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    H2-Oa histocompatibility 2, O region alpha locus [ Mus musculus (house mouse) ]

    Gene ID: 15001, updated on 23-Jun-2021

    Summary

    Official Symbol
    H2-Oaprovided by MGI
    Official Full Name
    histocompatibility 2, O region alpha locusprovided by MGI
    Primary source
    MGI:MGI:95924
    See related
    Ensembl:ENSMUSG00000024334
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H-2; H-2Oa
    Expression
    Biased expression in spleen adult (RPKM 116.7), thymus adult (RPKM 40.6) and 3 other tissues See more
    Orthologs
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    Genomic context

    See H2-Oa in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34311353..34314286)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34092379..34095234)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34229324..34232179)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, P region beta locus Neighboring gene cDNA sequence BC051537 Neighboring gene histocompatibility 2, P region alpha locus Neighboring gene bromodomain containing 2 Neighboring gene histocompatibility 2, class II, locus DMa Neighboring gene histocompatibility 2, class II, locus Mb2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables MHC class II protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MHC class II protein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histocompatibility 2, O region alpha locus
    Names
    MHC class II antigen O region alpha locus

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008206.2NP_032232.2  histocompatibility 2, O region alpha locus precursor

      See identical proteins and their annotated locations for NP_032232.2

      Status: VALIDATED

      Source sequence(s)
      AK020594, BC138996, CO795887
      Consensus CDS
      CCDS37577.1
      UniProtKB/TrEMBL
      B2RST7, Q9QWV1
      Related
      ENSMUSP00000025192.8, ENSMUST00000025192.8
      Conserved Domains (3) summary
      cd05767
      Location:112205
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:30108
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      pfam16196
      Location:203250
      C1-set_C; C1-set C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34311353..34314286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160330.1XP_036016223.1  histocompatibility 2, O region alpha locus isoform X1

      Conserved Domains (2) summary
      pfam00993
      Location:178
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      cd21004
      Location:81175
      IgC1_MHC_II_alpha_HLA_DO; HLA class II histocompatibility antigen DO alpha; member of the C1-set of Ig superfamily (IgSF) domains
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