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    Bambi BMP and activin membrane-bound inhibitor [ Mus musculus (house mouse) ]

    Gene ID: 68010, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Bambiprovided by MGI
    Official Full Name
    BMP and activin membrane-bound inhibitorprovided by MGI
    Primary source
    MGI:MGI:1915260
    See related
    Ensembl:ENSMUSG00000024232 AllianceGenome:MGI:1915260
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610003H06Rik
    Summary
    Predicted to enable frizzled binding activity. Predicted to be involved in several processes, including positive regulation of epithelial to mesenchymal transition; regulation of signal transduction; and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within negative regulation of BMP signaling pathway. Predicted to be located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human BAMBI (BMP and activin membrane bound inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 11.7), lung adult (RPKM 6.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 A1; 18 2.3 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (3507011..3516404)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (3507011..3516404)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene cullin 2 Neighboring gene STARR-seq mESC enhancer starr_43658 Neighboring gene profilin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43660 Neighboring gene STARR-positive B cell enhancer ABC_E10980 Neighboring gene STARR-seq mESC enhancer starr_43661 Neighboring gene STARR-seq mESC enhancer starr_43662 Neighboring gene STARR-seq mESC enhancer starr_43663 Neighboring gene STARR-seq mESC enhancer starr_43664 Neighboring gene STARR-seq mESC enhancer starr_43666 Neighboring gene STARR-seq mESC enhancer starr_43667 Neighboring gene predicted gene, 54028 Neighboring gene ribosomal protein L7A, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Therapeutic Effects of Anti-Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor Treatment in Psoriasis and Arthritis. Alvarez P, et al. Arthritis Rheumatol, 2020 Sep. PMID 32249544
    2. Leptin promotes epithelial-mesenchymal transition in benign prostatic hyperplasia through downregulation of BAMBI. Zhang B, et al. Exp Cell Res, 2020 Feb 1. PMID 31805276
    3. Defective fibrin deposition and thrombus stability in Bambi(-/-) mice are mediated by elevated anticoagulant function. Crawley JTB, et al. J Thromb Haemost, 2019 Nov. PMID 31351019, Free PMC Article
    4. BAMBI shuttling between cytosol and membrane is required for skeletal muscle development and regeneration. Yao X, et al. Biochem Biophys Res Commun, 2019 Jan 29. PMID 30580997
    5. BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork. Hernandez H, et al. Invest Ophthalmol Vis Sci, 2018 Apr 1. PMID 29801150, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epitranscriptional regulation of TGF-beta pseudoreceptor BAMBI by m6A/YTHDF2 drives extrinsic radioresistance.
      Title: Epitranscriptional regulation of TGF-β pseudoreceptor BAMBI by m6A/YTHDF2 drives extrinsic radioresistance.
    2. Therapeutic Effects of Anti-Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor Treatment in Psoriasis and Arthritis.
      Title: Therapeutic Effects of Anti-Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor Treatment in Psoriasis and Arthritis.
    3. Leptin promotes epithelial-mesenchymal transition in benign prostatic hyperplasia through downregulation of BAMBI.
      Title: Leptin promotes epithelial-mesenchymal transition in benign prostatic hyperplasia through downregulation of BAMBI.
    4. Defective fibrin deposition and thrombus stability in Bambi(-/-) mice are mediated by elevated anticoagulant function.
      Title: Defective fibrin deposition and thrombus stability in Bambi(-/-) mice are mediated by elevated anticoagulant function.
    5. Comparing with the cytosolic trapping in resting muscle, BAMBI protein is enriched on cellular membrane during the muscle growth and regeneration, suggesting that BAMBI-mediated a significant signaling pathway may be an essential part of muscle growth and regeneration.
      Title: BAMBI shuttling between cytosol and membrane is required for skeletal muscle development and regeneration.
    6. BAMBI is required for normal C2C12 differentiation, and that its role in myogenesis is mediated by the Wnt/beta-catenin pathway.
      Title: BAMBI Promotes C2C12 Myogenic Differentiation by Enhancing Wnt/β-Catenin Signaling.
    7. BAMBI modulates the effects of diabetes on glomerular permselectivity in association with altered ERK1/2 and Smad1/5 signaling.
      Title: BAMBI elimination enhances alternative TGF-β signaling and glomerular dysfunction in diabetic mice.
    8. these results provide strong evidence for an important role of endothelium rather than platelet BAMBI as a positive regulator of both thrombus formation and stability.
      Title: Vessel wall BAMBI contributes to hemostasis and thrombus stability.
    9. we provide in vitro and in vivo evidence that BAMBI contributes to endothelial and vascular homeostasis
      Title: BAMBI regulates angiogenesis and endothelial homeostasis through modulation of alternative TGFβ signaling.
    10. suggest that BAMBI is involved in negative feedback loops that restrain the TGF-beta remodeling signals to protect the pressure-overloaded myocardium from uncontrolled extracellular matrix deposition in humans and mice
      Title: BAMBI (BMP and activin membrane-bound inhibitor) protects the murine heart from pressure-overload biomechanical stress by restraining TGF-β signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables frizzled binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BMP and activin membrane-bound inhibitor homolog
    Names
    BMP and activin membrane-bound inhibitor, homolog
    putative transmembrane protein NMA

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026505.2 → NP_080781.1  BMP and activin membrane-bound inhibitor homolog precursor

      See identical proteins and their annotated locations for NP_080781.1

      Status: PROVISIONAL

      Source sequence(s)
      AC140240
      Consensus CDS
      CCDS29034.1
      UniProtKB/Swiss-Prot
      Q3TP85, Q91XS6, Q9D0L6
      UniProtKB/TrEMBL
      A0A2C9NTD7
      Related
      ENSMUSP00000025075.2, ENSMUST00000025075.3
      Conserved Domains (1) summary
      pfam06211
      Location:4 → 111
      BAMBI; BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      3507011..3516404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250585.1 → XP_030106445.1  BMP and activin membrane-bound inhibitor homolog isoform X1

      UniProtKB/Swiss-Prot
      Q3TP85, Q91XS6, Q9D0L6
      UniProtKB/TrEMBL
      A0A2C9NTD7
      Conserved Domains (1) summary
      pfam06211
      Location:4 → 111
      BAMBI; BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0L6.1 GenPept UniProtKB/Swiss-Prot:Q9D0L6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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