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    Cpxm2 carboxypeptidase X, M14 family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 55987, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cpxm2provided by MGI
    Official Full Name
    carboxypeptidase X, M14 family member 2provided by MGI
    Primary source
    MGI:MGI:1926006
    See related
    Ensembl:ENSMUSG00000030862 AllianceGenome:MGI:1926006
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cpx2; CPX-2; 4632435C11Rik
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be located in extracellular region. Is expressed in blood vessel; nasal cavity epithelium; and skin. Orthologous to human CPXM2 (carboxypeptidase X, M14 family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 11.7), genital fat pad adult (RPKM 8.2) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cpxm2 in Genome Data Viewer
    Location:
    7 F3; 7 75.6 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (131634416..131756483, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (132032687..132154765, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34725 Neighboring gene G protein-coupled receptor 26 Neighboring gene STARR-seq mESC enhancer starr_20288 Neighboring gene STARR-seq mESC enhancer starr_20291 Neighboring gene carbohydrate sulfotransferase 15 Neighboring gene STARR-positive B cell enhancer ABC_E8215 Neighboring gene predicted gene 10584 Neighboring gene predicted gene, 34908

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension. Grabowski K, et al. Hypertens Res, 2022 Feb. PMID 34916661, Free PMC Article
    2. Identification of mouse CPX-2, a novel member of the metallocarboxypeptidase gene family: cDNA cloning, mRNA distribution, and protein expression and characterization. Xin X, et al. DNA Cell Biol, 1998 Oct. PMID 9809751
    3. Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness. Buniello A, et al. PLoS One, 2013. PMID 23457544, Free PMC Article
    4. Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness. Somma G, et al. J Assoc Res Otolaryngol, 2012 Jun. PMID 22383091, Free PMC Article
    5. Stromal β-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor. Drake KA, et al. Development, 2020 Jul 31. PMID 32541007, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.
      Title: Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables carboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inactive carboxypeptidase-like protein X2
    Names
    carboxypeptidase X 2 (M14 family)
    carboxypeptidase X2
    metallocarboxypeptidase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018867.5 → NP_061355.3  inactive carboxypeptidase-like protein X2 precursor

      See identical proteins and their annotated locations for NP_061355.3

      Status: VALIDATED

      Source sequence(s)
      AC100735, AK019509, BB027417
      Consensus CDS
      CCDS21921.1
      UniProtKB/Swiss-Prot
      O54860, Q8VDQ4, Q9D2L5
      UniProtKB/TrEMBL
      A0A0R4J0C4
      Related
      ENSMUSP00000033149.5, ENSMUST00000033149.5
      Conserved Domains (4) summary
      cd03869
      Location:322 → 647
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      cd11308
      Location:651 → 726
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      smart00231
      Location:146 → 301
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:145 → 300
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      131634416..131756483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508034.5 → XP_006508097.1  inactive carboxypeptidase-like protein X2 isoform X2

      UniProtKB/Swiss-Prot
      O54860, Q8VDQ4, Q9D2L5
      Conserved Domains (3) summary
      cd00057
      Location:145 → 300
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd03869
      Location:326 → 647
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      cl21470
      Location:651 → 681
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

    2. XM_006508033.5 → XP_006508096.1  inactive carboxypeptidase-like protein X2 isoform X1

      UniProtKB/Swiss-Prot
      O54860, Q8VDQ4, Q9D2L5
      Conserved Domains (3) summary
      cd11308
      Location:591 → 666
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cd00057
      Location:145 → 300
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl11393
      Location:326 → 587
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    3. XM_011241864.1 → XP_011240166.1  inactive carboxypeptidase-like protein X2 isoform X3

      Conserved Domains (3) summary
      cd11308
      Location:445 → 520
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cd00057
      Location:13 → 94
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd03869
      Location:120 → 441
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup

    4. XM_030242804.1 → XP_030098664.1  inactive carboxypeptidase-like protein X2 isoform X5

      Conserved Domains (3) summary
      cd11308
      Location:356 → 431
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cd00057
      Location:1 → 65
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl11393
      Location:91 → 352
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    5. XM_006508036.3 → XP_006508099.1  inactive carboxypeptidase-like protein X2 isoform X4

      Conserved Domains (3) summary
      cd11308
      Location:416 → 491
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cd00057
      Location:1 → 65
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd03869
      Location:91 → 412
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2L5.1 GenPept UniProtKB/Swiss-Prot:Q9D2L5

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