Mri1 methylthioribose-1-phosphate isomerase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mri1provided by MGI
Official Full Name: methylthioribose-1-phosphate isomerase 1provided by MGI
Primary source: MGI:MGI:1915123
See related: Ensembl:ENSMUSG00000004996 AllianceGenome:MGI:1915123
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2410018C20Rik
Summary: Predicted to enable S-methyl-5-thioribose-1-phosphate isomerase activity and identical protein binding activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to act upstream of or within methionine biosynthetic process. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Orthologous to human MRI1 (methylthioribose-1-phosphate isomerase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 43.2), adrenal adult (RPKM 35.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C2; 8 40.74 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (84977205..84983953, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (84250576..84257324, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mri1 (e-PCR), detects polymorphism
- UniSTS:546871

RH126162 (e-PCR)
- UniSTS:162873

RH118315 (e-PCR)
- UniSTS:160956

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables S-methyl-5-thioribose-1-phosphate isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-methionine salvage from methylthioadenosine	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cellular biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cellular metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methionine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: methylthioribose-1-phosphate isomerase

Names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase; methylthioribose-1-phosphate isomerase homolog; translation initiation factor eIF-2B subunit alpha/beta/delta-like protein

NP_080699.3

EC 5.3.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026423.4 → NP_080699.3 methylthioribose-1-phosphate isomerase

See identical proteins and their annotated locations for NP_080699.3

Status: VALIDATED

Source sequence(s)

AK013882, AK047287

Consensus CDS

CCDS22473.1

UniProtKB/Swiss-Prot

Q8BXF6, Q9CQT1

Related

ENSMUSP00000122623.2, ENSMUST00000126435.8

Conserved Domains (2) summary

TIGR00512
Location:4 → 346

salvage_mtnA; S-methyl-5-thioribose-1-phosphate isomerase

pfam01008
Location:44 → 346

IF-2B; Initiation factor 2 subunit family