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    Apc APC, WNT signaling pathway regulator [ Mus musculus (house mouse) ]

    Gene ID: 11789, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Apcprovided by MGI
    Official Full Name
    APC, WNT signaling pathway regulatorprovided by MGI
    Primary source
    MGI:MGI:88039
    See related
    Ensembl:ENSMUSG00000005871 AllianceGenome:MGI:88039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CC1; Min; mAPC
    Summary
    Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and enzyme binding activity. Involved in insulin receptor signaling pathway; positive regulation of cold-induced thermogenesis; and positive regulation of protein localization to centrosome. Acts upstream of or within several processes, including animal organ development; regionalization; and regulation of microtubule polymerization or depolymerization. Located in several cellular components, including axonal growth cone; cell projection membrane; and microtubule cytoskeleton. Part of Scrib-APC-beta-catenin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and retina. Used to study breast cancer; familial adenomatous polyposis; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of WNT signaling pathway). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 29.9), CNS E18 (RPKM 22.5) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Apc in Genome Data Viewer
    Location:
    18 B1; 18 18.53 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34353350..34455243)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34220297..34322190)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41686 Neighboring gene predicted gene, 23411 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:34380446-34380555 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44199 Neighboring gene predicted gene, 54017 Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lentiviral in situ targeting of stem cells in unperturbed intestinal epithelium. Garside GB, et al. BMC Biol, 2023 Jan 11. PMID 36627630, Free PMC Article
    2. Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells. Kitchen-Goosen SM, et al. Carcinogenesis, 2023 May 15. PMID 36548952, Free PMC Article
    3. Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients. Zhao L, et al. Oncogene, 2022 Sep. PMID 35882981, Free PMC Article
    4. A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine. Sebastian C, et al. Nat Commun, 2022 Mar 21. PMID 35314684, Free PMC Article
    5. Emodin reduces tumor burden by diminishing M2-like macrophages in colorectal cancer. Sougiannis AT, et al. Am J Physiol Gastrointest Liver Physiol, 2022 Mar 1. PMID 35018819, Free PMC Article

    See all (1782) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model.
      Title: Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model.
    2. Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth.
      Title: Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth.
    3. Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage in murine gastric stem and progenitor cells.
      Title: Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage in murine gastric stem and progenitor cells.
    4. Role of Reduced Bdnf Expression in Novel Apc Mutant Allele-induced Intestinal and Colonic Tumorigenesis in Mice.
      Title: Role of Reduced Bdnf Expression in Novel Apc Mutant Allele-induced Intestinal and Colonic Tumorigenesis in Mice.
    5. Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells.
      Title: Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells.
    6. LAT1 expression influences Paneth cell number and tumor development in Apc[Min/+] mice.
      Title: LAT1 expression influences Paneth cell number and tumor development in Apc(Min/+) mice.
    7. Rare Genetic Variants in Human APC Are Implicated in Mesiodens and Isolated Supernumerary Teeth.
      Title: Rare Genetic Variants in Human APC Are Implicated in Mesiodens and Isolated Supernumerary Teeth.
    8. USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development.
      Title: USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development.
    9. HER2 and APC Mutations Promote Altered Crypt-Villus Morphology and Marked Hyperplasia in the Intestinal Epithelium.
      Title: HER2 and APC Mutations Promote Altered Crypt-Villus Morphology and Marked Hyperplasia in the Intestinal Epithelium.
    10. Mutant APC promotes tumor immune evasion via PD-L1 in colorectal cancer.
      Title: Mutant APC promotes tumor immune evasion via PD-L1 in colorectal cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (229)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (27)  1 citation
    • Chemically induced (ENU) (2)  1 citation
    • Endonuclease-mediated (7) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables gamma-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of acinar cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of acinar cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within canonical Wnt signaling pathway involved in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within canonical Wnt signaling pathway involved in positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chromosome organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytoplasmic microtubule organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of endothelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of epithelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of epithelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of epithelial cell proliferation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of fibroblast apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within muscle cell cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of acinar cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of acinar cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of endothelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of odontogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of odontogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pattern specification process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of fibroblast apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of pseudopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of glutamate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of nitrogen compound metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skin development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within somatic stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thymus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Scrib-APC-beta-catenin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of beta-catenin destruction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of beta-catenin destruction complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of beta-catenin destruction complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell body fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenomatous polyposis coli protein
    Names
    adenomatosis polyposis coli
    multiple intestinal neoplasia

