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    Traf1 TNF receptor-associated factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 22029, updated on 11-Jul-2021

    Summary

    Official Symbol
    Traf1provided by MGI
    Official Full Name
    TNF receptor-associated factor 1provided by MGI
    Primary source
    MGI:MGI:101836
    See related
    Ensembl:ENSMUSG00000026875
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4732496E14Rik
    Expression
    Biased expression in spleen adult (RPKM 9.8), thymus adult (RPKM 8.2) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Traf1 in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34831762..34851784, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34941750..34961812, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (34798778..34817292, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene PHD finger protein 19 Neighboring gene predicted gene, 24905 Neighboring gene predicted gene, 52552 Neighboring gene predicted gene, 46733 Neighboring gene mitochondrial import receptor subunit TOM7 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thioesterase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tumor necrosis factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables tumor necrosis factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of plasma membrane signaling receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    TNF receptor-associated factor 1
    NP_001313530.1
    NP_033447.2
    XP_011237352.1
    XP_011237353.1
    XP_011237354.1
    XP_011237355.1
    XP_011237356.1
    XP_036016379.1
    XP_036016380.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326601.1NP_001313530.1  TNF receptor-associated factor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK029135, AL929068, BY209774
      Consensus CDS
      CCDS15956.1
      UniProtKB/Swiss-Prot
      P39428
      Related
      ENSMUSP00000130759.2, ENSMUST00000172159.8
      Conserved Domains (3) summary
      cd03779
      Location:260406
      MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
      TIGR02168
      Location:126257
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16673
      Location:180237
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
    2. NM_009421.4NP_033447.2  TNF receptor-associated factor 1

      See identical proteins and their annotated locations for NP_033447.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK029135, AL929068
      Consensus CDS
      CCDS15956.1
      UniProtKB/Swiss-Prot
      P39428
      Related
      ENSMUSP00000108687.2, ENSMUST00000113064.8
      Conserved Domains (3) summary
      cd03779
      Location:260406
      MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
      TIGR02168
      Location:126257
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16673
      Location:180237
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      34831762..34851784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239053.4XP_011237355.1  TNF receptor-associated factor 1 isoform X1

      See identical proteins and their annotated locations for XP_011237355.1

      UniProtKB/Swiss-Prot
      P39428
      Conserved Domains (3) summary
      cd03779
      Location:260406
      MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
      TIGR02168
      Location:126257
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16673
      Location:180237
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
    2. XM_011239052.4XP_011237354.1  TNF receptor-associated factor 1 isoform X1

      See identical proteins and their annotated locations for XP_011237354.1

      UniProtKB/Swiss-Prot
      P39428
      Conserved Domains (3) summary
      cd03779
      Location:260406
      MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
      TIGR02168
      Location:126257
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16673
      Location:180237
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
    3. XM_011239050.4XP_011237352.1  TNF receptor-associated factor 1 isoform X1

      See identical proteins and their annotated locations for XP_011237352.1

      UniProtKB/Swiss-Prot
      P39428
      Conserved Domains (3) summary
      cd03779
      Location:260406
      MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
      TIGR02168
      Location:126257
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16673
      Location:180237
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
    4. XM_011239051.4XP_011237353.1  TNF receptor-associated factor 1 isoform X1

      See identical proteins and their annotated locations for XP_011237353.1

      UniProtKB/Swiss-Prot
      P39428
      Conserved Domains (3) summary
      cd03779
      Location:260406
      MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
      TIGR02168
      Location:126257
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16673
      Location:180237
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
    5. XM_011239054.4XP_011237356.1  TNF receptor-associated factor 1 isoform X1

      See identical proteins and their annotated locations for XP_011237356.1

      UniProtKB/Swiss-Prot
      P39428
      Related
      ENSMUSP00000028234.6, ENSMUST00000028234.12
      Conserved Domains (3) summary
      cd03779
      Location:260406
      MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
      TIGR02168
      Location:126257
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16673
      Location:180237
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
    6. XM_036160486.1XP_036016379.1  TNF receptor-associated factor 1 isoform X2

      Conserved Domains (2) summary
      cl02446
      Location:260287
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam16673
      Location:180237
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
    7. XM_036160487.1XP_036016380.1  TNF receptor-associated factor 1 isoform X3

      Conserved Domains (1) summary
      pfam16673
      Location:180228
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
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