Cd79a CD79A antigen (immunoglobulin-associated alpha) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd79aprovided by MGI
Official Full Name: CD79A antigen (immunoglobulin-associated alpha)provided by MGI
Primary source: MGI:MGI:101774
See related: Ensembl:ENSMUSG00000003379 AllianceGenome:MGI:101774
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Iga; Ly54; mb-1; Ly-54; Igalpha; Ig-alpha
Summary: Predicted to enable identical protein binding activity. Involved in B cell differentiation and B cell proliferation. Acts upstream of or within B cell receptor signaling pathway. Located in external side of plasma membrane; membrane raft; and multivesicular body. Part of B cell receptor complex. Is expressed in liver. Human ortholog(s) of this gene implicated in agammaglobulinemia. Orthologous to human CD79A (CD79a molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 536.2), mammary gland adult (RPKM 128.1) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 13.49 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (24596922..24601283)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (24897497..24901858)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BCR activation is accompanied by asymmetric conformational changes, possibly promoting the binding of Igalpha and Igbeta to differently localized signaling complexes
Title: Activation of the B cell receptor leads to increased membrane proximity of the Igα cytoplasmic domain.
CD79a myeloid cells showed enhanced ability to promote primary tumor growth and metastasis.
Title: Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects.
Data indicate that in the absence of DGKzeta, the threshold for B cell antigen receptor (BCR) signaling, measured as activation of the Ras-extracellular signal-regulated kinase (ERK) pathway, was markedly reduced in mature follicular B cells.
Title: Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses.
Data show that the B cell antigen receptor (BCR) and Igalpha may be required for B cell survival because they function as adaptor proteins in a BAFFR signaling pathway leading to activation of Syk, indicating crosstalk between the two receptors.
Title: The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.
The mouse B cell-specific mb-1 gene encodes an immunoreceptor tyrosine-based activation motif (ITAM) protein that may be evolutionarily conserved in diverse species by purifying selection.
Title: The mouse B cell-specific mb-1 gene encodes an immunoreceptor tyrosine-based activation motif (ITAM) protein that may be evolutionarily conserved in diverse species by purifying selection.
endocytosed BCR sequentially regulates MAPK and Akt signaling pathways from intracellular compartments
Title: Endocytosed BCRs sequentially regulate MAPK and Akt signaling pathways from intracellular compartments.
Data indicate that both the Igalpha and the Igbeta cytoplasmic domains alone are sufficient for trafficking to lysosomal compartments, and are unaffected by mutation of 4 amino acid residues within their respective ITAMs.
Title: The role of Ig-α/β in B cell antigen receptor internalization.
Arginine 198 in the tail of the Igalpha subunit of the BCR is methylated by the protein arginine methyltransferase 1. Methylation negatively regulates the calcium and PI-3 kinase pathways of the BCR, promoting signals leading to B cell differentiation.
Title: Arginine methylation of the B cell antigen receptor promotes differentiation.
MHC II structural requirements for mediation of cell death signaling in a murine B cell lymphoma with Igalpha/beta
Title: MHC class II structural requirements for the association with Igalpha/beta, and signaling of calcium mobilization and cell death.
Data show that expression of endogenous mb-1 transcripts correlates most closely with early-B-cell factor (EBF) expression and negatively with Id1, an inhibitor of E2A protein function, linking regulation of the mb-1 gene with EBF and E2A.
Title: Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (18) 1 citation
Chemically induced (ENU) (3) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cd79a (e-PCR), detects polymorphism
- UniSTS:265569

Cd79a (e-PCR), detects polymorphism
- UniSTS:256419

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in B cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of B cell receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of B cell receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of IgM B cell receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: B-cell antigen receptor complex-associated protein alpha chain

Names: MB-1 membrane glycoprotein; membrane-bound immunoglobulin-associated protein; surface IgM-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007655.4 → NP_031681.2 B-cell antigen receptor complex-associated protein alpha chain precursor

See identical proteins and their annotated locations for NP_031681.2

Status: VALIDATED

Source sequence(s)

AK143605, BB842272

Consensus CDS

CCDS20967.1

UniProtKB/Swiss-Prot

P11911, Q6GTY0

Related

ENSMUSP00000003469.8, ENSMUST00000003469.8

Conserved Domains (3) summary

smart00077
Location:179 → 199

ITAM; Immunoreceptor tyrosine-based activation motif

smart00410
Location:35 → 119

IG_like; Immunoglobulin like

pfam00047
Location:35 → 103

ig; Immunoglobulin domain