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360979.1 → NP_001347908.1  adenomatous polyposis coli protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC090534, AC114003, AL591373
      UniProtKB/Swiss-Prot
      Q61315, Q62044
      Conserved Domains (15) summary
      smart00185
      Location:588 → 628
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:404 → 447
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:630 → 668
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1576 → 1599
      APC_r; APC repeat
      pfam05924
      Location:1973 → 1992
      SAMP; SAMP Motif
      pfam05937
      Location:2611 → 2783
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2164 → 2509
      APC_basic; APC basic domain
      pfam11414
      Location:66 → 146
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:671 → 958
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:975 → 1074
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1222 → 1308
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1601 → 1654
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1685 → 1778
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1812 → 1886
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:332 → 405
      APC_rep; Adenomatous polyposis coli (APC) repeat

    2. NM_001360980.1 → NP_001347909.1  adenomatous polyposis coli protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC090534, AC114003, AL591373
      UniProtKB/Swiss-Prot
      Q61315, Q62044
      Conserved Domains (16) summary
      smart00185
      Location:665 → 705
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:579 → 611
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:707 → 745
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1653 → 1676
      APC_r; APC repeat
      pfam05924
      Location:2050 → 2069
      SAMP; SAMP Motif
      pfam05937
      Location:2688 → 2860
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2241 → 2586
      APC_basic; APC basic domain
      pfam11414
      Location:125 → 205
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:748 → 1035
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1052 → 1151
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1299 → 1385
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1678 → 1731
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1762 → 1855
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1889 → 1963
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      pfam18797
      Location:391 → 464
      APC_rep; Adenomatous polyposis coli (APC) repeat

    3. NM_001402727.1 → NP_001389656.1  adenomatous polyposis coli protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC090534, AC114003, AL591373

    4. NM_001402728.1 → NP_001389657.1  adenomatous polyposis coli protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC090534, AC114003, AL591373

    5. NM_001402729.1 → NP_001389658.1  adenomatous polyposis coli protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC090534, AC114003, AL591373

    6. NM_001402730.1 → NP_001389659.1  adenomatous polyposis coli protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC090534, AC114003, AL591373

    7. NM_001402731.1 → NP_001389660.1  adenomatous polyposis coli protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC090534, AC114003, AL591373
      UniProtKB/TrEMBL
      B2RUG9

    8. NM_001402732.1 → NP_001389661.1  adenomatous polyposis coli protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC090534, AC114003, AL591373

    9. NM_001402733.1 → NP_001389662.1  adenomatous polyposis coli protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC090534, AC114003, AL591373

    10. NM_001402734.1 → NP_001389663.1  adenomatous polyposis coli protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC090534, AC114003, AL591373

    11. NM_001402735.1 → NP_001389664.1  adenomatous polyposis coli protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC090534, AC114003, AL591373

    12. NM_001402736.1 → NP_001389665.1  adenomatous polyposis coli protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC090534, AC114003, AL591373

    13. NM_001402737.1 → NP_001389666.1  adenomatous polyposis coli protein isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC090534, AC114003, AL591373

    14. NM_001402738.1 → NP_001389667.1  adenomatous polyposis coli protein isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC090534, AC114003, AL591373

    15. NM_001402739.1 → NP_001389668.1  adenomatous polyposis coli protein isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC090534, AC114003, AL591373
      Related
      ENSMUSP00000111447.4, ENSMUST00000115781.10

    16. NM_001402740.1 → NP_001389669.1  adenomatous polyposis coli protein isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC090534, AC114003, AL591373

