Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ccl5 chemokine (C-C motif) ligand 5 [ Mus musculus (house mouse) ]

    Gene ID: 20304, updated on 24-May-2021

    Summary

    Official Symbol
    Ccl5provided by MGI
    Official Full Name
    chemokine (C-C motif) ligand 5provided by MGI
    Primary source
    MGI:MGI:98262
    See related
    Ensembl:ENSMUSG00000035042
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S; RA; Scy; MuRa; SISd; Scya5; TCP22; RANTES; TCP228; MuRantes
    Expression
    Biased expression in small intestine adult (RPKM 266.1), mammary gland adult (RPKM 266.0) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ccl5 in Genome Data Viewer
    Location:
    11 C; 11 50.66 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83416604..83421344, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83525778..83530518, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (83339280..83344020, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 15 Neighboring gene predicted gene, 32650 Neighboring gene HEAT repeat containing 9 Neighboring gene predicted gene, 23247 Neighboring gene chemokine (C-C motif) ligand 16, pseudogene Neighboring gene chemokine (C-C motif) ligand 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables CCR1 chemokine receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables CCR1 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables CCR5 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chemokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemokine receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein self-association ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor signaling protein tyrosine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within T-helper 1 cell diapedesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of phospholipase D activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interferon-gamma IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to interleukin-1 IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to tumor necrosis factor IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chemokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in eosinophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lymphocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within lymphocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of macrophage apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of T cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of T cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell-cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cellular biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of defense response to virus by host IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of fever generation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of homotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of mast cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of monocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of natural killer cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within pseudopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to cytokine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    C-C motif chemokine 5
    Names
    SIS-delta
    T-cell-specific protein RANTES
    small-inducible cytokine A5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013653.3NP_038681.2  C-C motif chemokine 5 precursor

      See identical proteins and their annotated locations for NP_038681.2

      Status: VALIDATED

      Source sequence(s)
      AK003101, BE333205
      Consensus CDS
      CCDS36254.1
      UniProtKB/Swiss-Prot
      P30882
      UniProtKB/TrEMBL
      Q5XZF2
      Related
      ENSMUSP00000039600.3, ENSMUST00000035938.3
      Conserved Domains (1) summary
      cd00272
      Location:3389
      Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      83416604..83421344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center