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    Aurkb aurora kinase B [ Mus musculus (house mouse) ]

    Gene ID: 20877, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Aurkbprovided by MGI
    Official Full Name
    aurora kinase Bprovided by MGI
    Primary source
    MGI:MGI:107168
    See related
    Ensembl:ENSMUSG00000020897 AllianceGenome:MGI:107168
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aik2; Aim1; Ark2; AurB; IPL1; Stk5; AIM-1; AIRK2; STK-1; Stk12
    Summary
    This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 2 and 7. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in thymus adult (RPKM 36.3), liver E14.5 (RPKM 33.6) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B3; 11 42.32 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68936477..68942490)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69045624..69051664)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3961 Neighboring gene STARR-positive B cell enhancer ABC_E2357 Neighboring gene nuclear encoded tRNA glycine 6 (anticodon TCC) Neighboring gene nuclear encoded tRNA trytophan 7 (anticodon CCA) Neighboring gene STARR-positive B cell enhancer ABC_E3962 Neighboring gene STARR-positive B cell enhancer ABC_E5237 Neighboring gene BLOC-1 related complex subunit 6 Neighboring gene STARR-positive B cell enhancer ABC_E7002 Neighboring gene nuclear encoded tRNA isoleucine 4 (anticodon AAT)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An analog-sensitive allele of Aurora kinase B is lethal in mouse. Vazquez BN, et al. MicroPubl Biol, 2021. PMID 34841221, Free PMC Article
    2. Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B. Blengini CS, et al. Aging Cell, 2021 Nov. PMID 34704342, Free PMC Article
    3. Salivary glands require Aurora Kinase B for regeneration after transient innate immune-mediated injury. Shaalan A, et al. Sci Rep, 2019 Aug 5. PMID 31383943, Free PMC Article
    4. Aurora B prevents aneuploidy via MAD2 during the first mitotic cleavage in oxidatively damaged embryos. Li J, et al. Cell Prolif, 2019 Sep. PMID 31264311, Free PMC Article
    5. Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia. Alferez DG, et al. Int J Oncol, 2012 Oct. PMID 22858681

    See all (140) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aurora kinase B disruption suppresses pathological retinal angiogenesis by affecting cell cycle progression.
      Title: Aurora kinase B disruption suppresses pathological retinal angiogenesis by affecting cell cycle progression.
    2. Effect of Aurora kinase B on polyploidy and decidualization in mouse uterus.
      Title: Effect of Aurora kinase B on polyploidy and decidualization in mouse uterus.
    3. Haspin participates in AURKB recruitment to centromeres and contributes to chromosome congression in male mouse meiosis.
      Title: Haspin participates in AURKB recruitment to centromeres and contributes to chromosome congression in male mouse meiosis.
    4. CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells.
      Title: CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells.
    5. Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B.
      Title: Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B.
    6. Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes.
      Title: Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes.
    7. Adhesion-growth factor crosstalk regulates AURKB activation and ERK signalling in re-adherent fibroblasts.
      Title: Adhesion-growth factor crosstalk regulates AURKB activation and ERK signalling in re-adherent fibroblasts.
    8. High-throughput kinase inhibitor screening reveals roles for Aurora and Nuak kinases in neurite initiation and dendritic branching.
      Title: High-throughput kinase inhibitor screening reveals roles for Aurora and Nuak kinases in neurite initiation and dendritic branching.
    9. A functional genetic screen identifies aurora kinase b as an essential regulator of Sox9-positive mouse embryonic lung progenitor cells.
      Title: A functional genetic screen identifies aurora kinase b as an essential regulator of Sox9-positive mouse embryonic lung progenitor cells.
    10. Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
      Title: Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (10)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell cycle G2/M phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cleavage furrow formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic spindle midzone assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle midzone assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of B cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cGAS/STING signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic sister chromatid separation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromocenter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromosome passenger complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chromosome passenger complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle pole centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    aurora kinase B
    Names
    ARK-2
    aurora 1
    aurora B
    aurora- and IPL1-like midbody-associated protein 1
    aurora-related kinase 2
    aurora/IPL1-related kinase 2
    serine/threonine kinase 12
    serine/threonine kinase 5
    serine/threonine-protein kinase 12
    serine/threonine-protein kinase 5
    serine/threonine-protein kinase aurora-B
    NP_001412359.1
    NP_001412360.1
    NP_001412361.1
    NP_001412362.1
    NP_035626.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425430.1 → NP_001412359.1  aurora kinase B isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL645902

    2. NM_001425431.1 → NP_001412360.1  aurora kinase B isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL645902

    3. NM_001425432.1 → NP_001412361.1  aurora kinase B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL645902

    4. NM_001425433.1 → NP_001412362.1  aurora kinase B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL645902

    5. NM_011496.3 → NP_035626.1  aurora kinase B isoform 1

      See identical proteins and their annotated locations for NP_035626.1

      Status: REVIEWED

      Source sequence(s)
      AL645902
      Consensus CDS
      CCDS24877.1
      UniProtKB/Swiss-Prot
      O70126, Q61882, Q8C6C1
      Related
      ENSMUSP00000021277.6, ENSMUST00000021277.6
      Conserved Domains (2) summary
      smart00220
      Location:82 → 332
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:77 → 344
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      68936477..68942490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70126.2 GenPept UniProtKB/Swiss-Prot:O70126

    Gene LinkOut

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