Il20 interleukin 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il20provided by MGI
Official Full Name: interleukin 20provided by MGI
Primary source: MGI:MGI:1890473
See related: Ensembl:ENSMUSG00000026416 AllianceGenome:MGI:1890473
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: If2d; Zcyto10
Summary: Enables cytokine activity; interleukin-20 receptor binding activity; and interleukin-22 receptor binding activity. Acts upstream of or within positive regulation of osteoclast differentiation. Located in extracellular space. Is expressed in Harderian gland; ductus deferens; epididymis; prostate gland; and skin. Human ortholog(s) of this gene implicated in psoriasis. Orthologous to human IL20 (interleukin 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 56.89 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (130834722..130839033, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (130906985..130911296, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling.
Title: IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling.
IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis.
Title: IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis.
IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis.
Title: IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis.
IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation.
Title: IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation.
our data suggest that IL-20 subfamily cytokines, particularly IL-20, IL-22, and IL-24, might provide therapeutic benefit for patients with Diabetic foot ulcers (DFU) .
Title: IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice.
The authors conclude that IL-20 affects bone formation and downregulates osteoblastogenesis by modulating sclerostin, osterix, RUNX2, and osteoprotegerin on osteoblasts.
Title: Anti-IL-20 monoclonal antibody promotes bone fracture healing through regulating IL-20-mediated osteoblastogenesis.
Data show that interleukin 20 (IL-20) is expressed in type 2 diabetic db/db islets and contributes to inflammation.
Title: Neutralizing Anti-IL20 Antibody Treatment Significantly Modulates Low Grade Inflammation without Affecting HbA1c in Type 2 Diabetic db/db Mice.
IL-20 is primarily up regulated in psoriatic skin at the post-transcriptional level.
Title: AMPK/HuR-Driven IL-20 Post-Transcriptional Regulation in Psoriatic Skin.
our results suggest that IL-20 plays pivotal roles in the tumor progression of breast cancer. IL-20 expression in breast cancer tissue is associated with a poor clinical outcome.
Title: Anti-IL-20 monoclonal antibody suppresses breast cancer progression and bone osteolysis in murine models.
novel effects of IL-20 on mesangial cells and its association with lupus nephritis.
Title: Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:490560

D1Mit345 (e-PCR), detects polymorphism
- UniSTS:128704

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables interleukin-20 receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-20 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables interleukin-22 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in hemopoiesis	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of receptor signaling pathway via JAK-STAT	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-20

Names: IL-20; cytokine Zcyto10; four alpha helix cytokine ZCYTO10; four helix bundle cytokine 10; interferon 2d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311091.1 → NP_001298020.1 interleukin-20 isoform 2

See identical proteins and their annotated locations for NP_001298020.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AF224267, BB064801

Consensus CDS

CCDS78673.1

UniProtKB/TrEMBL

Q2THG5

Related

ENSMUSP00000141088.2, ENSMUST00000188581.2

Conserved Domains (1) summary

cl02501
Location:58 → 151

IL10; Interleukin 10
NM_021380.2 → NP_067355.1 interleukin-20 isoform 1 precursor

See identical proteins and their annotated locations for NP_067355.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF224267, BB064801

Consensus CDS

CCDS15263.1

UniProtKB/Swiss-Prot

Q9JKV9

UniProtKB/TrEMBL

Q2NKI0

Related

ENSMUSP00000027673.5, ENSMUST00000027673.11

Conserved Domains (1) summary

cl02501
Location:39 → 173

IL10; Interleukin 10