Angptl2 angiopoietin-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Angptl2provided by MGI
Official Full Name: angiopoietin-like 2provided by MGI
Primary source: MGI:MGI:1347002
See related: Ensembl:ENSMUSG00000004105 AllianceGenome:MGI:1347002
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arp2
Summary: Predicted to enable signaling receptor binding activity. Located in extracellular space. Is expressed in several structures, including intraembryonic coelom; limb segment; meninges; s-shaped body; and skeleton. Used to study dermatomyositis. Orthologous to human ANGPTL2 (angiopoietin like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in mammary gland adult (RPKM 99.1), subcutaneous fat pad adult (RPKM 61.8) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 22.36 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (33105963..33137737)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (33215951..33247725)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANGPTL2-mediated epigenetic repression of MHC-I in tumor cells accelerates tumor immune evasion.
Title: ANGPTL2-mediated epigenetic repression of MHC-I in tumor cells accelerates tumor immune evasion.
ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis.
Title: ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis.
ANGPTL2 aggravates LPS-induced septic cardiomyopathy via NLRP3-mediated inflammasome in a DUSP1-dependent pathway.
Title: ANGPTL2 aggravates LPS-induced septic cardiomyopathy via NLRP3-mediated inflammasome in a DUSP1-dependent pathway.
ANGPTL2 Deletion Attenuates Neuroinflammation and Cognitive Dysfunction Induced by Isoflurane in Aged Mice through Modulating MAPK Pathway.
Title: ANGPTL2 Deletion Attenuates Neuroinflammation and Cognitive Dysfunction Induced by Isoflurane in Aged Mice through Modulating MAPK Pathway.
Angiopoietin-like 2 is essential to aortic valve development in mice.
Title: Angiopoietin-like 2 is essential to aortic valve development in mice.
Tumor cell-derived ANGPTL2 promotes beta-catenin-driven intestinal tumorigenesis.
Title: Tumor cell-derived ANGPTL2 promotes β-catenin-driven intestinal tumorigenesis.
Efficient expansion of mouse hematopoietic stem cells ex vivo by membrane anchored Angptl2.
Title: Efficient expansion of mouse hematopoietic stem cells ex vivo by membrane anchored Angptl2.
Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches.
Title: Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches.
ANGPTL2 Promotes Inflammation via Integrin alpha5beta1 in Chondrocytes.
Title: ANGPTL2 Promotes Inflammation via Integrin α5β1 in Chondrocytes.
ANGPTL2-containing small extracellular vesicles from vascular endothelial cells accelerate leukemia progression.
Title: ANGPTL2-containing small extracellular vesicles from vascular endothelial cells accelerate leukemia progression.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI593246 (e-PCR)
- UniSTS:164157

AW260363 (e-PCR)
- UniSTS:178609

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: angiopoietin-related protein 2

Names: angiopoietin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011923.4 → NP_036053.2 angiopoietin-related protein 2 precursor

See identical proteins and their annotated locations for NP_036053.2

Status: PROVISIONAL

Source sequence(s)

AK155464

Consensus CDS

CCDS15940.1

UniProtKB/Swiss-Prot

Q8BM09, Q9R045

Related

ENSMUSP00000004208.6, ENSMUST00000004208.7

Conserved Domains (2) summary

smart00397
Location:156 → 206

t_SNARE; Helical region found in SNAREs

cd00087
Location:273 → 487

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

33105963..33137737

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498051.1 → XP_006498114.1 angiopoietin-related protein 2 isoform X1

See identical proteins and their annotated locations for XP_006498114.1

UniProtKB/Swiss-Prot

Q8BM09, Q9R045

Conserved Domains (2) summary

smart00397
Location:156 → 206

t_SNARE; Helical region found in SNAREs

cd00087
Location:273 → 487

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...