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    Ube2v1 ubiquitin-conjugating enzyme E2 variant 1 [ Mus musculus (house mouse) ]

    Gene ID: 66589, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ube2v1provided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2 variant 1provided by MGI
    Primary source
    MGI:MGI:1913839
    See related
    Ensembl:ENSMUSG00000078923 AllianceGenome:MGI:1913839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CROC1; UEV-1; CROC-1; D7Bwg1382e; 0610011J09Rik
    Summary
    Enables ubiquitin conjugating enzyme binding activity. Contributes to ubiquitin conjugating enzyme activity. Acts upstream of or within error-free postreplication DNA repair. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of UBC13-UEV1A complex and ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to several human genes including PEDS1-UBE2V1 (PEDS1-UBE2V1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in stomach adult (RPKM 69.4), frontal lobe adult (RPKM 57.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H3; 2 87.44 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (167449559..167473933, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (167607639..167632020, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 11476 Neighboring gene predicted gene, 31619 Neighboring gene STARR-positive B cell enhancer ABC_E4523 Neighboring gene STARR-seq mESC enhancer starr_06439 Neighboring gene ribosomal protein L18 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10162 Neighboring gene STARR-positive B cell enhancer ABC_E820 Neighboring gene STARR-positive B cell enhancer ABC_E3420 Neighboring gene predicted gene, 31852 Neighboring gene STARR-positive B cell enhancer ABC_E11175 Neighboring gene STARR-positive B cell enhancer ABC_E7889 Neighboring gene plasmanylethanolamine desaturase 1 Neighboring gene STARR-positive B cell enhancer ABC_E2657

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Recurrent carcinoma of the rectum, surgical treatment. JACKSON BR, et al. Calif Med, 1959 Sep. PMID 14406273, Free PMC Article
    2. Molecular cloning and functional characterization of two murine cDNAs which encode Ubc variants involved in DNA repair and mutagenesis. Franko J, et al. Biochim Biophys Acta, 2001 May 28. PMID 11406273
    3. The tomato Fni3 lysine-63-specific ubiquitin-conjugating enzyme and suv ubiquitin E2 variant positively regulate plant immunity. Mural RV, et al. Plant Cell, 2013 Sep. PMID 24076975, Free PMC Article
    4. Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme. Petroski MD, et al. J Biol Chem, 2007 Oct 12. PMID 17709375
    5. Roles of mouse UBC13 in DNA postreplication repair and Lys63-linked ubiquitination. Ashley C, et al. Gene, 2002 Feb 20. PMID 12039045

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF/NF-kappaB-regulated apoptosis and the p53/PCNA- and ATM/ATR-Chk1/2-controlled DNA-damage response pathways.
      Title: Simulated Microgravity Promotes Cell Apoptosis Through Suppressing Uev1A/TICAM/TRAF/NF-κB-Regulated Anti-Apoptosis and p53/PCNA- and ATM/ATR-Chk1/2-Controlled DNA-Damage Response Pathways.
    2. modification of proteins with Lys(63)-linked ubiquitin chains occurs through a UEV1A-independent substrate modification and UEV1A-dependent Lys(63)-linked ubiquitin chain synthesis mechanism
      Title: Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ubiquitin conjugating enzyme activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within error-free postreplication DNA repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of UBC13-UEV1A complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of ubiquitin conjugating enzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 variant 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311131.1 → NP_001298060.1  ubiquitin-conjugating enzyme E2 variant 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK158230, CF171728
      Consensus CDS
      CCDS79868.1
      UniProtKB/TrEMBL
      B7ZBY7
      Related
      ENSMUSP00000114764.2, ENSMUST00000151365.8
      Conserved Domains (1) summary
      smart00212
      Location:42 → 168
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    2. NM_001311146.1 → NP_001298075.1  ubiquitin-conjugating enzyme E2 variant 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon in the 5' coding region and lacks an exon in the 3' coding region compred to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL589870
      Consensus CDS
      CCDS79869.1
      UniProtKB/Swiss-Prot
      Q9CZY3
      Related
      ENSMUSP00000053109.7, ENSMUST00000060645.13
      Conserved Domains (1) summary
      cl00154
      Location:16 → 100
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_023230.2 → NP_075719.1  ubiquitin-conjugating enzyme E2 variant 1 isoform 2

      See identical proteins and their annotated locations for NP_075719.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon which results in the use of an alternate start codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK158230
      Consensus CDS
      CCDS17103.1
      UniProtKB/Swiss-Prot
      A2A467, Q8VEB5, Q9CZY3, Q9ERI7
      UniProtKB/TrEMBL
      Q569Y6
      Related
      ENSMUSP00000104830.4, ENSMUST00000109207.10
      Conserved Domains (1) summary
      smart00212
      Location:16 → 142
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      167449559..167473933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500014.5 → XP_006500077.1  ubiquitin-conjugating enzyme E2 variant 1 isoform X1

      Conserved Domains (1) summary
      cl00154
      Location:42 → 126
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZY3.1 GenPept UniProtKB/Swiss-Prot:Q9CZY3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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