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    Npepps aminopeptidase puromycin sensitive [ Mus musculus (house mouse) ]

    Gene ID: 19155, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Npeppsprovided by MGI
    Official Full Name
    aminopeptidase puromycin sensitiveprovided by MGI
    Primary source
    MGI:MGI:1101358
    See related
    Ensembl:ENSMUSG00000001441 AllianceGenome:MGI:1101358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Psa; goku; AAP-S; MP100
    Summary
    Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in cellular response to hypoxia; peptide catabolic process; and proteolysis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and integumental system. Orthologous to human NPEPPS (aminopeptidase puromycin sensitive). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 20.8), CNS E14 (RPKM 19.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 60.95 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97096668..97171503, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97205842..97280660, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8447 Neighboring gene TBK1 binding protein 1 Neighboring gene microRNA 7235 Neighboring gene karyopherin subunit beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E1842 Neighboring gene STARR-positive B cell enhancer ABC_E910 Neighboring gene predicted gene 11592 Neighboring gene STARR-seq mESC enhancer starr_30592 Neighboring gene STARR-seq mESC enhancer starr_30593 Neighboring gene predicted gene, 31005 Neighboring gene STARR-seq mESC enhancer starr_30594 Neighboring gene mitochondrial ribosomal protein L45

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections. Towne CF, et al. J Immunol, 2008 Feb 1. PMID 18209067
    2. Male reproductive defects caused by puromycin-sensitive aminopeptidase deficiency in mice. Osada T, et al. Mol Endocrinol, 2001 Jun. PMID 11376114
    3. Puromycin-sensitive aminopeptidase is essential for the maternal recognition of pregnancy in mice. Osada T, et al. Mol Endocrinol, 2001 Jun. PMID 11376108
    4. Increased anxiety and impaired pain response in puromycin-sensitive aminopeptidase gene-deficient mice obtained by a mouse gene-trap method. Osada T, et al. J Neurosci, 1999 Jul 15. PMID 10407043, Free PMC Article
    5. PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway. Huang B, et al. J Mol Cell Biol, 2021 Oct 21. PMID 34048566, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway.
      Title: PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway.
    2. Nucleocytoplasmic transfer of cyclin dependent kinase 5 and its binding to puromycin-sensitive aminopeptidase in Dictyostelium discoideum
      Title: Nucleocytoplasmic transfer of cyclin dependent kinase 5 and its binding to puromycin-sensitive aminopeptidase in Dictyostelium discoideum.
    3. findings show that by promoting autophagic protein clearance, PSA helps protect against accumulation of aggregation-prone proteins and proteotoxicity
      Title: Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy.
    4. These data indicate that PSA may play a role in limiting MHC class I Ag presentation in dendritic cells in vivo but that it is not essential for generating most MHC class I-presented peptides or for stimulating CTL responses to several Ags.
      Title: Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102199

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    puromycin-sensitive aminopeptidase
    Names
    cytosol alanyl aminopeptidase
    NP_032968.2
    XP_011247104.1
    XP_030101528.1
    XP_030101529.1
    XP_030101530.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008942.3 → NP_032968.2  puromycin-sensitive aminopeptidase

      See identical proteins and their annotated locations for NP_032968.2

      Status: VALIDATED

      Source sequence(s)
      AI839456, BC098212
      Consensus CDS
      CCDS25317.1
      UniProtKB/Swiss-Prot
      Q11011, Q3UZE0, Q5PR74, Q91VJ8
      UniProtKB/TrEMBL
      F6QYF8
      Related
      ENSMUSP00000001480.8, ENSMUST00000001480.14
      Conserved Domains (3) summary
      cd09601
      Location:62 → 505
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:54 → 442
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:580 → 891
      ERAP1_C; ERAP1-like C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      97096668..97171503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245670.1 → XP_030101530.1  puromycin-sensitive aminopeptidase isoform X2

      Conserved Domains (3) summary
      TIGR02414
      Location:1 → 128
      pepN_proteo; aminopeptidase N, Escherichia coli type
      pfam01433
      Location:1 → 51
      Peptidase_M1; Peptidase family M1 domain
      pfam11838
      Location:132 → 445
      ERAP1_C; ERAP1-like C-terminal domain

    2. XM_030245668.2 → XP_030101528.1  puromycin-sensitive aminopeptidase isoform X1

      UniProtKB/TrEMBL
      F6QYF8
      Conserved Domains (2) summary
      cd09601
      Location:1 → 344
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:423 → 736
      ERAP1_C; ERAP1-like C-terminal domain

    3. XM_011248802.2 → XP_011247104.1  puromycin-sensitive aminopeptidase isoform X1

      See identical proteins and their annotated locations for XP_011247104.1

      UniProtKB/TrEMBL
      F6QYF8
      Conserved Domains (2) summary
      cd09601
      Location:1 → 344
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:423 → 736
      ERAP1_C; ERAP1-like C-terminal domain

    4. XM_030245669.2 → XP_030101529.1  puromycin-sensitive aminopeptidase isoform X1

      UniProtKB/TrEMBL
      F6QYF8
      Conserved Domains (2) summary
      cd09601
      Location:1 → 344
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:423 → 736
      ERAP1_C; ERAP1-like C-terminal domain

    RNA

    1. XR_879535.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q11011.2 GenPept UniProtKB/Swiss-Prot:Q11011

    Gene LinkOut

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