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    Igfbp3 insulin-like growth factor binding protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 16009, updated on 29-Jun-2021

    Summary

    Official Symbol
    Igfbp3provided by MGI
    Official Full Name
    insulin-like growth factor binding protein 3provided by MGI
    Primary source
    MGI:MGI:96438
    See related
    Ensembl:ENSMUSG00000020427
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IGFBP; IGFBP-3; IGgfbp3; AI649005
    Expression
    Broad expression in kidney adult (RPKM 114.2), limb E14.5 (RPKM 82.6) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Igfbp3 in Genome Data Viewer
    Location:
    11 A1; 11 4.75 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (7156086..7165498, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (7206086..7215498, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (7106089..7113926, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled coil domain 201 Neighboring gene insulin-like growth factor binding protein 1 Neighboring gene predicted gene, 36565 Neighboring gene predicted gene, 36653

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fibronectin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fibronectin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin-like growth factor I binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables insulin-like growth factor I binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin-like growth factor II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables insulin-like growth factor II binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin-like growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine phosphatase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of testosterone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within osteoblast differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of apoptotic DNA fragmentation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of glucose metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within type B pancreatic cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    part_of insulin-like growth factor binary complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of insulin-like growth factor ternary complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in platelet alpha granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    insulin-like growth factor-binding protein 3
    Names
    IBP-3
    IGF-binding protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008343.2NP_032369.2  insulin-like growth factor-binding protein 3 precursor

      See identical proteins and their annotated locations for NP_032369.2

      Status: VALIDATED

      Source sequence(s)
      AK141690, AL607124, BP754524
      Consensus CDS
      CCDS24428.1
      UniProtKB/Swiss-Prot
      P47878
      UniProtKB/TrEMBL
      Q3UR87
      Related
      ENSMUSP00000020702.5, ENSMUST00000020702.11
      Conserved Domains (3) summary
      smart00121
      Location:39117
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:214286
      Thyroglobulin_1; Thyroglobulin type-1 repeat
      cl00349
      Location:137186
      S15_NS1_EPRS_RNA-bind; S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      7156086..7165498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243665.3XP_011241967.1  insulin-like growth factor-binding protein 3 isoform X1

      Conserved Domains (3) summary
      smart00121
      Location:2285
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:182254
      Thyroglobulin_1; Thyroglobulin type-1 repeat
      cl00349
      Location:105154
      S15_NS1_EPRS_RNA-bind; S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic ...
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