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    Nptx2 neuronal pentraxin 2 [ Mus musculus (house mouse) ]

    Gene ID: 53324, updated on 11-Apr-2024

    Summary

    Official Symbol
    Nptx2provided by MGI
    Official Full Name
    neuronal pentraxin 2provided by MGI
    Primary source
    MGI:MGI:1858209
    See related
    Ensembl:ENSMUSG00000059991 AllianceGenome:MGI:1858209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    np2; Narp
    Summary
    Predicted to enable carbohydrate binding activity and metal ion binding activity. Acts upstream of or within associative learning. Predicted to be located in extracellular region. Predicted to be active in glutamatergic synapse. Is expressed in embryo; gut endoderm; and heart. Orthologous to human NPTX2 (neuronal pentraxin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cortex adult (RPKM 14.8), frontal lobe adult (RPKM 13.5) and 17 other tissues See more
    Orthologs
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    Genomic context

    Location:
    5 G2; 5 84.58 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (144482697..144494288)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (144545887..144557478)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14813 Neighboring gene predicted gene, 33714 Neighboring gene predicted gene, 33765 Neighboring gene STARR-seq mESC enhancer starr_14815 Neighboring gene predicted gene, 54313 Neighboring gene STARR-seq mESC enhancer starr_14816 Neighboring gene STARR-seq mESC enhancer starr_14818 Neighboring gene predicted pseudogene 6272

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extrinsic component of postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in synaptic cleft ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    neuronal pentraxin-2
    Names
    NP-II
    neuro activity regulated petaxin
    neuronal pentraxin II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016789.3NP_058069.1  neuronal pentraxin-2 precursor

      See identical proteins and their annotated locations for NP_058069.1

      Status: VALIDATED

      Source sequence(s)
      AC164119, AK134806, DV649643
      Consensus CDS
      CCDS19849.1
      UniProtKB/Swiss-Prot
      O70340
      UniProtKB/TrEMBL
      Q3UYB9
      Related
      ENSMUSP00000071687.7, ENSMUST00000071782.8
      Conserved Domains (2) summary
      smart00159
      Location:217422
      PTX; Pentraxin / C-reactive protein / pentaxin family
      cl03951
      Location:66185
      CDC37_N; Cdc37 N terminal kinase binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      144482697..144494288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)