Lrg1 leucine-rich alpha-2-glycoprotein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrg1provided by MGI
Official Full Name: leucine-rich alpha-2-glycoprotein 1provided by MGI
Primary source: MGI:MGI:1924155
See related: Ensembl:ENSMUSG00000037095 AllianceGenome:MGI:1924155
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lrg; Lrhg; 1300008B03Rik; 2310031E04Rik
Summary: Enables transforming growth factor beta receptor binding activity. Acts upstream of or within several processes, including brown fat cell differentiation; positive regulation of endothelial cell proliferation; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in extracellular space. Is expressed in pancreas mesenchyme. Orthologous to human LRG1 (leucine rich alpha-2-glycoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 229.9), mammary gland adult (RPKM 136.7) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 29.17 cM; 17 D

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (56426678..56428946, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (56119678..56121946, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFbeta1- Smad1/5 signaling pathway.
Title: Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
Exosome enriched leucine-rich alpha-2-glycoprotein-1 and extracellular matrix protein 1 proteins induce abnormal placental angiogenesis in pregnant mice.
Title: Exosome enriched leucine-rich alpha-2-glycoprotein-1 and extracellular matrix protein 1 proteins induce abnormal placental angiogenesis in pregnant mice.
Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia-reperfusion injury by modulating various cells.
Title: Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells.
Crystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation.
Title: Crystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation.
LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation.
Title: LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation.
LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency.
Title: LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency.
Leucine rich alpha-2-glycoprotein 1 (Lrg1) silencing protects against sepsis-mediated brain injury by inhibiting transforming growth factor beta1 (TGFbeta1)/SMAD signaling pathway.
Title: Leucine rich alpha-2-glycoprotein 1 (Lrg1) silencing protects against sepsis-mediated brain injury by inhibiting transforming growth factor beta1 (TGFβ1)/SMAD signaling pathway.
LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance.
Title: LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance.
LRG1 facilitates corneal fibrotic response by inducing neutrophil chemotaxis via Stat3 signaling in alkali-burned mouse corneas.
Title: LRG1 facilitates corneal fibrotic response by inducing neutrophil chemotaxis via Stat3 signaling in alkali-burned mouse corneas.
The Skin-Liver Axis Modulates the Psoriasiform Phenotype and Involves Leucine-Rich alpha-2 Glycoprotein.
Title: The Skin-Liver Axis Modulates the Psoriasiform Phenotype and Involves Leucine-Rich α-2 Glycoprotein.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (5)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables potassium channel activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transforming growth factor beta receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables type I transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
enables type II transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of keratinocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of keratinocyte migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of leukocyte adhesion to vascular endothelial cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of leukocyte adhesion to vascular endothelial cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of epithelial cell proliferation involved in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of epithelial cell proliferation involved in wound healing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within wound healing, spreading of epidermal cells	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within wound healing, spreading of epidermal cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leucine-rich alpha-2-glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029796.2 → NP_084072.1 leucine-rich alpha-2-glycoprotein precursor

See identical proteins and their annotated locations for NP_084072.1

Status: PROVISIONAL

Source sequence(s)

BC030733

Consensus CDS

CCDS28895.1

UniProtKB/TrEMBL

Q91XL1

Related

ENSMUSP00000038048.8, ENSMUST00000041357.9

Conserved Domains (4) summary

smart00082
Location:292 → 338

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:74 → 294

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:65 → 86

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:109 → 169

LRR_8; Leucine rich repeat