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    Farsb phenylalanyl-tRNA synthetase, beta subunit [ Mus musculus (house mouse) ]

    Gene ID: 23874, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Farsbprovided by MGI
    Official Full Name
    phenylalanyl-tRNA synthetase, beta subunitprovided by MGI
    Primary source
    MGI:MGI:1346035
    See related
    Ensembl:ENSMUSG00000026245 AllianceGenome:MGI:1346035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Frsb; Farsa; Farsl; Farslb
    Summary
    Predicted to enable phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and protein heterotetramerization. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be part of phenylalanine-tRNA ligase complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human FARSB (phenylalanyl-tRNA synthetase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 23.6), liver E14 (RPKM 19.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Farsb in Genome Data Viewer
    Location:
    1 C4; 1 40.44 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (78394593..78465530, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (78417958..78488897, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate phosphatase 2 Neighboring gene predicted gene, 51634 Neighboring gene STARR-seq mESC enhancer starr_01426 Neighboring gene STARR-positive B cell enhancer ABC_E4327 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9179 Neighboring gene STARR-seq mESC enhancer starr_01427 Neighboring gene monoacylglycerol O-acyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E5774 Neighboring gene STARR-positive B cell enhancer ABC_E322 Neighboring gene predicted gene, 39665 Neighboring gene RIKEN cDNA 5730419F03 gene Neighboring gene STARR-seq mESC enhancer starr_01430 Neighboring gene STARR-seq mESC enhancer starr_01431 Neighboring gene predicted gene, 57683

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning of the cDNA encoding phenylalanyl tRNA synthetase regulatory alpha-subunit-like protein whose expression is down-regulated during differentiation. Zhou X, et al. Gene, 1999 Jun 11. PMID 10375616
    2. Identification and sequencing the juvenile spermatogonial depletion critical interval on mouse chromosome 1 reveals the presence of eight candidate genes. Boettger-Tong HL, et al. Biochem Biophys Res Commun, 2001 Nov 16. PMID 11700028
    3. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684
    4. Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. Zhou X, et al. J Cell Biol, 2015 Sep 14. PMID 26370502, Free PMC Article
    5. ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. Cozzolino F, et al. Hum Mol Genet, 2021 Jun 17. PMID 33601422

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to phenylalanine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phenylalanine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in phenylalanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylalanyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phenylalanine-tRNA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phenylalanine-tRNA ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phenylalanine--tRNA ligase beta subunit
    Names
    PheRS alpha
    phenylalanine tRNA synthetase alpha
    phenylalanine--tRNA ligase beta chain
    phenylalanine-tRNA synthetase-like, beta subunit
    phenylalanyl-tRNA synthetase beta chain
    NP_001265004.1
    NP_001408307.1
    NP_001408308.1
    NP_001408309.1
    NP_001408310.1
    NP_001408311.1
    NP_001408312.1
    NP_035941.2
    XP_036020538.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278075.2 → NP_001265004.1  phenylalanine--tRNA ligase beta subunit isoform 1

      See identical proteins and their annotated locations for NP_001265004.1

      Status: VALIDATED

      Source sequence(s)
      AC115932, AC158559
      Consensus CDS
      CCDS15084.1
      UniProtKB/Swiss-Prot
      Q9CWZ8, Q9WUA2
      UniProtKB/TrEMBL
      Q3TG12, Q8C644
      Related
      ENSMUSP00000129828.2, ENSMUST00000170217.8
      Conserved Domains (4) summary
      smart00873
      Location:118 → 279
      B3_4; B3/4 domain
      PLN02265
      Location:1 → 589
      PLN02265; probable phenylalanyl-tRNA synthetase beta chain
      cd00769
      Location:392 → 588
      PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...
      pfam03484
      Location:310 → 374
      B5; tRNA synthetase B5 domain

    2. NM_001421378.1 → NP_001408307.1  phenylalanine--tRNA ligase beta subunit isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115932, AC158559

    3. NM_001421379.1 → NP_001408308.1  phenylalanine--tRNA ligase beta subunit isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC115932, AC158559

    4. NM_001421380.1 → NP_001408309.1  phenylalanine--tRNA ligase beta subunit isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC115932, AC158559

    5. NM_001421381.1 → NP_001408310.1  phenylalanine--tRNA ligase beta subunit isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC115932, AC158559

    6. NM_001421382.1 → NP_001408311.1  phenylalanine--tRNA ligase beta subunit isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC115932, AC158559

    7. NM_001421383.1 → NP_001408312.1  phenylalanine--tRNA ligase beta subunit isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC115932, AC158559

    8. NM_011811.5 → NP_035941.2  phenylalanine--tRNA ligase beta subunit isoform 1

      See identical proteins and their annotated locations for NP_035941.2

      Status: VALIDATED

      Source sequence(s)
      AC115932, AC158559
      Consensus CDS
      CCDS15084.1
      UniProtKB/Swiss-Prot
      Q9CWZ8, Q9WUA2
      UniProtKB/TrEMBL
      Q3TG12, Q8C644
      Related
      ENSMUSP00000069508.8, ENSMUST00000068333.14
      Conserved Domains (4) summary
      smart00873
      Location:118 → 279
      B3_4; B3/4 domain
      PLN02265
      Location:1 → 589
      PLN02265; probable phenylalanyl-tRNA synthetase beta chain
      cd00769
      Location:392 → 588
      PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...
      pfam03484
      Location:310 → 374
      B5; tRNA synthetase B5 domain

    RNA

    1. NR_102757.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC115932, AC158559
      Related
      ENSMUST00000189529.7

    2. NR_102758.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC115932, AC158559

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      78394593..78465530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164645.1 → XP_036020538.1  phenylalanine--tRNA ligase beta subunit isoform X1

      UniProtKB/TrEMBL
      Q3TG12
      Conserved Domains (1) summary
      PLN02265
      Location:27 → 595
      PLN02265; probable phenylalanyl-tRNA synthetase beta chain

    RNA

    1. XR_865550.2 RNA Sequence

    2. XR_004942238.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUA2.2 GenPept UniProtKB/Swiss-Prot:Q9WUA2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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