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    Dok4 docking protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 114255, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dok4provided by MGI
    Official Full Name
    docking protein 4provided by MGI
    Primary source
    MGI:MGI:2148865
    See related
    Ensembl:ENSMUSG00000040631 AllianceGenome:MGI:2148865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Acts upstream of or within nervous system development; positive regulation of MAPK cascade; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; heart; retina; and spleen primordium. Orthologous to human DOK4 (docking protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in colon adult (RPKM 63.0), large intestine adult (RPKM 54.8) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dok4 in Genome Data Viewer
    Location:
    8 C5; 8 46.93 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95590456..95602940, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94863828..94876312, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene cytokine induced apoptosis inhibitor 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene coenzyme Q9 Neighboring gene STARR-positive B cell enhancer ABC_E10518 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide C Neighboring gene coiled-coil domain containing 102A Neighboring gene STARR-positive B cell enhancer mm9_chr8:97441323-97441623 Neighboring gene adhesion G protein-coupled receptor G5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pleckstrin homology and phosphotyrosine-binding domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells. Bedirian A, et al. J Biol Chem, 2004 Apr 30. PMID 14963042
    2. New insights into Dok-4 PTB domain structure and function. Hooker E, et al. Biochem Biophys Res Commun, 2012 Oct 12. PMID 22982678
    3. Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4. Hooker E, et al. Biochem J, 2017 Apr 19. PMID 28275114
    4. The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS. Tedeschi A, et al. Neuron, 2016 Oct 19. PMID 27720483
    5. Endocardiogenesis in embryoid bodies: novel markers identified by gene expression profiling. Narumiya H, et al. Biochem Biophys Res Commun, 2007 Jun 15. PMID 17462595

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dok-4 can target Elk-4 activity through multiple mechanisms, including binding of the transactivation domain, nuclear exclusion and protein destabilization.
      Title: Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4.
    2. the current study have explored in more detail the structure and function of the Dok-4 PTB domain.
      Title: New insights into Dok-4 PTB domain structure and function.
    3. Dok-4 is a constitutively membrane-localized adapter molecule that may function as an inhibitor of tyrosine kinase signaling in epithelial cells.
      Title: Pleckstrin homology and phosphotyrosine-binding domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within nervous system development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    docking protein 4
    Names
    downstream of tyrosine kinase 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053246.3 → NP_444476.1  docking protein 4

      See identical proteins and their annotated locations for NP_444476.1

      Status: VALIDATED

      Source sequence(s)
      AC129606
      Consensus CDS
      CCDS40443.1
      UniProtKB/Swiss-Prot
      Q3U0X3, Q99KE3
      Related
      ENSMUSP00000043554.8, ENSMUST00000046461.9
      Conserved Domains (2) summary
      cd13164
      Location:133 → 235
      PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
      cd14678
      Location:9 → 113
      PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      95590456..95602940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530579.5 → XP_006530642.1  docking protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006530642.1

      UniProtKB/Swiss-Prot
      Q3U0X3, Q99KE3
      Conserved Domains (2) summary
      cd13164
      Location:133 → 235
      PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
      cd14678
      Location:9 → 113
      PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins

    2. XM_036153721.1 → XP_036009614.1  docking protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q3U0X3, Q99KE3
      Related
      ENSMUSP00000148355.2, ENSMUST00000212810.2
      Conserved Domains (2) summary
      cd13164
      Location:133 → 235
      PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
      cd14678
      Location:9 → 113
      PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins

    3. XM_030243242.2 → XP_030099102.1  docking protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q3U0X3, Q99KE3
      Conserved Domains (2) summary
      cd13164
      Location:133 → 235
      PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
      cd14678
      Location:9 → 113
      PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KE3.1 GenPept UniProtKB/Swiss-Prot:Q99KE3

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