    17. NM_007462.4 → NP_031488.2  adenomatous polyposis coli protein isoform 3

      See identical proteins and their annotated locations for NP_031488.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AC090534, AC114003, AL591373
      Consensus CDS
      CCDS29125.1
      UniProtKB/Swiss-Prot
      Q61315, Q62044
      UniProtKB/TrEMBL
      B2RUG9
      Related
      ENSMUSP00000078337.6, ENSMUST00000079362.13
      Conserved Domains (16) summary
      smart00185
      Location:647 → 687
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:463 → 506
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:689 → 727
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1635 → 1658
      APC_r; APC repeat
      pfam05924
      Location:2032 → 2051
      SAMP; SAMP Motif
      pfam05937
      Location:2670 → 2842
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2223 → 2568
      APC_basic; APC basic domain
      pfam11414
      Location:125 → 205
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:730 → 1017
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1034 → 1133
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1281 → 1367
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1660 → 1713
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1744 → 1837
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1871 → 1945
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      pfam18797
      Location:391 → 464
      APC_rep; Adenomatous polyposis coli (APC) repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      34353350..34455243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525529.4 → XP_006525592.1  adenomatous polyposis coli protein isoform X1

      UniProtKB/Swiss-Prot
      Q61315, Q62044
      Conserved Domains (15) summary
      smart00185
      Location:675 → 715
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:589 → 621
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:717 → 755
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1663 → 1686
      APC_r; APC repeat
      pfam05924
      Location:2060 → 2079
      SAMP; SAMP Motif
      pfam05937
      Location:2698 → 2870
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2251 → 2596
      APC_basic; APC basic domain
      pfam11414
      Location:135 → 215
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:758 → 1045
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1062 → 1161
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1309 → 1395
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1688 → 1741
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1772 → 1865
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1899 → 1973
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:401 → 474
      APC_rep; Adenomatous polyposis coli (APC) repeat

    2. XM_006525538.4 → XP_006525601.1  adenomatous polyposis coli protein isoform X15

      UniProtKB/Swiss-Prot
      Q61315, Q62044
      Conserved Domains (15) summary
      smart00185
      Location:574 → 614
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:488 → 520
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:616 → 654
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1562 → 1585
      APC_r; APC repeat
      pfam05924
      Location:1959 → 1978
      SAMP; SAMP Motif
      pfam05937
      Location:2597 → 2769
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2150 → 2495
      APC_basic; APC basic domain
      pfam11414
      Location:135 → 215
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:657 → 944
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:961 → 1060
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1208 → 1294
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1587 → 1640
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1671 → 1764
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1798 → 1872
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:315 → 373
      APC_rep; Adenomatous polyposis coli (APC) repeat

    3. XM_006525534.4 → XP_006525597.1  adenomatous polyposis coli protein isoform X6

      UniProtKB/TrEMBL
      E9QLQ9
      Conserved Domains (15) summary
      smart00185
      Location:640 → 680
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:554 → 586
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:682 → 720
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1628 → 1651
      APC_r; APC repeat
      pfam05924
      Location:2025 → 2044
      SAMP; SAMP Motif
      pfam05937
      Location:2663 → 2835
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2216 → 2561
      APC_basic; APC basic domain
      pfam11414
      Location:135 → 215
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:723 → 1010
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1027 → 1126
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1274 → 1360
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1653 → 1706
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1737 → 1830
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1864 → 1938
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:366 → 439
      APC_rep; Adenomatous polyposis coli (APC) repeat

    4. XM_036160948.1 → XP_036016841.1  adenomatous polyposis coli protein isoform X21

      UniProtKB/TrEMBL
      E9QLQ9
      Conserved Domains (15) summary
      smart00185
      Location:539 → 579
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:453 → 485
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:581 → 621
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1527 → 1550
      APC_r; APC repeat
      pfam05924
      Location:1924 → 1943
      SAMP; SAMP Motif
      pfam05937
      Location:2562 → 2734
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2115 → 2460
      APC_basic; APC basic domain
      pfam11414
      Location:135 → 215
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:622 → 909
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:926 → 1025
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1173 → 1259
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1552 → 1605
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1636 → 1729
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1763 → 1837
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:280 → 338
      APC_rep; Adenomatous polyposis coli (APC) repeat

