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    Ramp3 receptor (calcitonin) activity modifying protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 56089, updated on 21-Apr-2024

    Summary

    Official Symbol
    Ramp3provided by MGI
    Official Full Name
    receptor (calcitonin) activity modifying protein 3provided by MGI
    Primary source
    MGI:MGI:1860292
    See related
    Ensembl:ENSMUSG00000041046 AllianceGenome:MGI:1860292
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables coreceptor activity. Involved in G protein-coupled receptor signaling pathway involved in heart process and cellular response to estradiol stimulus. Acts upstream of or within G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in alimentary system; central nervous system; heart; lung; and metanephros. Orthologous to human RAMP3 (receptor activity modifying protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in genital fat pad adult (RPKM 64.0), subcutaneous fat pad adult (RPKM 53.0) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    11 A1; 11 4.61 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6608507..6627478)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6658506..6677478)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transforming growth factor beta regulated gene 4 Neighboring gene small nucleolar RNA, H/ACA box 5C Neighboring gene whey acidic protein Neighboring gene predicted gene 11978 Neighboring gene lactate dehydrogenase A pseudogene Neighboring gene predicted gene, 39575

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adrenomedullin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amylin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables coreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables coreceptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables coreceptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway involved in heart process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adrenomedullin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amylin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to estradiol stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cross-receptor inhibition within G protein-coupled receptor heterodimer ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of adrenomedullin receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of amylin receptor complex 3 ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    receptor activity-modifying protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019511.3NP_062384.1  receptor activity-modifying protein 3 precursor

      See identical proteins and their annotated locations for NP_062384.1

      Status: VALIDATED

      Source sequence(s)
      AL603787
      Consensus CDS
      CCDS24425.1
      UniProtKB/Swiss-Prot
      Q5SWP4, Q9WUP1
      Related
      ENSMUSP00000047518.8, ENSMUST00000045374.8
      Conserved Domains (1) summary
      pfam04901
      Location:37144
      RAMP; Receptor activity modifying family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      6608507..6627478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514761.5XP_006514824.1  receptor activity-modifying protein 3 isoform X1

      Related
      ENSMUST00000139540.2
      Conserved Domains (1) summary
      pfam04901
      Location:6113
      RAMP; Receptor activity modifying family