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    Slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 57738, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Slc15a2provided by MGI
    Official Full Name
    solute carrier family 15 (H+/peptide transporter), member 2provided by MGI
    Primary source
    MGI:MGI:1890457
    See related
    Ensembl:ENSMUSG00000022899 AllianceGenome:MGI:1890457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pept2; 8430408C16Rik
    Summary
    Enables dipeptide transmembrane transporter activity and high-affinity oligopeptide transmembrane transporter activity. Involved in several processes, including dipeptide import across plasma membrane; peptidoglycan transport; and regulation of nucleotide-binding activity oligomerization domain containing signaling pathway. Acts upstream of or within oligopeptide transport. Located in membrane. Is integral component of plasma membrane. Is expressed in several structures, including genitourinary system; integumental system; nervous system; nose; and respiratory system. Orthologous to human SLC15A2 (solute carrier family 15 member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney adult (RPKM 7.8), frontal lobe adult (RPKM 3.5) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc15a2 in Genome Data Viewer
    Location:
    16 B3; 16 25.97 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (36570523..36605506, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36750161..36785158, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40772 Neighboring gene STARR-positive B cell enhancer mm9_chr16:36711953-36712254 Neighboring gene immunoglobulin-like domain containing receptor 1 Neighboring gene STARR-seq mESC enhancer starr_40773 Neighboring gene RNA guanylyltransferase and 5'-phosphatase pseudogene Neighboring gene STARR-seq mESC enhancer starr_40774 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E764 Neighboring gene ELL associated factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E1185 Neighboring gene STARR-positive B cell enhancer ABC_E10903 Neighboring gene IQ calmodulin-binding motif containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E5541 Neighboring gene STARR-positive B cell enhancer ABC_E99 Neighboring gene RIKEN cDNA 4930565N06 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:36884785-36885086 Neighboring gene golgin B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Importance of Peptide transporter 2 on the cerebrospinal fluid efflux kinetics of glycylsarcosine characterized by nonlinear mixed effects modeling. Huh Y, et al. Pharm Res, 2013 May. PMID 23371515, Free PMC Article
    2. Mouse endogenous retroviruses can trigger premature transcriptional termination at a distance. Li J, et al. Genome Res, 2012 May. PMID 22367191, Free PMC Article
    3. Kyotorphin transport and metabolism in rat and mouse neonatal astrocytes. Xiang J, et al. Brain Res, 2010 Aug 6. PMID 20537989, Free PMC Article
    4. Enhanced antinociceptive response to intracerebroventricular kyotorphin in Pept2 null mice. Jiang H, et al. J Neurochem, 2009 Jun. PMID 19383084, Free PMC Article
    5. Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice. Kamal MA, et al. Am J Physiol Regul Integr Comp Physiol, 2009 Apr. PMID 19225147, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study shows that SLC15A2 mediates the transport of bacterially derived di/tripeptides to enhance the nucleotide-binding oligomerization domain-dependent immune response in mouse bone marrow-derived macrophages
      Title: SLC15A2 and SLC15A4 Mediate the Transport of Bacterially Derived Di/Tripeptides To Enhance the Nucleotide-Binding Oligomerization Domain-Dependent Immune Response in Mouse Bone Marrow-Derived Macrophages.
    2. We found marked changes in protein expression and functional activity of PhT1 and PepT2, the former predominating in adult and the latter in neonate
      Title: Divergent developmental expression and function of the proton-coupled oligopeptide transporters PepT2 and PhT1 in regional brain slices of mouse and rat.
    3. JAK3 is a powerful regulator of the peptide transporters PEPT1 and PEPT2.
      Title: Effect of Janus kinase 3 on the peptide transporters PEPT1 and PEPT2.
    4. The study presents a pharmacokinetic model to quantitate the distribution kinetics of glycylsarcosine, a substrate of PepT2, in blood, cerebrospinal fluid and kidney in wild-type and PepT2 knockout mice.
      Title: Importance of Peptide transporter 2 on the cerebrospinal fluid efflux kinetics of glycylsarcosine characterized by nonlinear mixed effects modeling.
    5. Report influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice.
      Title: Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice.
    6. PEPT2 to be the dominant transporter for the reabsorption of di- and tripeptides and its pharmacological substrates in the organism, and for the removal of these substrates from the cerebrospinal fluid
      Title: Peptide transporters and their roles in physiological processes and drug disposition.
    7. Astrocytes from neonatal PEPT2-/- mice had reduced ALA and carnosine uptake compared to PEPT2+/+ mice. Results demonstrate that PEPT2 is the primary transporter responsible for the astrocytic uptake of ALA and carnosine.
      Title: PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes.
    8. PEPT2 is the main system responsible for tubular reabsorption of peptide-bound amino acids, although this does not lead to major changes in renal excretion of protein or free amino acids.
      Title: Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney.
    9. PEPT2 is responsible for dipeptide uptake in choroid plexus tissue
      Title: Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus.
    10. Peptide transport in the mammary gland
      Title: Peptide transport in the mammary gland: expression and distribution of PEPT2 mRNA and protein.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dipeptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptide transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables dipeptide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables high-affinity oligopeptide transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tripeptide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibacterial innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dipeptide import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dipeptide import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dipeptide import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dipeptide transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dipeptide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oligopeptide transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidoglycan transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in renal absorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tripeptide import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in phagocytic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 15 member 2
    Names
    kidney H(+)/peptide cotransporter
    peptide transporter 2
    proton-dependent high affinity oligopeptide transporter PepT2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145899.2 → NP_001139371.2  solute carrier family 15 member 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate segment at the 3' end compared to variant 1, which results in a frameshift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC117662, AEKQ02018542
      Consensus CDS
      CCDS49842.1
      UniProtKB/TrEMBL
      E9Q329, Q80XC0, Q9CXC0
      Related
      ENSMUSP00000132029.3, ENSMUST00000164579.9
      Conserved Domains (1) summary
      cl28910
      Location:54 → 243
      MFS; Major Facilitator Superfamily

    2. NM_021301.4 → NP_067276.3  solute carrier family 15 member 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC117662, AEKQ02018542
      Consensus CDS
      CCDS28156.1
      UniProtKB/Swiss-Prot
      Q9ES07
      UniProtKB/TrEMBL
      E9QMN8, Q9JM03
      Related
      ENSMUSP00000023616.4, ENSMUST00000023616.11
      Conserved Domains (1) summary
      TIGR00926
      Location:69 → 707
      2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      36570523..36605506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522430.4 → XP_006522493.1  solute carrier family 15 member 2 isoform X1

      See identical proteins and their annotated locations for XP_006522493.1

      Conserved Domains (1) summary
      TIGR00926
      Location:2 → 403
      2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)

    RNA

    1. XR_003951808.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ES07.1 GenPept UniProtKB/Swiss-Prot:Q9ES07

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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