Rgs3 regulator of G-protein signaling 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rgs3provided by MGI
Official Full Name: regulator of G-protein signaling 3provided by MGI
Primary source: MGI:MGI:1354734
See related: Ensembl:ENSMUSG00000059810 AllianceGenome:MGI:1354734
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C2pa; RGS3S; PDZ-RGS3; C2PA-RGS3; 4930506N09Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; lung; and nervous system. Orthologous to human RGS3 (regulator of G protein signaling 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 8.2), ovary adult (RPKM 7.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 33.19 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (62478079..62621256)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (62559835..62703019)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RGS3 may provide protection against pathological changes of adventitial fibroblasts and the development of atherosclerosis by inhibiting TGF-beta1/Smad signaling.
Title: RGS3 inhibits TGF-β1/Smad signalling in adventitial fibroblasts.
Results reveal an essential role of PDZ-RGS3 in maintaining the balance between self-renewal and differentiation of neural progenitor cells and provide genetic evidence linking PDZ-RGS3 to ephrin-B reverse signaling.
Title: Essential role of PDZ-RGS3 in the maintenance of neural progenitor cells.
C2PA is expressed in the cell nucleus and induces heat shock response element (HSE)-dependent gene transcription
Title: C2PA is a nuclear protein implicated in the heat shock response.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE098515 (e-PCR)
- UniSTS:245265

D5Uwm20 (e-PCR)
- UniSTS:239973

Rgs3 (e-PCR), detects polymorphism
- UniSTS:256893

Rgs3 (e-PCR), detects polymorphism
- UniSTS:256894

Rgs3 (e-PCR), detects polymorphism
- UniSTS:256895

Rgs3 (e-PCR), detects polymorphism
- UniSTS:256896

Rgs3 (e-PCR), detects polymorphism
- UniSTS:256897

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: regulator of G-protein signaling 3

Names: C2 membrane binding, PDZ protein/protein interaction, ATP/GTP binding domains

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081650.2 → NP_001075119.1 regulator of G-protein signaling 3 isoform 3

See identical proteins and their annotated locations for NP_001075119.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks several exons and includes an alternate 3' terminal exon, compared to variant 2. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 2.

Source sequence(s)

AK028445, BB653029, BB739116

Consensus CDS

CCDS38776.1

UniProtKB/Swiss-Prot

Q9DC04

Related

ENSMUSP00000103047.2, ENSMUST00000107424.2

Conserved Domains (2) summary

COG0265
Location:38 → 93

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:17 → 91

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001310706.1 → NP_001297635.1 regulator of G-protein signaling 3 isoform 4

See identical proteins and their annotated locations for NP_001297635.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in its 5' UTR and lacks multiple exons in the 5' coding region. These differences cause translation initiation at a downstream start codon compared to variant 2. It encodes isoform 4, which has a significantly shorter N-terminus, compared to isoform 2.

Source sequence(s)

AK004648, AL672272, BE686796, CF738041

Consensus CDS

CCDS80110.1

UniProtKB/Swiss-Prot

Q9DC04

Related

ENSMUSP00000103043.2, ENSMUST00000107420.8

Conserved Domains (2) summary

cd08713
Location:444 → 557

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

PHA03307
Location:3 → 226

PHA03307; transcriptional regulator ICP4; Provisional
NM_019492.3 → NP_062365.2 regulator of G-protein signaling 3 isoform 1

See identical proteins and their annotated locations for NP_062365.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' and 3' exon structure compared to variant 2. It encodes isoform 1 which is shorter and has distinct N- and C-termini, compared to isoform 2.

Source sequence(s)

AK015722, AK028445, AL672272, BB739116

Consensus CDS

CCDS18246.1

UniProtKB/TrEMBL

Z4YJQ4

Related

ENSMUSP00000065447.8, ENSMUST00000065870.14

Conserved Domains (2) summary

cd08685
Location:35 → 154

C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family

cd00992
Location:195 → 268

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_134257.3 → NP_599018.3 regulator of G-protein signaling 3 isoform 2

See identical proteins and their annotated locations for NP_599018.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes the longest isoform (2).

Source sequence(s)

AF319519, AF350047, AK004648, BE686796

Consensus CDS

CCDS51202.1

UniProtKB/Swiss-Prot

Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9DC04, Q9JL22, Q9JL23, Q9QXA2

Related

ENSMUSP00000081569.5, ENSMUST00000084521.11

Conserved Domains (5) summary

cd08713
Location:842 → 955

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

COG0265
Location:38 → 93

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:17 → 91

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15231
Location:428 → 572

VCX_VCY; Variable charge X/Y family

pfam15265
Location:438 → 592

FAM196; FAM196 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

62478079..62621256

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538057.4 → XP_006538120.1 regulator of G-protein signaling 3 isoform X1

Conserved Domains (4) summary

cd08685
Location:35 → 154

C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family

cd08713
Location:1019 → 1132

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

PHA03307
Location:578 → 801

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:195 → 268

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_011250065.4 → XP_011248367.1 regulator of G-protein signaling 3 isoform X6

Conserved Domains (2) summary

cd08685
Location:35 → 154

C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family

cd00992
Location:195 → 268

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_036164227.1 → XP_036020120.1 regulator of G-protein signaling 3 isoform X5

UniProtKB/TrEMBL

Z4YJQ4

Conserved Domains (2) summary

cd08685
Location:35 → 154

C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family

cd00992
Location:195 → 268

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_030253652.2 → XP_030109512.1 regulator of G-protein signaling 3 isoform X9

UniProtKB/TrEMBL

I7HPB2

Related

ENSMUSP00000095639.4, ENSMUST00000098031.10

Conserved Domains (2) summary

cd08685
Location:27 → 146

C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family

cd00992
Location:187 → 260

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006538058.5 → XP_006538121.1 regulator of G-protein signaling 3 isoform X2

Conserved Domains (4) summary

cd08685
Location:27 → 146

C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family

cd08713
Location:1011 → 1124

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

PHA03307
Location:570 → 793

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:187 → 260

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006538060.3 → XP_006538123.1 regulator of G-protein signaling 3 isoform X3

Conserved Domains (4) summary

cd08713
Location:961 → 1074

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

PHA03307
Location:520 → 743

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:137 → 210

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl14603
Location:1 → 96

C2; C2 domain
XM_036164226.1 → XP_036020119.1 regulator of G-protein signaling 3 isoform X4

Conserved Domains (3) summary

cd08713
Location:844 → 957

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

PHA03307
Location:403 → 626

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:20 → 93

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006538068.5 → XP_006538131.1 regulator of G-protein signaling 3 isoform X10

See identical proteins and their annotated locations for XP_006538131.1

UniProtKB/Swiss-Prot

Q9DC04

Conserved Domains (2) summary

cd08713
Location:444 → 557

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

PHA03307
Location:3 → 226

PHA03307; transcriptional regulator ICP4; Provisional
XM_006538070.4 → XP_006538133.1 regulator of G-protein signaling 3 isoform X10

See identical proteins and their annotated locations for XP_006538133.1

UniProtKB/Swiss-Prot

Q9DC04

Conserved Domains (2) summary

cd08713
Location:444 → 557

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

PHA03307
Location:3 → 226

PHA03307; transcriptional regulator ICP4; Provisional
XM_006538069.3 → XP_006538132.1 regulator of G-protein signaling 3 isoform X10

See identical proteins and their annotated locations for XP_006538132.1

UniProtKB/Swiss-Prot

Q9DC04

Conserved Domains (2) summary

cd08713
Location:444 → 557

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

PHA03307
Location:3 → 226

PHA03307; transcriptional regulator ICP4; Provisional
XM_006538067.4 → XP_006538130.2 regulator of G-protein signaling 3 isoform X7

Conserved Domains (2) summary

cd08713
Location:534 → 647

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

PHA03307
Location:93 → 316

PHA03307; transcriptional regulator ICP4; Provisional
XM_036164228.1 → XP_036020121.1 regulator of G-protein signaling 3 isoform X8

Conserved Domains (2) summary

cd08713
Location:486 → 599

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

PHA03307
Location:45 → 268

PHA03307; transcriptional regulator ICP4; Provisional
XM_017320308.3 → XP_017175797.1 regulator of G-protein signaling 3 isoform X11

UniProtKB/TrEMBL

Q542M0

Related

ENSMUSP00000159172.2, ENSMUST00000125369.8

Conserved Domains (1) summary

cd08713
Location:68 → 181

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
XM_006538072.4 → XP_006538135.1 regulator of G-protein signaling 3 isoform X12

See identical proteins and their annotated locations for XP_006538135.1

UniProtKB/TrEMBL

Q3TAS0

Conserved Domains (1) summary

cd08713
Location:44 → 157

RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein