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    PRKY protein kinase Y-linked (pseudogene) [ Homo sapiens (human) ]

    Gene ID: 5616, updated on 11-Apr-2024

    Summary

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    Official Symbol
    PRKYprovided by HGNC
    Official Full Name
    protein kinase Y-linked (pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:9444
    See related
    Ensembl:ENSG00000293442 MIM:400008; AllianceGenome:HGNC:9444
    Gene type
    pseudo
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRKYP; PRKXP3
    Summary
    This gene is similar to the protein kinase, X-linked gene in the pseudoautosomal region of the X chromosome. The gene is classified as a transcribed pseudogene because it has lost a coding exon that results in all transcripts being candidates for nonsense-mediated decay (NMD) and unlikely to express a protein. Abnormal recombination between this gene and a related gene on chromosome X is a frequent cause of XX males and XY females. [provided by RefSeq, Jul 2010]
    Expression
    Broad expression in skin (RPKM 2.8), prostate (RPKM 1.9) and 19 other tissues See more
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    Genomic context

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    Location:
    Yp11.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (7273972..7381547)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (6926299..7033870)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (7142013..7249588)

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene transducin beta like 1 Y-linked Neighboring gene family with sequence similarity 199, Y-linked, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrY:6931456-6932655 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrY:6975278-6976477 Neighboring gene G protein-coupled receptor 143 Y-linked pseudogene Neighboring gene RN7SK pseudogene 282 Neighboring gene RNA, U6 small nuclear 941, pseudogene Neighboring gene RNA, U6 small nuclear 521, pseudogene Neighboring gene uncharacterized LOC107987338

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A selective difference between human Y-chromosomal DNA haplotypes. Jobling MA, et al. Curr Biol, 1998 Dec 17-31. PMID 9889101
    2. High-resolution fluorescence in situ hybridization of human Y-linked genes on released chromatin. Gläser B, et al. Chromosome Res, 1997 Feb. PMID 9088640
    3. Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females. Schiebel K, et al. Hum Mol Genet, 1997 Oct. PMID 9302280
    4. The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability. Klink A, et al. Hum Mol Genet, 1995 May. PMID 7633447
    5. FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-->q13. Schiebel K, et al. Cytogenet Cell Genet, 1997. PMID 9154127

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of genetic testing. (HuGE Navigator)
      Title: Perioperative genomic profiles using structure-specific oligonucleotide probes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein kinase A signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_028062.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AA767129, AC007284, AC010143, BC074852, Y15801
      Related
      ENST00000528056.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      7273972..7381547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      6926299..7033870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_002760.3: Suppressed sequence

      Description
      NM_002760.3: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43930.1 GenPept UniProtKB/Swiss-Prot:O43930

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Miscellaneous