Mapk7 mitogen-activated protein kinase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mapk7provided by MGI
Official Full Name: mitogen-activated protein kinase 7provided by MGI
Primary source: MGI:MGI:1346347
See related: Ensembl:ENSMUSG00000001034 AllianceGenome:MGI:1346347
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BMK1; ERK5; BMK-1; ERK-5; PRKM7; Erk5-T; b2b2346Clo
Summary: Enables protein serine/threonine kinase activity. Involved in protein phosphorylation. Acts upstream of or within several processes, including negative regulation of intracellular signal transduction; peptidyl-serine phosphorylation; and regulation of angiogenesis. Located in cytosol and nucleus. Is expressed in several structures, including cardiovascular system; early conceptus; ganglia; genitourinary system; and salivary gland. Orthologous to human MAPK7 (mitogen-activated protein kinase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 31.7), whole brain E14.5 (RPKM 29.9) and 27 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 11 B2; 11 37.96 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (61379638..61385101, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (61488812..61494267, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
Title: HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
Aerobic Exercise Alters the Melanoma Microenvironment and Modulates ERK5 S496 Phosphorylation.
Title: Aerobic Exercise Alters the Melanoma Microenvironment and Modulates ERK5 S496 Phosphorylation.
An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis.
Title: An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis.
Polarized macrophages promote gestational beta cell growth through extracellular signal-regulated kinase 5 signalling.
Title: Polarized macrophages promote gestational beta cell growth through extracellular signal-regulated kinase 5 signalling.
Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood.
Title: Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood.
ERK5 inhibitor BIX02189 attenuates methamphetamine-induced hyperactivity by modulating microglial activation in the striatum.
Title: ERK5 inhibitor BIX02189 attenuates methamphetamine-induced hyperactivity by modulating microglial activation in the striatum.
ERK5 negatively regulates Kruppel-like factor 4 and promotes osteogenic lineage cell proliferation in response to MEK5 overexpression or fluid shear stress.
Title: ERK5 negatively regulates Kruppel-like factor 4 and promotes osteogenic lineage cell proliferation in response to MEK5 overexpression or fluid shear stress.
An ERK5-KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells.
Title: An ERK5-KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells.
MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression.
Title: MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression.
Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner.
Title: Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner.

Submit: New GeneRIF Correction See all GeneRIFs (108)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Chemically induced (ENU) (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:236597

UniSTS:469818 (e-PCR)
- UniSTS:469818

Mapk7 (e-PCR), detects polymorphism
- UniSTS:469818

G67083 (e-PCR)
- UniSTS:178292

AB019373 (e-PCR)
- UniSTS:163503

STS-U29725 (e-PCR)
- UniSTS:72402

Mapk7 (e-PCR), detects polymorphism
- UniSTS:516574

PMC324396P2 (e-PCR)
- UniSTS:273128

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables MAP kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERK5 cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to laminar fluid shear stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: mitogen-activated protein kinase 7

Names: MAPK 7; big MAP kinase 1; extracellular signal-regulated kinase 5

NP_001277962.1

EC 2.7.11.24

NP_001277963.1

EC 2.7.11.24

NP_001277964.1

EC 2.7.11.24

NP_001277965.1

EC 2.7.11.24

NP_001277966.1

EC 2.7.11.24

NP_001348918.1

EC 2.7.11.24

NP_035971.1

EC 2.7.11.24

XP_006533340.1

EC 2.7.11.24

XP_006533343.1

EC 2.7.11.24

XP_006533347.1

EC 2.7.11.24

XP_006533348.1

EC 2.7.11.24

XP_006533349.1

EC 2.7.11.24

XP_030101845.1

EC 2.7.11.24

XP_030101846.1

EC 2.7.11.24

XP_030101847.1

EC 2.7.11.24

XP_030101848.1

EC 2.7.11.24

XP_030101849.1

EC 2.7.11.24

XP_030101850.1

EC 2.7.11.24

XP_030101851.1

EC 2.7.11.24

XP_030101853.1

EC 2.7.11.24

XP_036012575.1

EC 2.7.11.24

XP_036012576.1

EC 2.7.11.24

XP_036012577.1

EC 2.7.11.24

XP_036012578.1

EC 2.7.11.24

XP_036012579.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291033.1 → NP_001277962.1 mitogen-activated protein kinase 7 isoform b

See identical proteins and their annotated locations for NP_001277962.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in its 5' UTR uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a shorter and distinct N-terminus, compared to isoform a.

