Jarid2 jumonji and AT-rich interaction domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Jarid2provided by MGI
Official Full Name: jumonji and AT-rich interaction domain containing 2provided by MGI
Primary source: MGI:MGI:104813
See related: Ensembl:ENSMUSG00000038518 AllianceGenome:MGI:104813
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Jmj; jumonji
Summary: Enables several functions, including chromatin binding activity; ubiquitin binding activity; and ubiquitin modification-dependent histone binding activity. Involved in negative regulation of transcription by RNA polymerase II; regulation of histone methylation; and stem cell differentiation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; hematopoietic or lymphoid organ development; and regulation of gene expression. Located in nucleus. Part of ESC/E(Z) complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human JARID2 (jumonji and AT-rich interaction domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 13.8), CNS E14 (RPKM 9.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A5; 13 21.66 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (44881817..45075119)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (44730774..44921643)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-155 promotes compensatory lung growth by inhibiting JARID2 activation of CD34+ endothelial progenitor cells.
Title: MiR-155 promotes compensatory lung growth by inhibiting JARID2 activation of CD34+ endothelial progenitor cells.
Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1.
Title: Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1.
Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation.
Title: Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation.
Polycomb regulation is coupled to cell cycle transition in pluripotent stem cells.
Title: Polycomb regulation is coupled to cell cycle transition in pluripotent stem cells.
JARID2 and the PRC2 complex regulate skeletal muscle proliferation in a precise manner that involves the repression of cyclin D1, thus restraining proliferation and repressing RB1, which is required for mitotic exit and terminal differentiation
Title: JARID2 and the PRC2 complex regulate the cell cycle in skeletal muscle.
This study demonstrates that ablation of Jarid2 in cardiomyocytes results in dilated cardiomyopathy and suggest that Jarid2 plays important roles in cardiomyocyte maturation during neonatal stages.
Title: Myocardial-specific ablation of Jumonji and AT-rich interaction domain-containing 2 (Jarid2) leads to dilated cardiomyopathy in mice.
In this study, genetic mouse models and patient-derived xenografts demonstrated that JARID2 acts as a tumor suppressor in chronic myeloid disorders.
Title: JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells.
The deletion of Jarid2 by Nkx2.5-Cre mice (Jarid2(Nkx)) caused cardiac malformations including ventricular septal defects, thin myocardium, hypertrabeculation, and neonatal lethality. Jarid2(Nkx) mice exhibited elevated expression of neural genes, cardiac jelly, and other key factors including Isl1 and Bmp10 in the developing heart.
Title: Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development.
JARID2 regulates muscle differentiation by modulating Wnt signaling through direct repression of SFRP1.
Title: JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling.
These findings ascribe a critical function to Jarid2 and define a key mechanism that links PRC1 and PRC2 in the establishment of Polycomb domains.
Title: Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (3) 1 citation
Targeted (6) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126121 (e-PCR)
- UniSTS:162833

D13Mit179 (e-PCR), detects polymorphism
- UniSTS:126994

jmj (e-PCR), detects polymorphism
- UniSTS:143643

AU045941 (e-PCR)
- UniSTS:160292

C77215 (e-PCR)
- UniSTS:160293

C79931 (e-PCR)
- UniSTS:180524

RH126171 (e-PCR)
- UniSTS:162881

RH126766 (e-PCR)
- UniSTS:207439

Jarid2 (e-PCR), detects polymorphism
- UniSTS:507004

D31967 (e-PCR)
- UniSTS:124826

JARID2_3393 (e-PCR)
- UniSTS:462286

Jarid2 (e-PCR), detects polymorphism
- UniSTS:536529

D13Ertd787e (e-PCR), detects polymorphism
- UniSTS:167125

AU021389 (e-PCR)
- UniSTS:165867

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
NOT contributes_to histone H3K27 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to histone H3K27 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables histone demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables histone demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin-modified histone reader activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in facultative heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein localization to pericentric heterochromatin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within random inactivation of X chromosome	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spleen development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thymus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of histone methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein Jumonji

Names: jumonji, AT rich interactive domain 2; jumonji/ARID domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205043.2 → NP_001191972.1 protein Jumonji isoform 1

See identical proteins and their annotated locations for NP_001191972.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).

Source sequence(s)

AC166074, AC170597

Consensus CDS

CCDS36646.1

UniProtKB/Swiss-Prot

Q3TPU4, Q3UHS7, Q62315, Q99LD1

UniProtKB/TrEMBL

G3UZT8

Related

ENSMUSP00000134205.2, ENSMUST00000173246.8

Conserved Domains (4) summary

smart00545
Location:554 → 595

JmjN; Small domain found in the jumonji family of transcription factors

cd16870
Location:618 → 729

ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins

pfam02373
Location:914 → 1029

JmjC; JmjC domain, hydroxylase

pfam02928
Location:1137 → 1190

zf-C5HC2; C5HC2 zinc finger
NM_001205044.1 → NP_001191973.1 protein Jumonji isoform 1

See identical proteins and their annotated locations for NP_001191973.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).

