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    Gpr182 G protein-coupled receptor 182 [ Mus musculus (house mouse) ]

    Gene ID: 11536, updated on 7-May-2024

    Summary

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    Official Symbol
    Gpr182provided by MGI
    Official Full Name
    G protein-coupled receptor 182provided by MGI
    Primary source
    MGI:MGI:109545
    See related
    Ensembl:ENSMUSG00000058396 AllianceGenome:MGI:109545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NOW; AM-R; Admr; MB10; G10-D; Gpcr17; Gpcr22
    Summary
    Predicted to enable adrenomedullin receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system; gut; heart; reproductive system; and retina. Orthologous to human GPR182 (G protein-coupled receptor 182). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 41.9), spleen adult (RPKM 27.7) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr182 in Genome Data Viewer
    Location:
    10 D3; 10 75.07 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127585471..127587667, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127749602..127751798, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene tachykinin 2 Neighboring gene zinc finger and BTB domain containing 39 Neighboring gene STARR-seq mESC enhancer starr_28236 Neighboring gene retinol dehydrogenase 1 (all trans) Neighboring gene retinol dehydrogenase 9 Neighboring gene STARR-seq mESC enhancer starr_28237

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis. Le Mercier A, et al. Proc Natl Acad Sci U S A, 2021 Apr 27. PMID 33875597, Free PMC Article
    2. Adrenomedullin in mammalian embryogenesis. Garayoa M, et al. Microsc Res Tech, 2002 Apr 1. PMID 11921355
    3. Adrenomedullin expression in the mouse mammary gland: evidence for the mature form in milk. Jahnke GD, et al. J Mol Endocrinol, 1997 Dec. PMID 9460649
    4. Expression of adrenomedullin and its receptor during embryogenesis suggests autocrine or paracrine modes of action. Montuenga LM, et al. Endocrinology, 1997 Jan. PMID 8977434
    5. Cloning and expression of cDNA encoding a rat adrenomedullin receptor. Kapas S, et al. J Biol Chem, 1995 Oct 27. PMID 7592696

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity.
      Title: GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity.
    2. Gpr182 reduction led to increased activation of ERK1/2 in basal and challenge models, demonstrating a potential role for this orphan GPCR in regulating the proliferative capacity of the intestine.
      Title: Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation.
    3. ADMR mediates the stimulatory effects of adrenomedullin on cancer cells and on endothelial and stellate cells within the tumor microenvironment
      Title: The ADMR receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor microenvironment.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adrenomedullin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 182
    Names
    G10D
    adrenomedullin receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007412.2 → NP_031438.2  G-protein coupled receptor 182

      See identical proteins and their annotated locations for NP_031438.2

      Status: VALIDATED

      Source sequence(s)
      BB806742, BC125279, BY121440, BY590401
      Consensus CDS
      CCDS36084.1
      UniProtKB/Swiss-Prot
      P43142
      UniProtKB/TrEMBL
      G3X9R9
      Related
      ENSMUSP00000100882.3, ENSMUST00000079692.6
      Conserved Domains (1) summary
      cd14988
      Location:50 → 327
      7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127585471..127587667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43142.1 GenPept UniProtKB/Swiss-Prot:P43142

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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