Source sequence(s)

AF126160, AY534740, BY207876

Consensus CDS

CCDS70205.1

UniProtKB/Swiss-Prot

Q9WVS8

Related

ENSMUSP00000104354.2, ENSMUST00000108714.2

Conserved Domains (1) summary

cd07855
Location:6 → 315

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
NM_001291034.1 → NP_001277963.1 mitogen-activated protein kinase 7 isoform a

See identical proteins and their annotated locations for NP_001277963.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AY534740, BC100398, BY207876

Consensus CDS

CCDS24814.1

UniProtKB/Swiss-Prot

Q3U2N7, Q3UG52, Q497T0, Q5NCN6, Q5NCN7, Q5NCN9, Q6QLU8, Q9R1D9, Q9WVF3, Q9WVF4, Q9WVS8

Conserved Domains (1) summary

cd07855
Location:49 → 384

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
NM_001291035.1 → NP_001277964.1 mitogen-activated protein kinase 7 isoform c

See identical proteins and their annotated locations for NP_001277964.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in its 5' UTR uses a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 4 and 5 encode the same isoform.

Source sequence(s)

AY534740, BC082315, BY207876

UniProtKB/Swiss-Prot

Q9WVS8

Related

ENSMUST00000152755.8

Conserved Domains (1) summary

cl21453
Location:1 → 245

PKc_like; Protein Kinases, catalytic domain
NM_001291036.1 → NP_001277965.1 mitogen-activated protein kinase 7 isoform c

See identical proteins and their annotated locations for NP_001277965.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in its 5' UTR uses a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 4 and 5 encode the same isoform.

Source sequence(s)

AY534740, BY207876, CA320276

UniProtKB/Swiss-Prot

Q9WVS8

Related

ENSMUST00000125840.8

Conserved Domains (1) summary

cl21453
Location:1 → 245

PKc_like; Protein Kinases, catalytic domain
NM_001291037.1 → NP_001277966.1 mitogen-activated protein kinase 7 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in its 5' UTR, uses an alternate start codon, and uses an alternate splice site in the central coding region, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AF126161, AY534740, BC058096, BY207876

Consensus CDS

CCDS78963.1

UniProtKB/TrEMBL

Q5NCN8

Related

ENSMUSP00000098646.3, ENSMUST00000101085.9

Conserved Domains (2) summary

smart00220
Location:8 → 277

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07855
Location:8 → 314

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
NM_001361989.1 → NP_001348918.1 mitogen-activated protein kinase 7 isoform c

Status: VALIDATED

Source sequence(s)

AY534740, BB868535, BC082315, CA315160

Conserved Domains (1) summary

cl21453
Location:1 → 245

PKc_like; Protein Kinases, catalytic domain
NM_011841.2 → NP_035971.1 mitogen-activated protein kinase 7 isoform a

See identical proteins and their annotated locations for NP_035971.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform.

Source sequence(s)

AY534740, BY207876

Consensus CDS

CCDS24814.1

UniProtKB/Swiss-Prot

Q3U2N7, Q3UG52, Q497T0, Q5NCN6, Q5NCN7, Q5NCN9, Q6QLU8, Q9R1D9, Q9WVF3, Q9WVF4, Q9WVS8

Related

ENSMUSP00000078087.7, ENSMUST00000079080.13

Conserved Domains (1) summary

cd07855
Location:49 → 384

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

61379638..61385101 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533277.5 → XP_006533340.1 mitogen-activated protein kinase 7 isoform X1

