Dgat2 diacylglycerol O-acyltransferase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dgat2provided by MGI
Official Full Name: diacylglycerol O-acyltransferase 2provided by MGI
Primary source: MGI:MGI:1915050
See related: Ensembl:ENSMUSG00000030747 AllianceGenome:MGI:1915050
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARAT; DGAT-2; 0610010B06Rik
Summary: Enables 2-acylglycerol O-acyltransferase activity; diacylglycerol O-acyltransferase activity; and protein homodimerization activity. Involved in several processes, including cellular response to oleic acid; diacylglycerol biosynthetic process; and lipid homeostasis. Acts upstream of or within triglyceride biosynthetic process. Located in endoplasmic reticulum; membrane; and perinuclear region of cytoplasm. Is integral component of endoplasmic reticulum membrane. Colocalizes with lipid droplet and mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Orthologous to human DGAT2 (diacylglycerol O-acyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 1253.2), mammary gland adult (RPKM 752.2) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 54.01 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (98802870..98831920, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (99153663..99182713, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER.
Title: DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER.
Role of Dgat2 in Glucose Uptake and Fatty Acid Metabolism in C2C12 Skeletal Myotubes.
Title: Role of Dgat2 in Glucose Uptake and Fatty Acid Metabolism in C2C12 Skeletal Myotubes.
Histone Demethylase KDM7A Contributes to the Development of Hepatic Steatosis by Targeting Diacylglycerol Acyltransferase 2.
Title: Histone Demethylase KDM7A Contributes to the Development of Hepatic Steatosis by Targeting Diacylglycerol Acyltransferase 2.
Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
Title: Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
CTRP12 inhibits triglyceride synthesis and export in hepatocytes by suppressing HNF-4alpha and DGAT2 expression.
Title: CTRP12 inhibits triglyceride synthesis and export in hepatocytes by suppressing HNF-4α and DGAT2 expression.
hepatic DGAT2 deficiency successfully reduces diet-induced hepatic steatosis.
Title: Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice.
DGAT2 expression and degradation during endoplasmic reticulum stress.
Title: ER stress mediated degradation of diacylglycerol acyltransferase impairs mitochondrial functions in TMCO1 deficient cells.
Hepatic VLDL secretion: DGAT1 determines particle size but not particle number, which can be supported entirely by DGAT2
Title: Hepatic VLDL secretion: DGAT1 determines particle size but not particle number, which can be supported entirely by DGAT2.
Study shows that inactivation of DGAT1 or DGAT2 in adult mouse heart results in a moderate suppression of triglycerides (TG) synthesis and turnover. Partial inhibition of DGAT activity increases cardiac fatty acid oxidation without affecting PPARalpha signaling, myocardial energetics or contractile function. Thus, the two DGAT isoforms in the heart have partially redundant function.
Title: The Role of Diacylglycerol Acyltransferase (DGAT) 1 and 2 in Cardiac Metabolism and Function.
Chronic inhibition of DGAT2 in a murine model of obesity led to correction of the lipid metabolism.
Title: DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Mit185 (e-PCR), detects polymorphism
- UniSTS:131075

Dgat2 (e-PCR), detects polymorphism
- UniSTS:461914

G42985 (e-PCR)
- UniSTS:94858

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2-acylglycerol O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diacylglycerol O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables diacylglycerol O-acyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables diacylglycerol O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables retinol O-fatty-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to oleic acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in diacylglycerol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in diacylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diacylglycerol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in diacylglycerol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fat pad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glycerol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid storage	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty-acyl-CoA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty-acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoacylglycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of plasma lipoprotein particle levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within triglyceride biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within triglyceride biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
colocalizes_with lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: diacylglycerol O-acyltransferase 2

Names: acyl-CoA retinol O-fatty-acyltransferase; diacylglycerol acyltransferase 2; diglyceride acyltransferase 2; retinol O-fatty-acyltransferase

NP_080660.1

EC 2.3.1.20

EC 2.3.1.76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.