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    Fcrla Fc receptor-like A [ Mus musculus (house mouse) ]

    Gene ID: 98752, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fcrlaprovided by MGI
    Official Full Name
    Fc receptor-like Aprovided by MGI
    Primary source
    MGI:MGI:2138647
    See related
    Ensembl:ENSMUSG00000038421 AllianceGenome:MGI:2138647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FCRL; FREB; Fcrx; FCRL1; Freb1; mFREB; mFcrX; Fcrlm1
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway. Predicted to act upstream of or within cell differentiation. Predicted to be located in cytoplasm. Predicted to be integral component of plasma membrane. Is expressed in gut and male reproductive gland or organ. Orthologous to human FCRLA (Fc receptor like A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 43.6), mammary gland adult (RPKM 10.0) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fcrla in Genome Data Viewer
    Location:
    1 H3; 1 77.65 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170745163..170755169, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170917594..170932216, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 12 Neighboring gene STARR-seq mESC enhancer starr_02999 Neighboring gene STARR-positive B cell enhancer ABC_E7776 Neighboring gene STARR-positive B cell enhancer ABC_E5843 Neighboring gene STARR-positive B cell enhancer ABC_E11106 Neighboring gene STARR-positive B cell enhancer ABC_E4382 Neighboring gene STARR-positive B cell enhancer ABC_E4383 Neighboring gene Fc receptor-like B Neighboring gene STARR-positive B cell enhancer ABC_E3326 Neighboring gene STARR-positive B cell enhancer ABC_E5844 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9496 Neighboring gene STARR-positive B cell enhancer ABC_E4384 Neighboring gene STARR-seq mESC enhancer starr_03000 Neighboring gene predicted gene, 39701 Neighboring gene STARR-seq mESC enhancer starr_03002 Neighboring gene Fc receptor, IgG, low affinity IIb Neighboring gene STARR-positive B cell enhancer ABC_E2584

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential expression of FCRLA in naïve and activated mouse B cells. Reshetnikova ES, et al. Cell Immunol, 2012. PMID 22078318, Free PMC Article
    2. Dendritic cells transduced with autoantigen FCRLA induce cytotoxic lymphocytes and vaccinate against murine B-cell lymphoma. Inozume T, et al. J Invest Dermatol, 2007 Dec. PMID 17625599
    3. Fc receptor-like A associates with intracellular IgG and IgM but is dispensable for antigen-specific immune responses. Wilson TJ, et al. J Immunol, 2010 Sep 1. PMID 20668221
    4. Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells. Davis RS, et al. Int Immunol, 2002 Sep. PMID 12202404
    5. An unusual Fc receptor-related protein expressed in human centroblasts. Facchetti F, et al. Proc Natl Acad Sci U S A, 2002 Mar 19. PMID 11891275, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High expression of FCRLA in subset(s) of terminally differentiated B-cells suggests that, being an ER protein, FCRLA may participate in the regulation of immunoglobulin assembly and secretion.
      Title: Differential expression of FCRLA in naïve and activated mouse B cells.
    2. FcRLA protein is expressed exclusively in all mouse B cells, where it plays a role in immunoglobulin assembly that can be compensated for by other proteins.
      Title: Fc receptor-like A associates with intracellular IgG and IgM but is dispensable for antigen-specific immune responses.
    3. murine FCRLA (mFCRLA) is expressed and distributed in murine tissues similar to hFCRLA
      Title: Dendritic cells transduced with autoantigen FCRLA induce cytotoxic lymphocytes and vaccinate against murine B-cell lymphoma.
    4. may function as a secreted or intracellular protein in normal and neoplastic B cells
      Title: Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Fc receptor-like A
    Names
    Fc receptor related X
    Fc receptor related protein X
    Fc receptor-like mucin-like 1
    fc receptor homolog expressed in B-cells
    fc receptor-like and mucin-like protein 1
    fc receptor-like protein
    fc receptor-related protein X

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160215.1 → NP_001153687.1  Fc receptor-like A isoform 1 precursor

      See identical proteins and their annotated locations for NP_001153687.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BB219290, BC064708
      Consensus CDS
      CCDS48440.1
      UniProtKB/Swiss-Prot
      Q920A9
      Related
      ENSMUSP00000036380.8, ENSMUST00000046322.14
      Conserved Domains (3) summary
      smart00410
      Location:189 → 262
      IG_like; Immunoglobulin like
      pfam13927
      Location:182 → 253
      Ig_3; Immunoglobulin domain
      cl11960
      Location:90 → 176
      Ig; Immunoglobulin domain

    2. NM_145141.2 → NP_660123.1  Fc receptor-like A isoform 2 precursor

      See identical proteins and their annotated locations for NP_660123.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      BB219290, BB637253, BC064708
      Consensus CDS
      CCDS48439.1
      UniProtKB/Swiss-Prot
      Q3T9Q2, Q8K3U9, Q8VHP5, Q920A9
      Related
      ENSMUSP00000124853.2, ENSMUST00000159171.2
      Conserved Domains (3) summary
      smart00410
      Location:188 → 261
      IG_like; Immunoglobulin like
      pfam13927
      Location:181 → 252
      Ig_3; Immunoglobulin domain
      cl11960
      Location:89 → 175
      Ig; Immunoglobulin domain

    RNA

    1. NR_027666.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of an exon compared to variant 1. This creates an in-frame stop codon and makes this transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, this transcript is not thought to encode a protein.
      Source sequence(s)
      BB219290, BC064708, CJ080700

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      170745163..170755169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497072.4 → XP_006497135.1  Fc receptor-like A isoform X1

      Conserved Domains (2) summary
      pfam13927
      Location:121 → 191
      Ig_3; Immunoglobulin domain
      cl11960
      Location:28 → 114
      Ig; Immunoglobulin domain

    RNA

    1. XR_003947561.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920A9.1 GenPept UniProtKB/Swiss-Prot:Q920A9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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