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    Scg5 secretogranin V [ Mus musculus (house mouse) ]

    Gene ID: 20394, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Scg5provided by MGI
    Official Full Name
    secretogranin Vprovided by MGI
    Primary source
    MGI:MGI:98289
    See related
    Ensembl:ENSMUSG00000023236 AllianceGenome:MGI:98289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    7B2; Sgne1; Sgne-1
    Summary
    Enables enzyme inhibitor activity. Involved in intracellular protein transport; peptide hormone processing; and regulation of hormone secretion. Is active in nucleus. Is expressed in several structures, including gut; lung; nervous system; and sensory organ. Used to study pituitary-dependent Cushing's disease. Orthologous to human SCG5 (secretogranin V). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 84.7), cerebellum adult (RPKM 75.9) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 E4; 2 57.45 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (113606708..113659423, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (113776313..113829091, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene gremlin 1, DAN family BMP antagonist Neighboring gene predicted gene, 46756 Neighboring gene STARR-positive B cell enhancer mm9_chr2:113664128-113664429 Neighboring gene Rho GTPase activating protein 11A Neighboring gene STARR-seq mESC enhancer starr_05402 Neighboring gene predicted gene, 30985

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. 7B2 chaperone knockout in APP model mice results in reduced plaque burden. Jarvela TS, et al. Sci Rep, 2018 Jun 28. PMID 29955078, Free PMC Article
    2. Differences of pancreatic expression of 7B2 between C57BL/6J and C3H/HeJ mice and genetic polymorphisms at its locus (Sgne1). Schmidt G, et al. Diabetes, 2006 Feb. PMID 16443780
    3. The lethal form of Cushing's in 7B2 null mice is caused by multiple metabolic and hormonal abnormalities. Sarac MS, et al. Endocrinology, 2002 Jun. PMID 12021197
    4. Intrapituitary adenoviral administration of 7B2 can extend life span and reverse endocrinological deficiencies in 7B2 null mice. Sarac MS, et al. Endocrinology, 2002 Jun. PMID 12021196
    5. Transposon-generated 'knock-out' and 'knock-in' gene-targeting constructs for use in mice. Westphal CH, et al. Curr Biol, 1997 Jul 1. PMID 9210379

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. brain 7B2 can impact Abeta disposition in a manner that facilitates plaque formation.
      Title: 7B2 chaperone knockout in APP model mice results in reduced plaque burden.
    2. Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein has a preferential effect on glucagon synthesis
      Title: Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein: preferential effect on glucagon synthesis.
    3. 7B2 possesses chaperone activity that blocks partially unfolded pro-PC2 forms from losing catalytic competence and then aggregating.
      Title: 7B2 prevents unfolding and aggregation of prohormone convertase 2.
    4. a role for Scg5 in the modulation of body weight
      Title: Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice.
    5. data indicate that null prohormone convertase 2 and 7B2 protein are not phenotypically equivalent in pituitary proopiomelanocortin (POMC) biosynthesis and granule content
      Title: Biosynthesis of proopiomelanocortin-derived peptides in prohormone convertase 2 and 7B2 null mice.
    6. Phenotypic differences between the 7B2 and PC2 nulls and play a life-or-death role in the ACTH hypersecretion syndrome present in both 129 nulls.
      Title: Strain-dependent influences on the hypothalamo-pituitary-adrenal axis profoundly affect the 7B2 and PC2 null phenotypes.
    7. 7B2 nulls exhibit a multisystem disorder of vital organs, most notably the liver, in which massive steatosis and necrosis are observed. Metabolic derangements in glucose metabolism result in glycogen and fat deposition in liver
      Title: The lethal form of Cushing's in 7B2 null mice is caused by multiple metabolic and hormonal abnormalities.
    8. 7B2 has a role in endoproteolytic processing in mouse brain
      Title: Proteolytic processing of chromogranins is modified in brains of transgenic mice.
    9. 7B2-related peptides modulate regulated secretion of ACTH in neuroendocrine cells.
      Title: ACTH secretion by mouse corticotroph AtT20 cells is negatively modulated by the intracellular level of 7B2.
    10. phosphorylation of 7B2 functionally inactivates this protein in a manner analogous to the phosphorylating inactivation of BiP, which impairs its ability to bind substrate
      Title: Neuroendocrine protein 7B2 can be inactivated by phosphorylation within the secretory pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptide hormone processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of hormone secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of hormone secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuroendocrine protein 7B2
    Names
    secretogranin-5
    secretory granule endocrine protein I
    secretory granule neuroendocrine protein 1, 7B2 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420937.1 → NP_001407866.1  neuroendocrine protein 7B2 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AL772405
      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51

    2. NM_001420938.1 → NP_001407867.1  neuroendocrine protein 7B2 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AL772405
      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51

    3. NM_001420939.1 → NP_001407868.1  neuroendocrine protein 7B2 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AL772405
      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51

    4. NM_001420942.1 → NP_001407871.1  neuroendocrine protein 7B2 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AL772405
      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51

    5. NM_001420943.1 → NP_001407872.1  neuroendocrine protein 7B2 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AL772405
      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51

    6. NM_001420944.1 → NP_001407873.1  neuroendocrine protein 7B2 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AL772405
      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51

    7. NM_001420945.1 → NP_001407874.1  neuroendocrine protein 7B2 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AL772405
      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51

    8. NM_001420946.1 → NP_001407875.1  neuroendocrine protein 7B2 isoform d precursor

      Status: VALIDATED

      Source sequence(s)
      AL772405

    9. NM_001420947.1 → NP_001407876.1  neuroendocrine protein 7B2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL772405

    10. NM_009162.4 → NP_033188.3  neuroendocrine protein 7B2 isoform c precursor

      See identical proteins and their annotated locations for NP_033188.3

      Status: VALIDATED

      Source sequence(s)
      AL772405
      Consensus CDS
      CCDS16561.1
      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
      Related
      ENSMUSP00000024005.8, ENSMUST00000024005.8
      Conserved Domains (1) summary
      pfam05281
      Location:24 → 199
      Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)

    RNA

    1. NR_185217.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772405

    2. NR_185218.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772405

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      113606708..113659423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159847.1 → XP_036015740.1  neuroendocrine protein 7B2 isoform X1

      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
      Conserved Domains (1) summary
      pfam05281
      Location:24 → 199
      Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)

    2. XM_036159851.1 → XP_036015744.1  neuroendocrine protein 7B2 isoform X1

      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
      Conserved Domains (1) summary
      pfam05281
      Location:24 → 199
      Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)

    3. XM_036159848.1 → XP_036015741.1  neuroendocrine protein 7B2 isoform X1

      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
      Conserved Domains (1) summary
      pfam05281
      Location:24 → 199
      Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)

    4. XM_036159849.1 → XP_036015742.1  neuroendocrine protein 7B2 isoform X1

      UniProtKB/Swiss-Prot
      P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
      UniProtKB/TrEMBL
      Q3TT51
      Conserved Domains (1) summary
      pfam05281
      Location:24 → 199
      Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12961.1 GenPept UniProtKB/Swiss-Prot:P12961

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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