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    Inpp1 inositol polyphosphate-1-phosphatase [ Mus musculus (house mouse) ]

    Gene ID: 16329, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Inpp1provided by MGI
    Official Full Name
    inositol polyphosphate-1-phosphataseprovided by MGI
    Primary source
    MGI:MGI:104848
    See related
    Ensembl:ENSMUSG00000026102 AllianceGenome:MGI:104848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2300002C06Rik
    Summary
    Predicted to enable inositol-1,4-bisphosphate 1-phosphatase activity. Predicted to be involved in inositol phosphate dephosphorylation. Is expressed in several structures, including nervous system; sensory organ; and skeleton. Orthologous to human INPP1 (inositol polyphosphate-1-phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 6.4), CNS E18 (RPKM 4.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C1.1; 1 26.99 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52824584..52856847, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52785425..52817688, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5753 Neighboring gene nuclear envelope integral membrane protein 2 Neighboring gene major facilitator superfamily domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_00904 Neighboring gene STARR-positive B cell enhancer ABC_E3274 Neighboring gene STARR-positive B cell enhancer ABC_E1543 Neighboring gene STARR-positive B cell enhancer ABC_E3275 Neighboring gene 3-hydroxyisobutyryl-Coenzyme A hydrolase Neighboring gene STARR-seq mESC enhancer starr_00905 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene RIKEN cDNA 1700019D03 gene Neighboring gene STARR-seq mESC enhancer starr_00906 Neighboring gene STARR-seq mESC enhancer starr_00907

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor. Woodcock EA, et al. J Biol Chem, 2002 Jun 21. PMID 11932254
    2. The role of phosphatases in inositol signaling reactions. Majerus PW, et al. J Biol Chem, 1999 Apr 16. PMID 10196133
    3. Identification and chromosomal mapping of the mouse inositol polyphosphate 1-phosphatase gene. Okabe I, et al. Genomics, 1995 Nov 20. PMID 8586440
    4. Synaptic defects and compensatory regulation of inositol metabolism in inositol polyphosphate 1-phosphatase mutants. Acharya JK, et al. Neuron, 1998 Jun. PMID 9655509
    5. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Varfolomeev EE, et al. Immunity, 1998 Aug. PMID 9729047

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor.
      Title: Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-1,4-bisphosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inositol polyphosphate 1-phosphatase
    Names
    IPP
    IPPase
    NP_032410.2
    XP_011236743.1
    XP_011236744.1
    XP_036018134.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008384.2 → NP_032410.2  inositol polyphosphate 1-phosphatase

      See identical proteins and their annotated locations for NP_032410.2

      Status: VALIDATED

      Source sequence(s)
      AK078382, BY700907, BY713450
      Consensus CDS
      CCDS14947.1
      UniProtKB/Swiss-Prot
      P49442, Q8R3L1
      Related
      ENSMUSP00000027271.3, ENSMUST00000027271.9
      Conserved Domains (1) summary
      cd01640
      Location:4 → 384
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      52824584..52856847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162241.1 → XP_036018134.1  inositol polyphosphate 1-phosphatase isoform X1

      UniProtKB/Swiss-Prot
      P49442, Q8R3L1
      Conserved Domains (1) summary
      cd01640
      Location:4 → 384
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    2. XM_011238441.3 → XP_011236743.1  inositol polyphosphate 1-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_011236743.1

      UniProtKB/Swiss-Prot
      P49442, Q8R3L1
      Conserved Domains (1) summary
      cd01640
      Location:4 → 384
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    3. XM_011238442.4 → XP_011236744.1  inositol polyphosphate 1-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_011236744.1

      UniProtKB/Swiss-Prot
      P49442, Q8R3L1
      Conserved Domains (1) summary
      cd01640
      Location:4 → 384
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49442.2 GenPept UniProtKB/Swiss-Prot:P49442

    Gene LinkOut

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