U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Trim26 tripartite motif-containing 26 [ Mus musculus (house mouse) ]

    Gene ID: 22670, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Trim26provided by MGI
    Official Full Name
    tripartite motif-containing 26provided by MGI
    Primary source
    MGI:MGI:1337056
    See related
    Ensembl:ENSMUSG00000024457 AllianceGenome:MGI:1337056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp173; Zfp1736
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of viral entry into host cell; and positive regulation of DNA-binding transcription factor activity. Predicted to act upstream of or within immune system process. Located in cytoplasm. Is expressed in genitourinary system. Orthologous to human TRIM26 (tripartite motif containing 26). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 19.3), spleen adult (RPKM 16.9) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Trim26 in Genome Data Viewer
    Location:
    17 B1; 17 19.16 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37148016..37170290)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36837123..36859398)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, M region locus 10.5 Neighboring gene histocompatibility 2, M region locus 10.6 Neighboring gene STARR-positive B cell enhancer ABC_E612 Neighboring gene predicted gene, 25973 Neighboring gene tripartite motif-containing 15 Neighboring gene tripartite motif-containing 10

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Transforming Growth Factor β-Induced Proliferative Arrest Mediated by TRIM26-Dependent TAF7 Degradation and Its Antagonism by MYC. Nakagawa T, et al. Mol Cell Biol, 2018 Mar 1. PMID 29203640, Free PMC Article
    2. TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3. Wang P, et al. PLoS Pathog, 2015 Mar. PMID 25763818, Free PMC Article
    3. Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination. Zhao W, et al. Cell, 2013 Feb 28. PMID 23452852, Free PMC Article
    4. BAC/YAC contigs from the H2-M region of mouse Chr 17 define gene order as Znf173-Tctex5-mog-D17Tu42-M3-M2. Yoshino M, et al. Immunogenetics, 1998 Apr. PMID 9510555
    5. The tripartite motif family identifies cell compartments. Reymond A, et al. EMBO J, 2001 May 1. PMID 11331580, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM26 alleviates fatal immunopathology by regulating inflammatory neutrophil infiltration during Candida infection.
      Title: TRIM26 alleviates fatal immunopathology by regulating inflammatory neutrophil infiltration during Candida infection.
    2. Sustained exposure of cells to TGF-beta resulted in recovery from proliferative arrest in association with amplification of the Myc proto-oncogene, with MYC inhibiting TRIM26 induction by TGF-beta.
      Title: Transforming Growth Factor β-Induced Proliferative Arrest Mediated by TRIM26-Dependent TAF7 Degradation and Its Antagonism by MYC.
    3. Our findings delineate a novel mechanism for the termination of IRF3 activation in nucleus through TRIM26-mediated IRF3 ubiquitination and degradation.
      Title: TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in suppression of viral release by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tripartite motif-containing protein 26
    Names
    tripartite motif protein 26
    tripartite motif protein TRIM26
    zinc finger protein 173
    NP_001020770.2
    NP_001273655.1
    NP_001273656.1
    XP_006524276.1
    XP_006524277.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025599.3 → NP_001020770.2  tripartite motif-containing protein 26

      See identical proteins and their annotated locations for NP_001020770.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has an alternate splice site in the 5' UTR, compared to variant 3. Variants 1, 3 and 4 encode the same protein.
      Source sequence(s)
      BC037110, BQ176978, CF168373
      Consensus CDS
      CCDS37613.1
      UniProtKB/Swiss-Prot
      B8JJ55, Q8C9E9, Q8JZT7, Q99PN2, Q99PN3
      UniProtKB/TrEMBL
      Q3UFX3
      Related
      ENSMUSP00000060103.8, ENSMUST00000053434.15
      Conserved Domains (3) summary
      cd15826
      Location:320 → 544
      SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
      cd16598
      Location:13 → 57
      RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
      cd19765
      Location:100 → 138
      Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

    2. NM_001286726.1 → NP_001273655.1  tripartite motif-containing protein 26

      See identical proteins and their annotated locations for NP_001273655.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 3 and 4 encode the same protein.
      Source sequence(s)
      AK042252, BC037110, BQ176978, CF168373
      Consensus CDS
      CCDS37613.1
      UniProtKB/Swiss-Prot
      B8JJ55, Q8C9E9, Q8JZT7, Q99PN2, Q99PN3
      UniProtKB/TrEMBL
      Q3UFX3
      Conserved Domains (3) summary
      cd15826
      Location:320 → 544
      SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
      cd16598
      Location:13 → 57
      RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
      cd19765
      Location:100 → 138
      Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

    3. NM_001286727.1 → NP_001273656.1  tripartite motif-containing protein 26

      See identical proteins and their annotated locations for NP_001273656.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate splice junction in the 5' UTR, compared to variant 3. Variants 1, 3 and 4 encode the same protein.
      Source sequence(s)
      AK148247, BC037110, BQ176978, CF168373
      Consensus CDS
      CCDS37613.1
      UniProtKB/Swiss-Prot
      B8JJ55, Q8C9E9, Q8JZT7, Q99PN2, Q99PN3
      UniProtKB/TrEMBL
      Q3UFX3
      Related
      ENSMUSP00000114896.2, ENSMUST00000130367.8
      Conserved Domains (3) summary
      cd15826
      Location:320 → 544
      SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
      cd16598
      Location:13 → 57
      RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
      cd19765
      Location:100 → 138
      Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      37148016..37170290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524214.4 → XP_006524277.1  tripartite motif-containing protein 26 isoform X2

      See identical proteins and their annotated locations for XP_006524277.1

      UniProtKB/TrEMBL
      J3QN94, Q3UFX3
      Conserved Domains (3) summary
      cd15826
      Location:314 → 538
      SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
      cd16598
      Location:13 → 57
      RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
      cd19765
      Location:100 → 138
      Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

    2. XM_006524213.4 → XP_006524276.1  tripartite motif-containing protein 26 isoform X1

      See identical proteins and their annotated locations for XP_006524276.1

      UniProtKB/Swiss-Prot
      B8JJ55, Q8C9E9, Q8JZT7, Q99PN2, Q99PN3
      UniProtKB/TrEMBL
      Q3UFX3
      Conserved Domains (3) summary
      cd15826
      Location:320 → 544
      SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
      cd16598
      Location:13 → 57
      RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins
      cd19765
      Location:100 → 138
      Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_030698.4: Suppressed sequence

      Description
      NM_030698.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PN3.3 GenPept UniProtKB/Swiss-Prot:Q99PN3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous