Cplx3 complexin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cplx3provided by MGI
Official Full Name: complexin 3provided by MGI
Primary source: MGI:MGI:2384571
See related: Ensembl:ENSMUSG00000039714 AllianceGenome:MGI:2384571
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ERGL; CpxIII; Lamn1l; Lman1l; ERGIC-53L
Summary: Enables SNARE binding activity and neurotransmitter transmembrane transporter activity. Involved in insulin secretion; regulation of synaptic vesicle fusion to presynaptic active zone membrane; and synaptic vesicle exocytosis. Acts upstream of or within regulation of neurotransmitter secretion. Located in cytosol; photoreceptor ribbon synapse; and plasma membrane. Is anchored component of presynaptic active zone membrane and anchored component of synaptic vesicle membrane. Is expressed in cerebral cortex and cortical layer V. Orthologous to human CPLX3 (complexin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 6.6) and frontal lobe adult (RPKM 2.8) See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 31.11 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (57507275..57513564, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (57599992..57606281, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The SNARE regulator Complexin3 is a target of the cone circadian clock.
Title: The SNARE regulator Complexin3 is a target of the cone circadian clock.
Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix.
Title: Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix.
This study links Cplx3 expression with synapse and circuit function in a specific retinal pathway and reveals a role for asynchronous release in circuit gain control.
Title: Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses.
The findings of this study reveal a suppressing action of Cplx3/4 on tonic neurotransmitter release, a facilitating action on evoked release, and a regulatory role of Cplx3/4 in the adaptation-dependent availability of synaptic vesicles at mouse photoreceptor ribbon synapses.
Title: Functional Roles of Complexin 3 and Complexin 4 at Mouse Photoreceptor Ribbon Synapses.
This study demonistrated that Cplx3-positive cells are generated during the 2-day peak of subplate neurogenesis (E11.5-E12.5). survive preferentially after the first postnatal week compared with other subplate neurons.
Title: Molecular diversity of early-born subplate neurons.
The lack of Cplx 3 and Cplx 4 differentially impacts the ON and OFF pathways in the retina is corroborated by localization studies of Cplx 3 and Cplx 4 in the retina.
Title: The absence of Complexin 3 and Complexin 4 differentially impacts the ON and OFF pathways in mouse retina.
Results show that complexin 3 and complexin 4 are essential regulators of transmitter release at retinal ribbon synapses.
Title: Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4.
The novel CPXs III and IV may contribute to the unique release efficacy of retinal sensory neurons.(cOMPLEXIN III, MOUSE)
Title: Structurally and functionally unique complexins at retinal ribbon synapses.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IDA Inferred from Direct Assay more info	PubMed
enables neurotransmitter transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables syntaxin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within exocytosis	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurotransmitter secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of neurotransmitter secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
NOT located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in photoreceptor ribbon synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in photoreceptor ribbon synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in presynaptic active zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in synaptic vesicle membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: complexin-3

Names: CPX III; complexin III; lectin, mannose-binding, 1 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.