Crisp1 cysteine-rich secretory protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crisp1provided by MGI
Official Full Name: cysteine-rich secretory protein 1provided by MGI
Primary source: MGI:MGI:102553
See related: Ensembl:ENSMUSG00000025431 AllianceGenome:MGI:102553
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aeg1; SCP 1; CRISP-1
Summary: Predicted to be located in extracellular region and specific granule. Predicted to be active in extracellular space. Orthologous to human CRISP3 (cysteine rich secretory protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward genital fat pad adult (RPKM 864.1) See more
Orthologs: human all
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Genomic context

Location:: 17 B2; 17 19.47 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (40604649..40630098, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (40293758..40319207, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results demonstrated that the sustained level of AEG-1 as an important anti-apoptotic factor in nigral dopaminergic (DA) neurons might potentiate the therapeutic effects of treatments, such as Rheb(S16H) administration, on the degeneration of the DA pathway that characterizes Parkinson's disease.
Title: Upregulation of neuronal astrocyte elevated gene-1 protects nigral dopaminergic neurons in vivo.
These observations reveal that CRISP proteins are relevant for epididymal epithelium differentiation and male fertility, contributing to a better understanding of the fine-tuning mechanisms underlying sperm maturation and immunotolerance in the epididymis with clear implications for human epididymal physiology and pathology.
Title: Impaired male fertility and abnormal epididymal epithelium differentiation in mice lacking CRISP1 and CRISP4.
phenotype of CRISP1 null males is modulated by the genetic context and reveal new roles for the protein in both the functional events and signaling pathways associated to sperm capacitation.
Title: Influence of the genetic background on the reproductive phenotype of mice lacking Cysteine-Rich Secretory Protein 1 (CRISP1).
patch clamping of sperm revealed that CRISP1 has the ability to regulate CatSper, the principal sperm Ca(2+) channel involved in hyperactivation and essential for fertility
Title: CRISP1 as a novel CatSper regulator that modulates sperm motility and orientation during fertilization.
These results suggest that CRISP1 may be an important structural component of mouse hair and that its strain-specific dysregulation may indicate a predisposition to hair shaft disease such as Alopecia areata
Title: Crisp1 and alopecia areata in C3H/HeJ mice.
the feasibility of generating an immune response to mCRISP1 protein by DNA vaccine and pcDNA-mCRISP1 plasmid causing significant anti-fertility potential.
Title: Immunogenicity study of plasmid DNA encoding mouse cysteine-rich secretory protein-1 (mCRISP1) as a contraceptive vaccine.
These results indicate that CRISP proteins are players in the mammalian fertilization process.
Title: Impaired sperm fertilizing ability in mice lacking Cysteine-RIch Secretory Protein 1 (CRISP1).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:490592

8T (e-PCR), detects polymorphism
- UniSTS:140988

AW324342 (e-PCR)
- UniSTS:186101

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in specific granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cysteine-rich secretory protein 1

Names: acidic epididymal glycoprotein 1; sperm-coating glycoprotein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009638.3 → NP_033768.3 cysteine-rich secretory protein 1 precursor

See identical proteins and their annotated locations for NP_033768.3

Status: VALIDATED

Source sequence(s)

AC154497, AK009449, M92849

Consensus CDS

CCDS28784.1

UniProtKB/Swiss-Prot

Q03401

UniProtKB/TrEMBL

Q545H0, Q91XA3

Related

ENSMUSP00000026498.5, ENSMUST00000026498.5

Conserved Domains (2) summary

cd05383
Location:37 → 172

SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...

pfam08562
Location:190 → 244

Crisp; Crisp