    5. XM_036160950.1 → XP_036016843.1  adenomatous polyposis coli protein isoform X24

      UniProtKB/TrEMBL
      E9QLQ9
      Conserved Domains (15) summary
      smart00185
      Location:521 → 561
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:337 → 380
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:563 → 603
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1509 → 1532
      APC_r; APC repeat
      pfam05924
      Location:1906 → 1925
      SAMP; SAMP Motif
      pfam05937
      Location:2544 → 2716
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2097 → 2442
      APC_basic; APC basic domain
      pfam11414
      Location:135 → 215
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:604 → 891
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:908 → 1007
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1155 → 1241
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1534 → 1587
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1618 → 1711
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1745 → 1819
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:280 → 338
      APC_rep; Adenomatous polyposis coli (APC) repeat

    6. XM_030250280.1 → XP_030106140.1  adenomatous polyposis coli protein isoform X9

      UniProtKB/TrEMBL
      E9QLQ9
      Conserved Domains (15) summary
      smart00185
      Location:622 → 662
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:438 → 481
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:664 → 702
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1610 → 1633
      APC_r; APC repeat
      pfam05924
      Location:2007 → 2026
      SAMP; SAMP Motif
      pfam05937
      Location:2645 → 2817
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2198 → 2543
      APC_basic; APC basic domain
      pfam11414
      Location:135 → 215
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:705 → 992
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1009 → 1108
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1256 → 1342
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1635 → 1688
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1719 → 1812
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1846 → 1920
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:366 → 439
      APC_rep; Adenomatous polyposis coli (APC) repeat

    7. XM_036160951.1 → XP_036016844.1  adenomatous polyposis coli protein isoform X25

      UniProtKB/TrEMBL
      E9QLQ9
      Conserved Domains (16) summary
      smart00185
      Location:511 → 551
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:327 → 370
      ARM; armadillo repeat [structural motif]
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      pfam00514
      Location:553 → 593
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1499 → 1522
      APC_r; APC repeat
      pfam05924
      Location:1896 → 1915
      SAMP; SAMP Motif
      pfam05937
      Location:2534 → 2706
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2087 → 2432
      APC_basic; APC basic domain
      pfam11414
      Location:125 → 205
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:594 → 881
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:898 → 997
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1145 → 1231
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1524 → 1577
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1608 → 1701
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1735 → 1809
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:270 → 328
      APC_rep; Adenomatous polyposis coli (APC) repeat

    8. XM_006525539.4 → XP_006525602.1  adenomatous polyposis coli protein isoform X20

      UniProtKB/Swiss-Prot
      Q61315, Q62044
      Conserved Domains (16) summary
      smart00185
      Location:546 → 586
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:362 → 405
      ARM; armadillo repeat [structural motif]
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      pfam00514
      Location:588 → 628
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1534 → 1557
      APC_r; APC repeat
      pfam05924
      Location:1931 → 1950
      SAMP; SAMP Motif
      pfam05937
      Location:2569 → 2741
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2122 → 2467
      APC_basic; APC basic domain
      pfam11414
      Location:125 → 205
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:629 → 916
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:933 → 1032
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1180 → 1266
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1559 → 1612
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1643 → 1736
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1770 → 1844
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:305 → 363
      APC_rep; Adenomatous polyposis coli (APC) repeat

