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    Dctn2 dynactin 2 [ Mus musculus (house mouse) ]

    Gene ID: 69654, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Dctn2provided by MGI
    Official Full Name
    dynactin 2provided by MGI
    Primary source
    MGI:MGI:107733
    See related
    Ensembl:ENSMUSG00000025410 AllianceGenome:MGI:107733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p50; RBP50; DCTN-50; GMP23-48K; 2310042E05Rik; C130077D06Rik
    Summary
    Predicted to enable identical protein binding activity; protein kinase binding activity; and spectrin binding activity. Acts upstream of or within melanosome transport. Located in growth cone. Is expressed in several structures, including adipose tissue; alimentary system; early conceptus; genitourinary system; and nervous system. Orthologous to human DCTN2 (dynactin subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 150.2), adrenal adult (RPKM 99.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dctn2 in Genome Data Viewer
    Location:
    10 D3; 10 74.5 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127102131..127117828)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127266262..127281959)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F420014N23 gene Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, gamma Neighboring gene STARR-seq mESC enhancer starr_28215 Neighboring gene kinesin family member 5A Neighboring gene STARR-positive B cell enhancer ABC_E9810 Neighboring gene predicted gene, 40800 Neighboring gene STARR-positive B cell enhancer ABC_E10652 Neighboring gene STARR-positive B cell enhancer ABC_E1410 Neighboring gene STARR-positive B cell enhancer ABC_E6939 Neighboring gene methyl-CpG binding domain protein 6 Neighboring gene DNA-damage inducible transcript 3 Neighboring gene methionine-tRNA synthetase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:126748829-126749012 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential roles of kinesin and dynein in translocation of neurofilaments into axonal neurites. Lee S, et al. J Cell Sci, 2011 Apr 1. PMID 21363889
    2. Dynamitin affects cell-surface expression of voltage-gated sodium channel Nav1.5. Chatin B, et al. Biochem J, 2014 Nov 1. PMID 25088759
    3. Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes. Xu M, et al. Biochim Biophys Acta, 2013 Dec. PMID 24095928, Free PMC Article
    4. Dynactin is essential for growth cone advance. Abe TK, et al. Biochem Biophys Res Commun, 2008 Aug 1. PMID 18477476
    5. Interaction of Cep135 with a p50 dynactin subunit in mammalian centrosomes. Uetake Y, et al. Cell Motil Cytoskeleton, 2004 May. PMID 14983524

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within melanosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynactin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dynactin subunit 2
    Names
    50 kDa dynein-associated polypeptide
    dynactin complex 50 kDa subunit
    growth cone membrane protein 23-48K
    p50 dynamitin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190453.1 → NP_001177382.1  dynactin subunit 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC144852
      Conserved Domains (1) summary
      pfam04912
      Location:16 → 402
      Dynamitin; Dynamitin

    2. NM_001190454.1 → NP_001177383.1  dynactin subunit 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC144852
      Conserved Domains (1) summary
      pfam04912
      Location:16 → 405
      Dynamitin; Dynamitin

    3. NM_027151.2 → NP_081427.1  dynactin subunit 2 isoform 3

      See identical proteins and their annotated locations for NP_081427.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC144852, AK144464
      Consensus CDS
      CCDS24234.1
      UniProtKB/Swiss-Prot
      Q99KJ8
      UniProtKB/TrEMBL
      Q3TPZ5
      Related
      ENSMUSP00000026479.10, ENSMUST00000026479.11
      Conserved Domains (1) summary
      pfam04912
      Location:16 → 400
      Dynamitin; Dynamitin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127102131..127117828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514055.4 → XP_006514118.1  dynactin subunit 2 isoform X1

      Conserved Domains (1) summary
      pfam04912
      Location:16 → 401
      Dynamitin

    2. XM_036155985.1 → XP_036011878.1  dynactin subunit 2 isoform X2

      Conserved Domains (1) summary
      pfam04912
      Location:2 → 313
      Dynamitin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KJ8.3 GenPept UniProtKB/Swiss-Prot:Q99KJ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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