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    Stat5a signal transducer and activator of transcription 5A [ Mus musculus (house mouse) ]

    Gene ID: 20850, updated on 5-Sep-2021

    Summary

    Official Symbol
    Stat5aprovided by MGI
    Official Full Name
    signal transducer and activator of transcription 5Aprovided by MGI
    Primary source
    MGI:MGI:103036
    See related
    Ensembl:ENSMUSG00000004043
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    STA; STAT5; AA959963
    Expression
    Broad expression in thymus adult (RPKM 40.3), mammary gland adult (RPKM 29.6) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Stat5a in Genome Data Viewer
    Location:
    11 D; 11 63.77 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100750177..100775995)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100859351..100885169)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (100720665..100746483)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene GH3 domain containing Neighboring gene signal transducer and activator of transcription 5B Neighboring gene signal transducer and activator of transcription 3 Neighboring gene predicted gene, 46295 Neighboring gene caveolae associated 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within Peyer's patch development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within T cell differentiation in thymus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within T cell homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within development of secondary female sexual characteristics IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within development of secondary male sexual characteristics IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within development of secondary male sexual characteristics IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epithelial cell differentiation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within female pregnancy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within lactation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lipid storage IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within luteinization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland epithelium development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mammary gland involution ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within natural killer cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of erythrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of mast cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of B cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of activated T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of activated T cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gamma-delta T cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-2 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of lymphocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mast cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mast cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within prostate gland epithelium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within reelin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of steroid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within response to peptide hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within taurine metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    signal transducer and activator of transcription 5A
    Names
    mammary gland factor STAT5A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164062.1NP_001157534.1  signal transducer and activator of transcription 5A isoform 2

      See identical proteins and their annotated locations for NP_001157534.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), also known as delta E18, lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA718536, AK134012, BY277646, EU249543
      Consensus CDS
      CCDS48933.1
      UniProtKB/TrEMBL
      B2C3G8, Q3UZ79
      Related
      ENSMUSP00000102980.3, ENSMUST00000107357.4
      Conserved Domains (4) summary
      cd10421
      Location:573708
      SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
      pfam01017
      Location:141330
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:332582
      STAT_bind; STAT protein, DNA binding domain
      pfam02865
      Location:2124
      STAT_int; STAT protein, protein interaction domain
    2. NM_001362680.1NP_001349609.1  signal transducer and activator of transcription 5A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591466, BY478099
      Consensus CDS
      CCDS25439.1
      Related
      ENSMUSP00000102979.2, ENSMUST00000107356.8
      Conserved Domains (4) summary
      cd10421
      Location:573712
      SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
      cd16855
      Location:139330
      STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      cd16849
      Location:332489
      STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      pfam02865
      Location:4124
      STAT_int; STAT protein, protein interaction domain
    3. NM_011488.3NP_035618.1  signal transducer and activator of transcription 5A isoform 1

      See identical proteins and their annotated locations for NP_035618.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      AA718536, AK134012, AY299491, BY277646
      Consensus CDS
      CCDS25439.1
      UniProtKB/Swiss-Prot
      P42230
      UniProtKB/TrEMBL
      Q3UZ79, Q9JIA0
      Related
      ENSMUSP00000004145.8, ENSMUST00000004145.14
      Conserved Domains (4) summary
      cd10421
      Location:573712
      SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
      cd16855
      Location:139330
      STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      cd16849
      Location:332489
      STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      pfam02865
      Location:4124
      STAT_int; STAT protein, protein interaction domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100750177..100775995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532721.3XP_006532784.1  signal transducer and activator of transcription 5A isoform X1

      See identical proteins and their annotated locations for XP_006532784.1

      UniProtKB/Swiss-Prot
      P42230
      UniProtKB/TrEMBL
      Q9JIA0
      Conserved Domains (4) summary
      cd10421
      Location:573712
      SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
      cd16855
      Location:139330
      STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      cd16849
      Location:332489
      STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      pfam02865
      Location:4124
      STAT_int; STAT protein, protein interaction domain
    2. XM_017314402.3XP_017169891.1  signal transducer and activator of transcription 5A isoform X1

      UniProtKB/Swiss-Prot
      P42230
      UniProtKB/TrEMBL
      Q9JIA0
      Conserved Domains (4) summary
      cd10421
      Location:573712
      SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
      cd16855
      Location:139330
      STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      cd16849
      Location:332489
      STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      pfam02865
      Location:4124
      STAT_int; STAT protein, protein interaction domain
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