    9. XM_030250281.2 → XP_030106141.1  adenomatous polyposis coli protein isoform X10

      UniProtKB/TrEMBL
      E9QLQ9
      Conserved Domains (16) summary
      smart00185
      Location:612 → 652
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:428 → 471
      ARM; armadillo repeat [structural motif]
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      pfam00514
      Location:654 → 694
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1600 → 1623
      APC_r; APC repeat
      pfam05924
      Location:1997 → 2016
      SAMP; SAMP Motif
      pfam05937
      Location:2635 → 2807
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2188 → 2533
      APC_basic; APC basic domain
      pfam11414
      Location:125 → 205
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:695 → 982
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:999 → 1098
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1246 → 1332
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1625 → 1678
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1709 → 1802
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1836 → 1910
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:356 → 429
      APC_rep; Adenomatous polyposis coli (APC) repeat

    10. XM_030250288.1 → XP_030106148.1  adenomatous polyposis coli protein isoform X16

      UniProtKB/TrEMBL
      E9QLQ9
      Conserved Domains (15) summary
      smart00185
      Location:571 → 611
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:485 → 517
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:613 → 651
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1559 → 1582
      APC_r; APC repeat
      pfam05924
      Location:1956 → 1975
      SAMP; SAMP Motif
      pfam05937
      Location:2594 → 2766
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2147 → 2492
      APC_basic; APC basic domain
      pfam11414
      Location:66 → 146
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:654 → 941
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:958 → 1057
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1205 → 1291
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1584 → 1637
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1668 → 1761
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1795 → 1869
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:297 → 370
      APC_rep; Adenomatous polyposis coli (APC) repeat

    11. XM_030250283.1 → XP_030106143.1  adenomatous polyposis coli protein isoform X12

      UniProtKB/Swiss-Prot
      Q61315, Q62044
      Conserved Domains (15) summary
      smart00185
      Location:606 → 646
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:520 → 552
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:648 → 688
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1594 → 1617
      APC_r; APC repeat
      pfam05924
      Location:1991 → 2010
      SAMP; SAMP Motif
      pfam05937
      Location:2629 → 2801
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2182 → 2527
      APC_basic; APC basic domain
      pfam11414
      Location:66 → 146
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:689 → 976
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:993 → 1092
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1240 → 1326
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1619 → 1672
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1703 → 1796
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1830 → 1904
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:332 → 405
      APC_rep; Adenomatous polyposis coli (APC) repeat

    12. XM_036160952.1 → XP_036016845.1  adenomatous polyposis coli protein isoform X26

      UniProtKB/Swiss-Prot
      Q61315, Q62044
      Conserved Domains (15) summary
      smart00185
      Location:487 → 527
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:303 → 346
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:529 → 569
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1475 → 1498
      APC_r; APC repeat
      pfam05924
      Location:1872 → 1891
      SAMP; SAMP Motif
      pfam05937
      Location:2510 → 2682
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2063 → 2408
      APC_basic; APC basic domain
      pfam11414
      Location:66 → 146
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:570 → 857
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:874 → 973
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1121 → 1207
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1500 → 1553
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1584 → 1677
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1711 → 1785
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:246 → 304
      APC_rep; Adenomatous polyposis coli (APC) repeat

    13. XM_030250278.2 → XP_030106138.1  adenomatous polyposis coli protein isoform X7

      UniProtKB/TrEMBL
      E9QLQ9
      Conserved Domains (16) summary
      smart00185
      Location:630 → 670
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:544 → 576
      ARM; armadillo repeat [structural motif]
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      pfam00514
      Location:672 → 712
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1618 → 1641
      APC_r; APC repeat
      pfam05924
      Location:2015 → 2034
      SAMP; SAMP Motif
      pfam05937
      Location:2653 → 2825
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2206 → 2551
      APC_basic; APC basic domain
      pfam11414
      Location:125 → 205
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:713 → 1000
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1017 → 1116
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1264 → 1350
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1643 → 1696
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1727 → 1820
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1854 → 1928
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:356 → 429
      APC_rep; Adenomatous polyposis coli (APC) repeat

