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    Cdv3 carnitine deficiency-associated gene expressed in ventricle 3 [ Mus musculus (house mouse) ]

    Gene ID: 321022, updated on 26-Mar-2024

    Summary

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    Official Symbol
    Cdv3provided by MGI
    Official Full Name
    carnitine deficiency-associated gene expressed in ventricle 3provided by MGI
    Primary source
    MGI:MGI:2448759
    See related
    Ensembl:ENSMUSG00000032803 AllianceGenome:MGI:2448759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TPP36; 2510010F10Rik; C230084J24Rik
    Summary
    Located in cytoplasm. Orthologous to human CDV3 (CDV3 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 32.7), CNS E11.5 (RPKM 31.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F1; 9 55.26 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (103230301..103243034, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (103353102..103365835, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25089 Neighboring gene predicted gene, 31701 Neighboring gene inhibitor of carbonic anhydrase Neighboring gene STARR-seq mESC enhancer starr_25090 Neighboring gene topoisomerase (DNA) II binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E573 Neighboring gene STARR-seq mESC enhancer starr_25091 Neighboring gene RIKEN cDNA 5830418P13 gene Neighboring gene STARR-positive B cell enhancer mm9_chr9:103327280-103327581 Neighboring gene STARR-seq mESC enhancer starr_25093 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:103334789-103334972 Neighboring gene STARR-positive B cell enhancer ABC_E5098 Neighboring gene STARR-seq mESC enhancer starr_25094 Neighboring gene STARR-seq mESC enhancer starr_25095 Neighboring gene beaded filament structural protein 2, phakinin Neighboring gene predicted gene 16252 Neighboring gene transmembrane protein 108

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase. Tsuchiya K, et al. FEBS Lett, 2003 Feb 27. PMID 12606058
    2. Novel mRNA molecules are induced in hypertrophied ventricles of carnitine-deficient mice and belong to a family of up-regulated gene in cells overexpressing c-erbB-2. Fukumaru S, et al. Biochim Biophys Acta, 2002 Sep 27. PMID 12359334
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identification and characterization of novel transcripts that may be involved in the development of cardiac hypertrophy caused by carnitine deficiency(carnitine deficiency-associated gene expressed in ventricle (CDV)- 3)
      Title: Novel mRNA molecules are induced in hypertrophied ventricles of carnitine-deficient mice and belong to a family of up-regulated gene in cells overexpressing c-erbB-2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein CDV3
    Names
    carnitine deficiency-associated protein 3
    carnitine deficiency-associated protein CDV3A
    carnitine deficiency-associated protein CDV3B
    tyrosine-phosphorylated protein 36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134426.1 → NP_001127898.1  protein CDV3 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform c).
      Source sequence(s)
      AC122747
      Consensus CDS
      CCDS81064.1
      UniProtKB/TrEMBL
      A0A087WNP6
      Related
      ENSMUSP00000139440.2, ENSMUST00000189896.2
      Conserved Domains (1) summary
      pfam15359
      Location:106 → 224
      CDV3; Carnitine deficiency-associated protein 3

    2. NM_001134427.1 → NP_001127899.1  protein CDV3 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate exon in the 5' region, compared to variant 1, resulting in a protein with a shorter N-terminus (isoform d).
      Source sequence(s)
      AC122747
      Consensus CDS
      CCDS52902.1
      UniProtKB/TrEMBL
      F8WGL9
      Related
      ENSMUSP00000112216.3, ENSMUST00000116517.9
      Conserved Domains (1) summary
      pfam15359
      Location:1 → 97
      CDV3; Carnitine deficiency-associated protein 3

    3. NM_175565.3 → NP_780774.1  protein CDV3 isoform a

      See identical proteins and their annotated locations for NP_780774.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant represents the longest transcript and encodes the longest isoform (a), also known as CDV3A.
      Source sequence(s)
      AC122747, AF215660, AI851067
      Consensus CDS
      CCDS40748.1
      UniProtKB/Swiss-Prot
      Q4VAA2
      Related
      ENSMUSP00000072101.7, ENSMUST00000072249.13
      Conserved Domains (1) summary
      pfam15359
      Location:106 → 224
      CDV3; Carnitine deficiency-associated protein 3

    4. NM_175833.2 → NP_787027.1  protein CDV3 isoform b

      See identical proteins and their annotated locations for NP_787027.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a longer protein (isoform b), also known as CDV3B.
      Source sequence(s)
      AC122747, AI851067, BC052770
      Consensus CDS
      CCDS23454.1
      UniProtKB/Swiss-Prot
      Q4VAA2, Q6P6L7, Q920C7, Q920I4
      Related
      ENSMUSP00000044420.4, ENSMUST00000035484.11
      Conserved Domains (1) summary
      pfam15359
      Location:106 → 224
      CDV3; Carnitine deficiency-associated protein 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      103230301..103243034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511756.1 → XP_006511819.1  protein CDV3 isoform X1

      Conserved Domains (1) summary
      pfam15359
      Location:106 → 224
      CDV3; Carnitine deficiency-associated protein 3

    2. XM_006511758.5 → XP_006511821.1  protein CDV3 isoform X2

      UniProtKB/TrEMBL
      A0A087WS49
      Related
      ENSMUSP00000140900.2, ENSMUST00000190226.7
      Conserved Domains (1) summary
      pfam15359
      Location:1 → 97
      CDV3; Carnitine deficiency-associated protein 3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4VAA2.2 GenPept UniProtKB/Swiss-Prot:Q4VAA2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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