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    Zranb3 zinc finger, RAN-binding domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 226409, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zranb3provided by MGI
    Official Full Name
    zinc finger, RAN-binding domain containing 3provided by MGI
    Primary source
    MGI:MGI:1918362
    See related
    Ensembl:ENSMUSG00000036086 AllianceGenome:MGI:1918362
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AH2; C730006D09; 4933425L19Rik
    Summary
    Predicted to enable ATP-dependent DNA/DNA annealing activity; K63-linked polyubiquitin modification-dependent protein binding activity; and endodeoxyribonuclease activity. Predicted to be involved in several processes, including DNA metabolic process; DNA rewinding; and negative regulation of DNA recombination. Predicted to be located in nucleoplasm. Predicted to be active in nuclear replication fork. Orthologous to human ZRANB3 (zinc finger RANBP2-type containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 1.7), limb E14.5 (RPKM 1.0) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 E3; 1 55.8 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (127881916..128030799, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (127954179..128103053, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:129726872-129727109 Neighboring gene mitogen-activated protein kinase kinase kinase 19 Neighboring gene STARR-positive B cell enhancer ABC_E7742 Neighboring gene RAB3 GTPase activating protein subunit 1 Neighboring gene predicted gene 28800 Neighboring gene STARR-seq mESC enhancer starr_02154 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129912788-129913088 Neighboring gene My020 protein Neighboring gene STARR-seq mESC enhancer starr_02156 Neighboring gene ribosomal protein L28, pseudogene 1 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129973654-129973955 Neighboring gene STARR-positive B cell enhancer ABC_E991 Neighboring gene STARR-positive B cell enhancer mm9_chr1:129999606-129999907 Neighboring gene male-enhanced antigen 1 pseudogene Neighboring gene R3H domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_02158 Neighboring gene microRNA 128-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Smarcal1 and Zranb3 Protect Replication Forks from Myc-Induced DNA Replication Stress. Puccetti MV, et al. Cancer Res, 2019 Apr 1. PMID 30610086, Free PMC Article
    2. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    3. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA/DNA annealing activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA rewinding ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork reversal ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA annealing helicase and endonuclease ZRANB3
    Names
    annealing helicase 2
    zinc finger Ran-binding domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285945.1 → NP_001272874.1  DNA annealing helicase and endonuclease ZRANB3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131995, AK016921, BC066035
      UniProtKB/Swiss-Prot
      Q6NZP1
      UniProtKB/TrEMBL
      Q9D3Z7
      Conserved Domains (6) summary
      smart00547
      Location:625 → 647
      ZnF_RBZ; Zinc finger domain
      smart00487
      Location:33 → 216
      DEXDc; DEAD-like helicases superfamily
      cd00046
      Location:59 → 194
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00085
      Location:978 → 1043
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:625 → 644
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00271
      Location:334 → 439
      Helicase_C; Helicase conserved C-terminal domain

    2. NM_001357573.1 → NP_001344502.1  DNA annealing helicase and endonuclease ZRANB3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC129545, AC131995
      Consensus CDS
      CCDS35697.1
      UniProtKB/Swiss-Prot
      Q148X9, Q6NZP1, Q8BJJ3, Q8BWT6
      Related
      ENSMUSP00000108157.3, ENSMUST00000112538.4
      Conserved Domains (4) summary
      smart00547
      Location:621 → 643
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:7 → 477
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:974 → 1039
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:621 → 640
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    3. NM_027678.3 → NP_081954.1  DNA annealing helicase and endonuclease ZRANB3 isoform 1

      See identical proteins and their annotated locations for NP_081954.1

      Status: VALIDATED

      Source sequence(s)
      AC129545, AC131995, AK084943, BC066035
      Consensus CDS
      CCDS35697.1
      UniProtKB/Swiss-Prot
      Q148X9, Q6NZP1, Q8BJJ3, Q8BWT6
      Related
      ENSMUSP00000083806.6, ENSMUST00000086614.12
      Conserved Domains (4) summary
      smart00547
      Location:621 → 643
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:7 → 477
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:974 → 1039
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:621 → 640
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      127881916..128030799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529408.2 → XP_006529471.1  DNA annealing helicase and endonuclease ZRANB3 isoform X1

      Conserved Domains (5) summary
      smart00547
      Location:625 → 647
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:11 → 481
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:1025 → 1090
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:625 → 644
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:41 → 260
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1

    2. XM_036163815.1 → XP_036019708.1  DNA annealing helicase and endonuclease ZRANB3 isoform X3

      Conserved Domains (5) summary
      smart00547
      Location:561 → 583
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:1 → 417
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:961 → 1026
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:561 → 580
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:1 → 196
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1

    3. XM_006529411.5 → XP_006529474.1  DNA annealing helicase and endonuclease ZRANB3 isoform X2

      See identical proteins and their annotated locations for XP_006529474.1

      Conserved Domains (5) summary
      smart00547
      Location:621 → 643
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:7 → 477
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:1021 → 1086
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:621 → 640
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:37 → 256
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1

    4. XM_006529410.2 → XP_006529473.1  DNA annealing helicase and endonuclease ZRANB3 isoform X2

      See identical proteins and their annotated locations for XP_006529473.1

      Conserved Domains (5) summary
      smart00547
      Location:621 → 643
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:7 → 477
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:1021 → 1086
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:621 → 640
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:37 → 256
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1

    5. XM_036163817.1 → XP_036019710.1  DNA annealing helicase and endonuclease ZRANB3 isoform X3

      Conserved Domains (5) summary
      smart00547
      Location:561 → 583
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:1 → 417
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:961 → 1026
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:561 → 580
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:1 → 196
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1

    6. XM_030253114.1 → XP_030108974.1  DNA annealing helicase and endonuclease ZRANB3 isoform X3

      Conserved Domains (5) summary
      smart00547
      Location:561 → 583
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:1 → 417
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:961 → 1026
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:561 → 580
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:1 → 196
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1

    7. XM_006529409.1 → XP_006529472.1  DNA annealing helicase and endonuclease ZRANB3 isoform X2

      See identical proteins and their annotated locations for XP_006529472.1

      Conserved Domains (5) summary
      smart00547
      Location:621 → 643
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:7 → 477
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:1021 → 1086
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:621 → 640
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:37 → 256
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1

    8. XM_030253115.1 → XP_030108975.1  DNA annealing helicase and endonuclease ZRANB3 isoform X4

      Conserved Domains (5) summary
      smart00547
      Location:561 → 583
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:1 → 417
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:914 → 979
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:561 → 580
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:1 → 196
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1

    9. XM_036163819.1 → XP_036019712.1  DNA annealing helicase and endonuclease ZRANB3 isoform X5

      Conserved Domains (4) summary
      smart00547
      Location:290 → 312
      ZnF_RBZ; Zinc finger domain
      cd00085
      Location:690 → 755
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:290 → 309
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18793
      Location:9 → 115
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases

    10. XM_006529416.3 → XP_006529479.1  DNA annealing helicase and endonuclease ZRANB3 isoform X6

      See identical proteins and their annotated locations for XP_006529479.1

      UniProtKB/TrEMBL
      Q8BUI4, Q9D3Z7
      Conserved Domains (2) summary
      COG0553
      Location:11 → 481
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18010
      Location:41 → 260
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1

    RNA

    1. XR_001784077.2 RNA Sequence

    2. XR_004941832.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NZP1.1 GenPept UniProtKB/Swiss-Prot:Q6NZP1

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