Source sequence(s)

AC166074, AC170597

Consensus CDS

CCDS36646.1

UniProtKB/Swiss-Prot

Q3TPU4, Q3UHS7, Q62315, Q99LD1

UniProtKB/TrEMBL

G3UZT8

Related

ENSMUSP00000134675.2, ENSMUST00000173704.8

Conserved Domains (4) summary

smart00545
Location:554 → 595

JmjN; Small domain found in the jumonji family of transcription factors

cd16870
Location:618 → 729

ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins

pfam02373
Location:914 → 1029

JmjC; JmjC domain, hydroxylase

pfam02928
Location:1137 → 1190

zf-C5HC2; C5HC2 zinc finger
NM_001360281.1 → NP_001347210.1 protein Jumonji isoform 2

Status: VALIDATED

Source sequence(s)

AC166074, AC170597

UniProtKB/TrEMBL

Q1LZL9

Conserved Domains (5) summary

smart00545
Location:382 → 423

JmjN; Small domain found in the jumonji family of transcription factors

pfam02373
Location:742 → 857

JmjC; JmjC domain, hydroxylase

cd16870
Location:446 → 557

ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins

pfam02928
Location:965 → 1018

zf-C5HC2; C5HC2 zinc finger

pfam09422
Location:218 → 390

WTX; WTX protein
NM_021878.3 → NP_068678.1 protein Jumonji isoform 1

See identical proteins and their annotated locations for NP_068678.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).

Source sequence(s)

AC166074, AC170597, BC052444

Consensus CDS

CCDS36646.1

UniProtKB/Swiss-Prot

Q3TPU4, Q3UHS7, Q62315, Q99LD1

UniProtKB/TrEMBL

G3UZT8

Related

ENSMUSP00000037774.8, ENSMUST00000044608.14

Conserved Domains (4) summary

smart00545
Location:554 → 595

JmjN; Small domain found in the jumonji family of transcription factors

cd16870
Location:618 → 729

ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins

pfam02373
Location:914 → 1029

JmjC; JmjC domain, hydroxylase

pfam02928
Location:1137 → 1190

zf-C5HC2; C5HC2 zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

44881817..45075119

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157864.1 → XP_036013757.1 protein Jumonji isoform X1

UniProtKB/Swiss-Prot

Q3TPU4, Q3UHS7, Q62315, Q99LD1

UniProtKB/TrEMBL

G3UZT8

Conserved Domains (4) summary

smart00545
Location:554 → 595

JmjN; Small domain found in the jumonji family of transcription factors

cd16870
Location:618 → 729

ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins

pfam02373
Location:914 → 1029

JmjC; JmjC domain, hydroxylase

pfam02928
Location:1137 → 1190

zf-C5HC2; C5HC2 zinc finger
XM_036157863.1 → XP_036013756.1 protein Jumonji isoform X1

UniProtKB/Swiss-Prot

Q3TPU4, Q3UHS7, Q62315, Q99LD1

UniProtKB/TrEMBL

G3UZT8

Related

ENSMUSP00000134630.2, ENSMUST00000173906.3

Conserved Domains (4) summary

smart00545
Location:554 → 595

JmjN; Small domain found in the jumonji family of transcription factors

cd16870
Location:618 → 729

ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins

pfam02373
Location:914 → 1029

JmjC; JmjC domain, hydroxylase

pfam02928
Location:1137 → 1190

zf-C5HC2; C5HC2 zinc finger
XM_006516859.4 → XP_006516922.1 protein Jumonji isoform X3

See identical proteins and their annotated locations for XP_006516922.1

UniProtKB/TrEMBL

Q1LZL9

Conserved Domains (5) summary

smart00545
Location:382 → 423

JmjN; Small domain found in the jumonji family of transcription factors

pfam02373
Location:742 → 857

JmjC; JmjC domain, hydroxylase

cd16870
Location:446 → 557

ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins

pfam02928
Location:965 → 1018

zf-C5HC2; C5HC2 zinc finger

pfam09422
Location:218 → 390

WTX; WTX protein
XM_006516858.5 → XP_006516921.1 protein Jumonji isoform X2

See identical proteins and their annotated locations for XP_006516921.1

UniProtKB/TrEMBL

G3UZT8

Conserved Domains (5) summary

smart00545
Location:516 → 557

JmjN; Small domain found in the jumonji family of transcription factors

pfam02373
Location:876 → 991

JmjC; JmjC domain, hydroxylase

cd16870
Location:580 → 691

ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins

pfam02928
Location:1099 → 1152

zf-C5HC2; C5HC2 zinc finger

pfam09422
Location:352 → 524

WTX; WTX protein
XM_006516860.4 → XP_006516923.1 protein Jumonji isoform X3

See identical proteins and their annotated locations for XP_006516923.1

UniProtKB/TrEMBL

Q1LZL9

Conserved Domains (5) summary

smart00545
Location:382 → 423

JmjN; Small domain found in the jumonji family of transcription factors

pfam02373
Location:742 → 857

JmjC; JmjC domain, hydroxylase

cd16870
Location:446 → 557

ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins

pfam02928
Location:965 → 1018

zf-C5HC2; C5HC2 zinc finger

pfam09422
Location:218 → 390

WTX; WTX protein