G3bp2 G3BP stress granule assembly factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: G3bp2provided by MGI
Official Full Name: G3BP stress granule assembly factor 2provided by MGI
Primary source: MGI:MGI:2442040
See related: Ensembl:ENSMUSG00000029405 AllianceGenome:MGI:2442040
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: G3BP; mKIAA0660; E430034L04Rik
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in positive regulation of stress granule assembly and protein homooligomerization. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be located in cytoplasmic stress granule. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol. Is expressed in several structures, including central nervous system; ovary; sensory organ; and tooth. Orthologous to human G3BP2 (G3BP stress granule assembly factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 38.0), whole brain E14.5 (RPKM 34.0) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E2; 5 45.84 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (92200004..92285584, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (92052145..92137725, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

G3BP2, a stress granule assembly factor, is dispensable for spermatogenesis in mice.
Title: G3BP2, a stress granule assembly factor, is dispensable for spermatogenesis in mice.
Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2.
Title: Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125852 (e-PCR)
- UniSTS:162592

NoName (e-PCR)
- UniSTS:493400

G3bp2 (e-PCR), detects polymorphism
- UniSTS:479101

NoName (e-PCR)
- UniSTS:235217

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress granule assembly	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in stress granule assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras GTPase-activating protein-binding protein 2

Names: GTPase activating protein (SH3 domain) binding protein 2; Ras-GTPase-activating protein (GAP120) SH3-domain binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080794.2 → NP_001074263.1 ras GTPase-activating protein-binding protein 2 isoform a

See identical proteins and their annotated locations for NP_001074263.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).

Source sequence(s)

AK153221, AK169571, BY578810, CN527272

Consensus CDS

CCDS19427.1

UniProtKB/Swiss-Prot

P97379, Q3UL55, Q9R1B8

UniProtKB/TrEMBL

Q3U541, Q3U931

Related

ENSMUSP00000128244.2, ENSMUST00000169094.8

Conserved Domains (2) summary

cd00780
Location:7 → 135

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

cd12464
Location:326 → 408

RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
NM_001080795.2 → NP_001074264.1 ras GTPase-activating protein-binding protein 2 isoform b

See identical proteins and their annotated locations for NP_001074264.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3, 4, and 8 all encode the same isoform (b).

Source sequence(s)

AK076117, AK169571, BY272229, BY578810

Consensus CDS

CCDS39149.1

UniProtKB/TrEMBL

Q3U931, Q542W3

Related

ENSMUSP00000108752.4, ENSMUST00000113127.7

Conserved Domains (2) summary

cd00780
Location:7 → 135

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

cd12464
Location:293 → 375

RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
NM_001080796.2 → NP_001074265.1 ras GTPase-activating protein-binding protein 2 isoform b

See identical proteins and their annotated locations for NP_001074265.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3, 4, and 8 all encode the same isoform (b).

Source sequence(s)

AK151732, AK169571, BY578810, CN527272

Consensus CDS

CCDS39149.1

UniProtKB/TrEMBL

Q3U931, Q542W3

Related

ENSMUSP00000132469.2, ENSMUST00000167918.8

Conserved Domains (2) summary

cd00780
Location:7 → 135

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

cd12464
Location:293 → 375

RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
NM_001080797.2 → NP_001074266.1 ras GTPase-activating protein-binding protein 2 isoform a

See identical proteins and their annotated locations for NP_001074266.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).

Source sequence(s)

AK149427, AK169571, BY578810

Consensus CDS

CCDS19427.1

UniProtKB/Swiss-Prot

P97379, Q3UL55, Q9R1B8

UniProtKB/TrEMBL

Q3U541, Q3U931

Related

ENSMUSP00000128353.2, ENSMUST00000164378.8

Conserved Domains (2) summary

cd00780
Location:7 → 135

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

cd12464
Location:326 → 408

RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
NM_001359195.1 → NP_001346124.1 ras GTPase-activating protein-binding protein 2 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).

Source sequence(s)

AC122438, AC165433

Consensus CDS

CCDS19427.1

UniProtKB/Swiss-Prot

P97379, Q3UL55, Q9R1B8

UniProtKB/TrEMBL

Q3U541, Q3U931

Conserved Domains (2) summary

cd00780
Location:7 → 135

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

cd12464
Location:326 → 408

RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
NM_001359196.1 → NP_001346125.1 ras GTPase-activating protein-binding protein 2 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).

Source sequence(s)

AC122438, AC165433

Consensus CDS

CCDS19427.1

UniProtKB/Swiss-Prot

P97379, Q3UL55, Q9R1B8

UniProtKB/TrEMBL

Q3U541, Q3U931

Conserved Domains (2) summary

cd00780
Location:7 → 135

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

cd12464
Location:326 → 408

RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
NM_001359197.1 → NP_001346126.1 ras GTPase-activating protein-binding protein 2 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3, 4, and 8 all encode the same isoform (b).

Source sequence(s)

AC122438, AC165433

Consensus CDS

CCDS39149.1

UniProtKB/TrEMBL

Q3U931, Q542W3

Conserved Domains (2) summary

cd00780
Location:7 → 135

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

cd12464
Location:293 → 375

RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
NM_011816.4 → NP_035946.2 ras GTPase-activating protein-binding protein 2 isoform a

See identical proteins and their annotated locations for NP_035946.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).

Source sequence(s)

AK145697, AK169571, BY272229, BY578810

Consensus CDS

CCDS19427.1

UniProtKB/Swiss-Prot

P97379, Q3UL55, Q9R1B8

UniProtKB/TrEMBL

Q3U541, Q3U931

Related

ENSMUSP00000144456.2, ENSMUST00000202258.4

Conserved Domains (2) summary

cd00780
Location:7 → 135

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

cd12464
Location:326 → 408

RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

92200004..92285584 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254467.1 → XP_030110327.1 ras GTPase-activating protein-binding protein 2 isoform X1

UniProtKB/TrEMBL

Q3U931, Q542W3

Conserved Domains (2) summary

cd00780
Location:7 → 135

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

cd12464
Location:293 → 375

RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins