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    H2-Q10 histocompatibility 2, Q region locus 10 [ Mus musculus (house mouse) ]

    Gene ID: 15007, updated on 23-Jun-2021

    Summary

    Official Symbol
    H2-Q10provided by MGI
    Official Full Name
    histocompatibility 2, Q region locus 10provided by MGI
    Primary source
    MGI:MGI:95929
    See related
    Ensembl:ENSMUSG00000067235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Q10; Qa1; Qa10; H2-K1; H-2Q10
    Expression
    Biased expression in liver adult (RPKM 1268.9), liver E18 (RPKM 262.7) and 3 other tissues See more
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    Genomic context

    See H2-Q10 in Genome Data Viewer
    Location:
    17 B1; 17 18.68 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35780986..35785460)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35470089..35474563)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (35607034..35611508)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, Q region locus 9 Neighboring gene predicted gene, 53263 Neighboring gene Pou5f1 5' regulatory region Neighboring gene predicted gene, 32362 Neighboring gene POU domain, class 5, transcription factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables CD8 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables T cell receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables TAP1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables TAP2 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-2-microglobulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables natural killer cell lectin-like receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptide antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MHC class I protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MHC class Ib protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cis-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of lumenal side of endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in phagocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    H-2 class I histocompatibility antigen, Q10 alpha chain
    Names
    MHC class I transplantation antigen
    MHC class II antigen K

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010391.4NP_034521.1  H-2 class I histocompatibility antigen, Q10 alpha chain precursor

      See identical proteins and their annotated locations for NP_034521.1

      Status: VALIDATED

      Source sequence(s)
      CU467494
      Consensus CDS
      CCDS37599.1
      UniProtKB/Swiss-Prot
      P01898
      Related
      ENSMUSP00000066419.7, ENSMUST00000068291.7
      Conserved Domains (2) summary
      cd07698
      Location:207299
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:25203
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35780986..35785460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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