    14. XM_030250291.1 → XP_030106151.1  adenomatous polyposis coli protein isoform X18

      UniProtKB/Swiss-Prot
      Q61315, Q62044
      Conserved Domains (15) summary
      smart00185
      Location:556 → 596
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:372 → 415
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:598 → 636
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1544 → 1567
      APC_r; APC repeat
      pfam05924
      Location:1941 → 1960
      SAMP; SAMP Motif
      pfam05937
      Location:2579 → 2751
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2132 → 2477
      APC_basic; APC basic domain
      pfam11414
      Location:135 → 215
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:639 → 926
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:943 → 1042
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1190 → 1276
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1569 → 1622
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1653 → 1746
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1780 → 1854
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:315 → 373
      APC_rep; Adenomatous polyposis coli (APC) repeat

    15. XM_036160946.1 → XP_036016839.1  adenomatous polyposis coli protein isoform X12

      UniProtKB/Swiss-Prot
      Q61315, Q62044
      Conserved Domains (15) summary
      smart00185
      Location:606 → 646
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:520 → 552
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:648 → 688
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1594 → 1617
      APC_r; APC repeat
      pfam05924
      Location:1991 → 2010
      SAMP; SAMP Motif
      pfam05937
      Location:2629 → 2801
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2182 → 2527
      APC_basic; APC basic domain
      pfam11414
      Location:66 → 146
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:689 → 976
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:993 → 1092
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1240 → 1326
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1619 → 1672
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1703 → 1796
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1830 → 1904
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:332 → 405
      APC_rep; Adenomatous polyposis coli (APC) repeat

    16. XM_030250293.2 → XP_030106153.1  adenomatous polyposis coli protein isoform X22

      UniProtKB/TrEMBL
      E9QLQ9
      Conserved Domains (17) summary
      smart00185
      Location:529 → 569
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:443 → 475
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:571 → 609
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1517 → 1540
      APC_r; APC repeat
      pfam05924
      Location:1914 → 1933
      SAMP; SAMP Motif
      pfam05937
      Location:2552 → 2724
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2105 → 2450
      APC_basic; APC basic domain
      pfam11414
      Location:125 → 205
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:612 → 899
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:916 → 1015
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1163 → 1249
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1542 → 1595
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1626 → 1719
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1753 → 1827
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      pfam18797
      Location:270 → 328
      APC_rep; Adenomatous polyposis coli (APC) repeat
      cl00755
      Location:172 → 296
      zf-dskA_traR; Prokaryotic dksA/traR C4-type zinc finger

    17. XM_030250282.2 → XP_030106142.1  adenomatous polyposis coli protein isoform X11

      UniProtKB/TrEMBL
      E9QLQ9
      Conserved Domains (15) summary
      smart00185
      Location:610 → 650
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:524 → 556
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:652 → 690
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1598 → 1621
      APC_r; APC repeat
      pfam05924
      Location:1995 → 2014
      SAMP; SAMP Motif
      pfam05937
      Location:2633 → 2805
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2186 → 2531
      APC_basic; APC basic domain
      pfam11414
      Location:105 → 185
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:693 → 980
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:997 → 1096
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1244 → 1330
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1623 → 1676
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1707 → 1800
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1834 → 1908
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:336 → 409
      APC_rep; Adenomatous polyposis coli (APC) repeat

    18. XM_006525533.4 → XP_006525596.1  adenomatous polyposis coli protein isoform X5

      UniProtKB/Swiss-Prot
      Q61315, Q62044
      Conserved Domains (15) summary
      smart00185
      Location:645 → 685
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:559 → 591
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:687 → 725
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1633 → 1656
      APC_r; APC repeat
      pfam05924
      Location:2030 → 2049
      SAMP; SAMP Motif
      pfam05937
      Location:2668 → 2840
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2221 → 2566
      APC_basic; APC basic domain
      pfam11414
      Location:105 → 185
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:728 → 1015
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1032 → 1131
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1279 → 1365
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1658 → 1711
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1742 → 1835
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1869 → 1943
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:371 → 444
      APC_rep; Adenomatous polyposis coli (APC) repeat

    19. XM_030250289.2 → XP_030106149.1  adenomatous polyposis coli protein isoform X16

      UniProtKB/TrEMBL
      E9QLQ9
      Conserved Domains (15) summary
      smart00185
      Location:571 → 611
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:485 → 517
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:613 → 651
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1559 → 1582
      APC_r; APC repeat
      pfam05924
      Location:1956 → 1975
      SAMP; SAMP Motif
      pfam05937
      Location:2594 → 2766
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2147 → 2492
      APC_basic; APC basic domain
      pfam11414
      Location:66 → 146
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:654 → 941
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:958 → 1057
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1205 → 1291
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1584 → 1637
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1668 → 1761
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1795 → 1869
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:297 → 370
      APC_rep; Adenomatous polyposis coli (APC) repeat

    20. XM_006525536.5 → XP_006525599.1  adenomatous polyposis coli protein isoform X12

      See identical proteins and their annotated locations for XP_006525599.1

      UniProtKB/Swiss-Prot
      Q61315, Q62044
      Conserved Domains (15) summary
      smart00185
      Location:606 → 646
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:520 → 552
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:648 → 688
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1594 → 1617
      APC_r; APC repeat
      pfam05924
      Location:1991 → 2010
      SAMP; SAMP Motif
      pfam05937
      Location:2629 → 2801
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2182 → 2527
      APC_basic; APC basic domain
      pfam11414
      Location:66 → 146
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:689 → 976
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:993 → 1092
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1240 → 1326
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1619 → 1672
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1703 → 1796
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1830 → 1904
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:332 → 405
      APC_rep; Adenomatous polyposis coli (APC) repeat

    21. XM_030250292.2 → XP_030106152.1  adenomatous polyposis coli protein isoform X19

      UniProtKB/TrEMBL
      E9QLQ9
      Conserved Domains (15) summary
      smart00185
      Location:553 → 593
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:369 → 412
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:595 → 633
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1541 → 1564
      APC_r; APC repeat
      pfam05924
      Location:1938 → 1957
      SAMP; SAMP Motif
      pfam05937
      Location:2576 → 2748
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2129 → 2474
      APC_basic; APC basic domain
      pfam11414
      Location:66 → 146
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:636 → 923
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:940 → 1039
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1187 → 1273
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1566 → 1619
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1650 → 1743
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1777 → 1851
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:297 → 370
      APC_rep; Adenomatous polyposis coli (APC) repeat

    22. XM_030250284.2 → XP_030106144.1  adenomatous polyposis coli protein isoform X12

      UniProtKB/Swiss-Prot
      Q61315, Q62044
      Conserved Domains (15) summary
      smart00185
      Location:606 → 646
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:520 → 552
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:648 → 688
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1594 → 1617
      APC_r; APC repeat
      pfam05924
      Location:1991 → 2010
      SAMP; SAMP Motif
      pfam05937
      Location:2629 → 2801
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2182 → 2527
      APC_basic; APC basic domain
      pfam11414
      Location:66 → 146
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:689 → 976
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:993 → 1092
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1240 → 1326
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1619 → 1672
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1703 → 1796
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1830 → 1904
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:332 → 405
      APC_rep; Adenomatous polyposis coli (APC) repeat

    23. XM_030250295.2 → XP_030106155.1  adenomatous polyposis coli protein isoform X26

      UniProtKB/Swiss-Prot
      Q61315, Q62044
      Conserved Domains (15) summary
      smart00185
      Location:487 → 527
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:303 → 346
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:529 → 569
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1475 → 1498
      APC_r; APC repeat
      pfam05924
      Location:1872 → 1891
      SAMP; SAMP Motif
      pfam05937
      Location:2510 → 2682
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2063 → 2408
      APC_basic; APC basic domain
      pfam11414
      Location:66 → 146
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:570 → 857
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:874 → 973
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1121 → 1207
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1500 → 1553
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1584 → 1677
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1711 → 1785
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam18797
      Location:246 → 304
      APC_rep; Adenomatous polyposis coli (APC) repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61315.1 GenPept UniProtKB/Swiss-Prot:Q61315

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