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    Gfi1 growth factor independent 1 transcription repressor [ Mus musculus (house mouse) ]

    Gene ID: 14581, updated on 27-Jul-2021

    Summary

    Official Symbol
    Gfi1provided by MGI
    Official Full Name
    growth factor independent 1 transcription repressorprovided by MGI
    Primary source
    MGI:MGI:103170
    See related
    Ensembl:ENSMUSG00000029275
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; Pa; Gfi-; Pal1; Gfi-1; Pal-1; AW495828
    Expression
    Biased expression in thymus adult (RPKM 40.7), colon adult (RPKM 6.0) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gfi1 in Genome Data Viewer
    Location:
    5 F; 5 52.23 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107864521..107873671, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107716655..107725805, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (108145674..108153363, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Gfi1 +35 kb enhancer Neighboring gene RIKEN cDNA 4930428O21 gene Neighboring gene +19.5 kb enhancer downstream of Gfi1 Neighboring gene Gfi1 +5.8 kb enhancer Neighboring gene Gfi1 promoter regions Neighboring gene -8.7 kb enhancer upstream of Gfi1 Neighboring gene predicted gene, 42147

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inner ear auditory receptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of calcidiol 1-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-6-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of histone H3-K4 methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger protein Gfi-1
    Names
    growth factor independent protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267621.1NP_001254550.1  zinc finger protein Gfi-1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate 5' exon and thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a distinct and longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AC138666, AV261275
      Consensus CDS
      CCDS59680.1
      UniProtKB/TrEMBL
      H3BJM0
      Related
      ENSMUSP00000135039.3, ENSMUST00000065478.12
      Conserved Domains (3) summary
      COG5048
      Location:321483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:381401
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:421446
      zf-H2C2_2; Zinc-finger double domain
    2. NM_010278.2NP_034408.1  zinc finger protein Gfi-1 isoform 1

      See identical proteins and their annotated locations for NP_034408.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AC138666, AV261275
      Consensus CDS
      CCDS57371.1
      UniProtKB/Swiss-Prot
      P70338
      UniProtKB/TrEMBL
      A0A0R4J292
      Related
      ENSMUSP00000135884.3, ENSMUST00000031205.16
      Conserved Domains (3) summary
      COG5048
      Location:255417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:315335
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:355380
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      107864521..107873671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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