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    Klrc3 killer cell lectin-like receptor subfamily C, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 58179, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Klrc3provided by MGI
    Official Full Name
    killer cell lectin-like receptor subfamily C, member 3provided by MGI
    Primary source
    MGI:MGI:1929720
    See related
    Ensembl:ENSMUSG00000033027 AllianceGenome:MGI:1929720
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Klrc2; Nkg2e
    Summary
    Predicted to enable MHC class I protein complex binding activity; MHC class Ib receptor activity; and protein antigen binding activity. Predicted to be involved in natural killer cell mediated immunity; positive regulation of natural killer cell degranulation; and stimulatory C-type lectin receptor signaling pathway. Located in external side of plasma membrane. Orthologous to several human genes including KLRC1 (killer cell lectin like receptor C1) and KLRC2 (killer cell lectin like receptor C2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Klrc3 in Genome Data Viewer
    Location:
    6 F3; 6 63.44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129613226..129620474, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129636263..129643511, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor, subfamily D, member 1 Neighboring gene killer cell lectin-like receptor subfamily K, member 1 Neighboring gene killer cell lectin-like receptor subfamily C, member 2 Neighboring gene killer cell lectin-like receptor subfamily C, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Development and function of CD94-deficient natural killer cells. Orr MT, et al. PLoS One, 2010 Dec 3. PMID 21151939, Free PMC Article
    2. Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing. Ferez M, et al. J Exp Med, 2021 May 3. PMID 33765134, Free PMC Article
    3. Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. Vance RE, et al. J Exp Med, 1999 Dec 20. PMID 10601355, Free PMC Article
    4. Structural basis for NKG2A/CD94 recognition of HLA-E. Kaiser BK, et al. Proc Natl Acad Sci U S A, 2008 May 6. PMID 18448674, Free PMC Article
    5. Bone marrow allograft rejection mediated by a novel murine NK receptor, NKG2I. Koike J, et al. J Exp Med, 2004 Jan 5. PMID 14707119, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of natural killer cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of natural killer cell activation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in stimulatory C-type lectin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    killer cell lectin-like receptor subfamily C, member 3
    Names
    killer cell lectin-like receptor subfamily C, member 2
    natural killer cell group 2E cell receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021378.1 → NP_067353.1  killer cell lectin-like receptor subfamily C, member 3

      See identical proteins and their annotated locations for NP_067353.1

      Status: PROVISIONAL

      Source sequence(s)
      AF195779
      Consensus CDS
      CCDS20591.1
      UniProtKB/TrEMBL
      L7N477, Q9QXN7
      Related
      ENSMUSP00000071147.6, ENSMUST00000071149.7
      Conserved Domains (2) summary
      cd03593
      Location:105 → 217
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      PHA03097
      Location:65 → 220
      PHA03097; C-type lectin-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      129613226..129620474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506430.2 → XP_006506493.1  killer cell lectin-like receptor subfamily C, member 3 isoform X1

      UniProtKB/TrEMBL
      A1L3Q6
      Conserved Domains (1) summary
      cd03593
      Location:130 → 242
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    Nucleotide Protein Strain
    Heading Accession and Version

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