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    Tiam1 T cell lymphoma invasion and metastasis 1 [ Mus musculus (house mouse) ]

    Gene ID: 21844, updated on 19-Jul-2021

    Summary

    Official Symbol
    Tiam1provided by MGI
    Official Full Name
    T cell lymphoma invasion and metastasis 1provided by MGI
    Primary source
    MGI:MGI:103306
    See related
    Ensembl:ENSMUSG00000002489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D16Ium1; AI847750; D16Ium10; D16Ium10e
    Expression
    Broad expression in cerebellum adult (RPKM 9.6), frontal lobe adult (RPKM 5.9) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tiam1 in Genome Data Viewer
    Location:
    16 C3.3; 16 51.5 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (89583999..89942488, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (89787111..90145600, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (89787356..89974944, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene cyclin G1 pseudogene Neighboring gene predicted gene, 35500 Neighboring gene predicted gene, 52239 Neighboring gene predicted gene 2805 Neighboring gene predicted gene 10789 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene predicted gene, 35714

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in activation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in brain-derived neurotrophic factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of non-canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within small GTPase mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinocilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
    Names
    TIAM-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145886.1NP_001139358.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

      See identical proteins and their annotated locations for NP_001139358.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK017465, AK136856, AK147392, BC065126, CJ262109, CO042855
      Consensus CDS
      CCDS28314.1
      UniProtKB/TrEMBL
      G3UWG2, Q3UHH6, Q3UVX2, Q6P1D6
      Related
      ENSMUSP00000132137.2, ENSMUST00000163370.8
      Conserved Domains (6) summary
      smart00455
      Location:766832
      RBD; Raf-like Ras-binding domain
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    2. NM_001145887.1NP_001139359.1  rho guanine nucleotide exchange factor TIAM1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks many 5' coding exons, and initiates translation at an alternate start codon, compared to variant 1. This results in a shorter isoform (2) with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK136856, AK147392, BC065126, CJ262109, CO042855
      Consensus CDS
      CCDS49904.1
      UniProtKB/TrEMBL
      E9Q1R7, Q3UHH6, Q3UVX2, Q6P1D6
      Related
      ENSMUSP00000126020.3, ENSMUST00000164263.9
      Conserved Domains (3) summary
      smart00325
      Location:75264
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01255
      Location:266437
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam00169
      Location:314426
      PH; PH domain
    3. NM_009384.3NP_033410.2  rho guanine nucleotide exchange factor TIAM1 isoform 1

      See identical proteins and their annotated locations for NP_033410.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC122218, AK017465, AK136856, AK147392, BC065126, CJ262109, CO042855
      Consensus CDS
      CCDS28314.1
      UniProtKB/TrEMBL
      G3UWG2, Q3UHH6, Q3UVX2, Q6P1D6
      Related
      ENSMUSP00000002588.4, ENSMUST00000002588.11
      Conserved Domains (6) summary
      smart00455
      Location:766832
      RBD; Raf-like Ras-binding domain
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      89583999..89942488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522978.4XP_006523041.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006523041.1

      UniProtKB/TrEMBL
      G3UWG2
      Conserved Domains (6) summary
      smart00455
      Location:766832
      RBD; Raf-like Ras-binding domain
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    2. XM_017316936.2XP_017172425.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      UniProtKB/TrEMBL
      G3UWG2
      Conserved Domains (6) summary
      smart00455
      Location:766832
      RBD; Raf-like Ras-binding domain
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    3. XM_011246112.4XP_011244414.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244414.1

      UniProtKB/TrEMBL
      G3UWG2
      Conserved Domains (6) summary
      smart00455
      Location:766832
      RBD; Raf-like Ras-binding domain
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    4. XM_030249040.2XP_030104900.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      Conserved Domains (6) summary
      smart00455
      Location:766832
      RBD; Raf-like Ras-binding domain
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    5. XM_030249041.2XP_030104901.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      Conserved Domains (6) summary
      smart00455
      Location:766832
      RBD; Raf-like Ras-binding domain
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    6. XM_036159872.1XP_036015765.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      Conserved Domains (6) summary
      smart00455
      Location:766832
      RBD; Raf-like Ras-binding domain
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    7. XM_006522982.5XP_006523045.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006523045.1

      UniProtKB/TrEMBL
      G3UWG2
      Conserved Domains (6) summary
      smart00455
      Location:766832
      RBD; Raf-like Ras-binding domain
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    8. XM_006522980.5XP_006523043.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006523043.1

      UniProtKB/TrEMBL
      G3UWG2
      Conserved Domains (6) summary
      smart00455
      Location:766832
      RBD; Raf-like Ras-binding domain
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    9. XM_006522983.5XP_006523046.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X2

      Conserved Domains (6) summary
      smart00325
      Location:751940
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:553632
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:139265
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:9421113
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:473542
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:279376
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
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