See identical proteins and their annotated locations for XP_006533340.1

UniProtKB/Swiss-Prot

Q3U2N7, Q3UG52, Q497T0, Q5NCN6, Q5NCN7, Q5NCN9, Q6QLU8, Q9R1D9, Q9WVF3, Q9WVF4, Q9WVS8

Conserved Domains (1) summary

cd07855
Location:49 → 384

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
XM_030245986.2 → XP_030101846.1 mitogen-activated protein kinase 7 isoform X2

Conserved Domains (1) summary

cd07855
Location:6 → 315

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
XM_030245993.2 → XP_030101853.1 mitogen-activated protein kinase 7 isoform X4

Conserved Domains (1) summary

cl21453
Location:1 → 245

PKc_like; Protein Kinases, catalytic domain
XM_030245989.2 → XP_030101849.1 mitogen-activated protein kinase 7 isoform X3

Conserved Domains (1) summary

cd07855
Location:8 → 314

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
XM_006533285.5 → XP_006533348.1 mitogen-activated protein kinase 7 isoform X4

See identical proteins and their annotated locations for XP_006533348.1

UniProtKB/Swiss-Prot

Q9WVS8

Conserved Domains (1) summary

cl21453
Location:1 → 245

PKc_like; Protein Kinases, catalytic domain
XM_036156683.1 → XP_036012576.1 mitogen-activated protein kinase 7 isoform X3

Conserved Domains (1) summary

cd07855
Location:8 → 314

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
XM_006533284.5 → XP_006533347.1 mitogen-activated protein kinase 7 isoform X4

See identical proteins and their annotated locations for XP_006533347.1

UniProtKB/Swiss-Prot

Q9WVS8

Conserved Domains (1) summary

cl21453
Location:1 → 245

PKc_like; Protein Kinases, catalytic domain
XM_030245987.2 → XP_030101847.1 mitogen-activated protein kinase 7 isoform X3

Conserved Domains (1) summary

cd07855
Location:8 → 314

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
XM_036156684.1 → XP_036012577.1 mitogen-activated protein kinase 7 isoform X4

Conserved Domains (1) summary

cl21453
Location:1 → 245

PKc_like; Protein Kinases, catalytic domain
XM_030245988.2 → XP_030101848.1 mitogen-activated protein kinase 7 isoform X3

Conserved Domains (1) summary

cd07855
Location:8 → 314

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
XM_006533286.5 → XP_006533349.1 mitogen-activated protein kinase 7 isoform X4

See identical proteins and their annotated locations for XP_006533349.1

UniProtKB/Swiss-Prot

Q9WVS8

Conserved Domains (1) summary

cl21453
Location:1 → 245

PKc_like; Protein Kinases, catalytic domain
XM_036156686.1 → XP_036012579.1 mitogen-activated protein kinase 7 isoform X4

Conserved Domains (1) summary

cl21453
Location:1 → 245

PKc_like; Protein Kinases, catalytic domain
XM_030245985.2 → XP_030101845.1 mitogen-activated protein kinase 7 isoform X2

Conserved Domains (1) summary

cd07855
Location:6 → 315

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
XM_036156685.1 → XP_036012578.1 mitogen-activated protein kinase 7 isoform X4

Conserved Domains (1) summary

cl21453
Location:1 → 245

PKc_like; Protein Kinases, catalytic domain
XM_036156682.1 → XP_036012575.1 mitogen-activated protein kinase 7 isoform X3

Conserved Domains (1) summary

cd07855
Location:8 → 314

STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
XM_030245990.2 → XP_030101850.1 mitogen-activated protein kinase 7 isoform X4

Conserved Domains (1) summary

cl21453
Location:1 → 245

PKc_like; Protein Kinases, catalytic domain
XM_030245991.2 → XP_030101851.1 mitogen-activated protein kinase 7 isoform X4

Conserved Domains (1) summary

cl21453
Location:1 → 245

PKc_like; Protein Kinases, catalytic domain
XM_006533280.5 → XP_006533343.1 mitogen-activated protein kinase 7 isoform X4

See identical proteins and their annotated locations for XP_006533343.1

UniProtKB/Swiss-Prot

Q9WVS8

Conserved Domains (1) summary

cl21453
Location:1 → 245

PKc_like; Protein Kinases, catalytic domain