; KCIP-1; HEL-S-1
    Summary
    This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 158.2), lymph node (RPKM 85.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See YWHAB in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (44885705..44908532)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (46621568..46644395)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43514346..43537173)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:43380582-43381129 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:43385377-43386576 Neighboring gene potassium two pore domain channel subfamily K member 15 Neighboring gene regulating synaptic membrane exocytosis 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:43401277-43401777 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:43405721-43405858 Neighboring gene piggyBac transposable element derived 4 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12948 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:43514076-43514692 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:43545042-43545542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:43545543-43546043 Neighboring gene poly(A) binding protein cytoplasmic 1 like Neighboring gene uncharacterized LOC124904912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17941 Neighboring gene translocase of outer mitochondrial membrane 34

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Integrated bioinformatic analysis reveals YWHAB as a novel diagnostic biomarker for idiopathic pulmonary arterial hypertension. Wang T, et al. J Cell Physiol, 2019 May. PMID 30317584
    2. 14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface. Karlberg T, et al. Nat Commun, 2018 Sep 17. PMID 30224724, Free PMC Article
    3. 14-3-3β Depletion Drives a Senescence Program in Glioblastoma Cells Through the ERK/SKP2/p27 Pathway. Seo SB, et al. Mol Neurobiol, 2018 Feb. PMID 28116547
    4. 14-3-3β protein expression in eosinophilic meningitis caused by Angiostrongylus cantonensis infection. Tsai HC, et al. BMC Res Notes, 2014 Feb 20. PMID 24555778, Free PMC Article
    5. Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins. Kleppe R, et al. FEBS Lett, 2014 Jan 3. PMID 24269229

    See all (435) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-375-3p targets YWHAB to attenuate intestine injury in neonatal necrotizing enterocolitis.
      Title: miR-375-3p targets YWHAB to attenuate intestine injury in neonatal necrotizing enterocolitis.
    2. 14-3-3beta isoform is specifically acetylated at Lys51 during differentiation to the osteogenic lineage.
      Title: 14-3-3β isoform is specifically acetylated at Lys51 during differentiation to the osteogenic lineage.
    3. Circ SMARCA5 Inhibited Tumor Metastasis by Interacting with SND1 and Downregulating the YWHAB Gene in Cervical Cancer.
      Title: Circ SMARCA5 Inhibited Tumor Metastasis by Interacting with SND1 and Downregulating the YWHAB Gene in Cervical Cancer.
    4. Compensatory Protection of Thioredoxin-Deficient Cells from Etoposide-Induced Cell Death by Selenoprotein W via Interaction with 14-3-3.
      Title: Compensatory Protection of Thioredoxin-Deficient Cells from Etoposide-Induced Cell Death by Selenoprotein W via Interaction with 14-3-3.
    5. The regulatory protein 14-3-3beta binds to the IQ motifs of myosin-IC independent of phosphorylation.
      Title: The regulatory protein 14-3-3β binds to the IQ motifs of myosin-IC independent of phosphorylation.
    6. YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization and its activity.
      Title: YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization.
    7. YWHAB was identified and validated in association with pulmonary arterial hypertension progression, which might serve as a biomarker and/or therapeutic target for pulmonary arterial hypertension.
      Title: Integrated bioinformatic analysis reveals YWHAB as a novel diagnostic biomarker for idiopathic pulmonary arterial hypertension.
    8. the interaction of lncRNA RP11-732M18.3 with 14-3-3beta/alpha increases the degradation of the p21 protein. lncRNA RP11-732M18.3 promoted the recruitment of ubiquitin-conjugating enzyme E2 E1 to 14-3-3beta/alpha and the binding of 14-3-3beta/alpha with ubiquitin-conjugating enzyme E2 E1 (UBE2E1) promoted the degradation of p21.
      Title: The binding of lncRNA RP11-732M18.3 with 14-3-3 β/α accelerates p21 degradation and promotes glioma growth.
    9. 14-3-3 beta and gamma function as positive regulators of GR transactivation and glucocorticoid-mediated hepatic gluconeogenesis.
      Title: Roles of 14-3-3β and γ in regulation of the glucocorticoid receptor transcriptional activation and hepatic gluconeogenesis.
    10. findings advance our understanding of how phosphorylation of lipin 1beta phosphatidate phosphatase regulates its interaction with 14-3-3beta protein and intracellular localization and uncover a mechanism by which CKII regulates cellular physiology.
      Title: Casein kinase II-mediated phosphorylation of lipin 1β phosphatidate phosphatase at Ser-285 and Ser-287 regulates its interaction with 14-3-3β protein.
    Submit: New GeneRIF Correction See all GeneRIFs (57)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of WASF2 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed
    Vpr vpr HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells PubMed
    vpr Interaction of HIV-1 Vpr with human 14-3-3 protein is presumed based on homology to yeast DNA damage checkpoint protein rad25 which enhances HIV-1 Vpr-induced G2 arrest in vitro, most likely through the inhibition of Cdc25 PubMed
    integrase gag-pol HIV-1 IN is identified to have a physical interaction with 14-3-3 protein beta/alpha (YWHAB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding HDA PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphoserine residue binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic sequestering of protein IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    14-3-3 protein beta/alpha
    Names
    14-3-3 alpha
    epididymis secretory protein Li 1
    protein 1054
    protein kinase C inhibitor protein-1
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003404.5 → NP_003395.1  14-3-3 protein beta/alpha

      See identical proteins and their annotated locations for NP_003395.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AA845374, AK292717, AL008725, DB443535
      Consensus CDS
      CCDS13339.1
      UniProtKB/Swiss-Prot
      A8K9K2, E1P616, P31946
      UniProtKB/TrEMBL
      B5BU24, V9HWD6
      Related
      ENSP00000361930.3, ENST00000372839.7
      Conserved Domains (1) summary
      cd10022
      Location:4 → 232
      14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

    2. NM_139323.4 → NP_647539.1  14-3-3 protein beta/alpha

      See identical proteins and their annotated locations for NP_647539.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AA845374, AL008725, BC001359, DB443535
      Consensus CDS
      CCDS13339.1
      UniProtKB/Swiss-Prot
      A8K9K2, E1P616, P31946
      UniProtKB/TrEMBL
      B5BU24, V9HWD6
      Related
      ENSP00000300161.4, ENST00000353703.9
      Conserved Domains (1) summary
      cd10022
      Location:4 → 232
      14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      44885705..44908532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028040.2 → XP_016883529.1  14-3-3 protein beta/alpha isoform X1

      UniProtKB/TrEMBL
      Q4VY19
      Related
      ENSP00000394729.1, ENST00000428262.1
      Conserved Domains (1) summary
      cl02098
      Location:4 → 100
      14-3-3; 14-3-3 domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      46621568..46644395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323962.1 → XP_054179937.1  14-3-3 protein beta/alpha isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31946.3 GenPept UniProtKB/Swiss-Prot:P31946

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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