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    Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 [ Mus musculus (house mouse) ]

    Gene ID: 72400, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pinx1provided by MGI
    Official Full Name
    PIN2/TERF1 interacting, telomerase inhibitor 1provided by MGI
    Primary source
    MGI:MGI:1919650
    See related
    Ensembl:ENSMUSG00000021958 AllianceGenome:MGI:1919650
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LPTS; LPTS1; 67-11-3; 2210403I16Rik; 2610028A01Rik
    Summary
    Predicted to enable telomerase RNA binding activity and telomerase inhibitor activity. Predicted to be involved in several processes, including negative regulation of DNA biosynthetic process; positive regulation of protein localization to nucleolus; and protein localization to organelle. Predicted to act upstream of or within telomere maintenance via telomerase. Predicted to be located in several cellular components, including chromosomal region; nuclear lumen; and spindle. Is expressed in several structures, including brain; liver; mammary gland; sensory organ; and trigeminal ganglion. Orthologous to human PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 10.0), CNS E14 (RPKM 4.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 D1; 14 33.34 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (64097728..64157311)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (63860277..63919862)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene X-linked Kx blood group related 6 Neighboring gene predicted gene, 36218 Neighboring gene STARR-seq mESC enhancer starr_36932 Neighboring gene predicted gene, 41175 Neighboring gene RIKEN cDNA 4930578I06 gene Neighboring gene SRY (sex determining region Y)-box 7 Neighboring gene predicted gene, 36410

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PinX1t, a Novel PinX1 Transcript Variant, Positively Regulates Cardiogenesis of Embryonic Stem Cells. Chan HC, et al. J Am Heart Assoc, 2020 Mar 17. PMID 32157956, Free PMC Article
    2. [The cloning and expression of a novel mouse gene mLPTS and its subcellular localization]. Liao C, et al. Yi Chuan Xue Bao, 2002 Oct. PMID 12561469
    3. PinX1 Depletion Improves Liver Injury in a Mouse Model of Nonalcoholic Fatty Liver Disease via Increasing Telomerase Activity and Inhibiting Apoptosis. Huang E, et al. Cytogenet Genome Res, 2021. PMID 34657040
    4. The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. Zhou XZ, et al. J Clin Invest, 2011 Apr. PMID 21436583, Free PMC Article
    5. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Zhou XZ, et al. Cell, 2001 Nov 2. PMID 11701125

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PinX1 Depletion Improves Liver Injury in a Mouse Model of Nonalcoholic Fatty Liver Disease via Increasing Telomerase Activity and Inhibiting Apoptosis.
      Title: PinX1 Depletion Improves Liver Injury in a Mouse Model of Nonalcoholic Fatty Liver Disease via Increasing Telomerase Activity and Inhibiting Apoptosis.
    2. PinX1t, a Novel PinX1 Transcript Variant, Positively Regulates Cardiogenesis of Embryonic Stem Cells.
      Title: PinX1t, a Novel PinX1 Transcript Variant, Positively Regulates Cardiogenesis of Embryonic Stem Cells.
    3. PinX1 heterozygosity and PinX1 knockdown in mouse embryonic fibroblasts activated telomerase and led to concomitant telomerase-dependent chromosomal instability.
      Title: The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144540

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables telomerase RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables telomerase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomerase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    PIN2/TERF1-interacting telomerase inhibitor 1
    Names
    PIN2-interacting protein X1
    PIN2/TRF1-interacting protein
    TRF1-interacting protein 1
    liver-related putative tumor suppressor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028228.4 → NP_082504.1  PIN2/TERF1-interacting telomerase inhibitor 1

      See identical proteins and their annotated locations for NP_082504.1

      Status: VALIDATED

      Source sequence(s)
      AC118607, AC161764
      Consensus CDS
      CCDS27205.1
      UniProtKB/Swiss-Prot
      Q14BS4, Q3V450, Q8C6E5, Q91WZ9, Q9CZX5, Q9D0C2
      Related
      ENSMUSP00000022528.5, ENSMUST00000022528.6
      Conserved Domains (1) summary
      smart00443
      Location:24 → 69
      G_patch; glycine rich nucleic binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      64097728..64157311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519595.5 → XP_006519658.1  PIN2/TERF1-interacting telomerase inhibitor 1 isoform X1

      Conserved Domains (1) summary
      smart00443
      Location:24 → 69
      G_patch; glycine rich nucleic binding domain

    2. XM_030248045.2 → XP_030103905.1  PIN2/TERF1-interacting telomerase inhibitor 1 isoform X2

    3. XM_036158856.1 → XP_036014749.1  PIN2/TERF1-interacting telomerase inhibitor 1 isoform X3

    RNA

    1. XR_003950903.2 RNA Sequence

    2. XR_004938457.1 RNA Sequence

    3. XR_383213.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZX5.2 GenPept UniProtKB/Swiss-Prot:Q9CZX5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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