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    Gtpbp2 GTP binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 56055, updated on 12-May-2024

    Summary

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    Official Symbol
    Gtpbp2provided by MGI
    Official Full Name
    GTP binding protein 2provided by MGI
    Primary source
    MGI:MGI:1860138
    See related
    Ensembl:ENSMUSG00000023952 AllianceGenome:MGI:1860138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    nmf205
    Summary
    Predicted to enable GTP binding activity; identical protein binding activity; and translation elongation factor activity. Acts upstream of or within nuclear-transcribed mRNA catabolic process, no-go decay and rescue of stalled ribosome. Is expressed in central nervous system and eye. Orthologous to human GTPBP2 (GTP binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 32.2), thymus adult (RPKM 27.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 C; 17 22.89 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46470153..46480294)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46159227..46169370)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S18A Neighboring gene radial spoke head 9 homolog (Chlamydomonas) Neighboring gene MAD2L1 binding protein Neighboring gene STARR-positive B cell enhancer ABC_E5614 Neighboring gene STARR-positive B cell enhancer ABC_E5615 Neighboring gene polymerase (DNA directed), eta (RAD 30 related) Neighboring gene exportin 5 Neighboring gene microRNA 693

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation. Ishimura R, et al. Elife, 2016 Apr 16. PMID 27085088, Free PMC Article
    2. Cloning, expression analysis, and chromosomal mapping of GTPBP2, a novel member of the G protein family. Watanabe M, et al. Gene, 2000 Oct 3. PMID 11054535
    3. GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis. Terrey M, et al. Elife, 2020 Nov 13. PMID 33186095, Free PMC Article
    4. RNA function. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration. Ishimura R, et al. Science, 2014 Jul 25. PMID 25061210, Free PMC Article
    5. Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase. Kudo H, et al. Biochem Biophys Res Commun, 2000 Jun 7. PMID 10833435

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-aminoacyl-tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, no-go decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within rescue of stalled ribosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GTP-binding protein 2
    Names
    GTP-binding-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145979.2 → NP_001139451.1  GTP-binding protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001139451.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC116739
      UniProtKB/Swiss-Prot
      Q3UJK4
      Conserved Domains (1) summary
      COG5258
      Location:1 → 500
      GTPBP1; GTPase [General function prediction only]

    2. NM_001357745.2 → NP_001344674.1  GTP-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116739
      Conserved Domains (1) summary
      COG5258
      Location:1 → 500
      GTPBP1; GTPase [General function prediction only]

    3. NM_001410154.1 → NP_001397083.1  GTP-binding protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC116739
      UniProtKB/Swiss-Prot
      Q3UJK4, Q9EST7, Q9JIX7

    4. NM_001410155.1 → NP_001397084.1  GTP-binding protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116739

    5. NM_001410156.1 → NP_001397085.1  GTP-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116739
      Conserved Domains (1) summary
      COG5258
      Location:1 → 500
      GTPBP1; GTPase [General function prediction only]

    6. NM_001410157.1 → NP_001397086.1  GTP-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116739
      Conserved Domains (1) summary
      COG5258
      Location:1 → 500
      GTPBP1; GTPase [General function prediction only]

    7. NM_001410158.1 → NP_001397087.1  GTP-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116739
      Conserved Domains (1) summary
      COG5258
      Location:1 → 500
      GTPBP1; GTPase [General function prediction only]

    8. NM_001410159.1 → NP_001397088.1  GTP-binding protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116739

    9. NM_001410160.1 → NP_001397089.1  GTP-binding protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116739

    10. NM_019581.4 → NP_062527.2  GTP-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_062527.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC116739
      Consensus CDS
      CCDS50122.1
      UniProtKB/Swiss-Prot
      Q3UJK4, Q9EST7, Q9JIX7
      UniProtKB/TrEMBL
      E9QA45
      Related
      ENSMUSP00000024748.8, ENSMUST00000024748.14
      Conserved Domains (1) summary
      cl27768
      Location:59 → 588
      SelB; Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]

    RNA

    1. NR_176957.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116739

    2. NR_176958.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116739

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46470153..46480294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524651.5 → XP_006524714.1  GTP-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      E9QA45
      Conserved Domains (1) summary
      COG5258
      Location:28 → 561
      GTPBP1; GTPase [General function prediction only]

    2. XM_036160688.1 → XP_036016581.1  GTP-binding protein 2 isoform X2

      Conserved Domains (1) summary
      COG5258
      Location:1 → 500
      GTPBP1; GTPase [General function prediction only]

    RNA

    1. XR_004939561.1 RNA Sequence

      Related
      ENSMUST00000169383.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UJK4.1 GenPept UniProtKB/Swiss-Prot:Q3UJK4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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