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    Fcamr Fc receptor, IgA, IgM, high affinity [ Mus musculus (house mouse) ]

    Gene ID: 64435, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Fcamrprovided by MGI
    Official Full Name
    Fc receptor, IgA, IgM, high affinityprovided by MGI
    Primary source
    MGI:MGI:1927803
    See related
    Ensembl:ENSMUSG00000026415 AllianceGenome:MGI:1927803
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables IgA binding activity; IgM binding activity; and transmembrane signaling receptor activity. Predicted to act upstream of or within immune response. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in brain; cerebellum; and spinal cord. Orthologous to human FCAMR (Fc fragment of IgA and IgM receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 2.6), kidney adult (RPKM 1.8) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 E4; 1 56.89 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130712444..130753641)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130784706..130825903)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AA986860 Neighboring gene predicted gene 28857 Neighboring gene predicted gene 28856 Neighboring gene STARR-seq mESC enhancer starr_02205 Neighboring gene predicted gene 15848 Neighboring gene polymeric immunoglobulin receptor Neighboring gene STARR-positive B cell enhancer ABC_E9184 Neighboring gene STARR-positive B cell enhancer ABC_E9478 Neighboring gene Fc fragment of IgM receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fcµ Receptor Promotes the Survival and Activation of Marginal Zone B Cells and Protects Mice against Bacterial Sepsis. Liu J, et al. Front Immunol, 2018. PMID 29459869, Free PMC Article
    2. Involvement of Fcα/μ Receptor in IgM Anti-Platelet, but Not Anti-Red Blood Cell Autoantibody Pathogenicity in Mice. Legrain S, et al. J Immunol, 2015 Nov 1. PMID 26385523
    3. Increased serum IgA in Fcα/μR-deficient mice on the (129 x C57BL/6) F1 genetic background. Kurita N, et al. Mol Immunol, 2015 Feb. PMID 25282043
    4. Molecular characterization of the dimer formation of Fcα/μ receptor (CD351). Takagaki K, et al. Mol Immunol, 2013 Nov. PMID 23665380
    5. Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice. Honda S, et al. Proc Natl Acad Sci U S A, 2009 Jul 7. PMID 19549827, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results reveal a critical role for FcmuR in the survival and activation of marginal zone B cells and in protection against acute bacterial infection.
      Title: Fcµ Receptor Promotes the Survival and Activation of Marginal Zone B Cells and Protects Mice against Bacterial Sepsis.
    2. Toll-like receptor 4 (TLR4) requires physical and functional association with Fcalpha-mu protein (Fcalpha/muR) for its oligomer formation and interleukin-6 (IL-6) production from marginal zone (MZ) B cells.
      Title: Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling.
    3. Serum IgA production against gut-oriented antigens is negatively regulated by Fcalpha/muR on follicular dendritic cells in the F1 mice.
      Title: Increased serum IgA in Fcα/μR-deficient mice on the (129 x C57BL/6) F1 genetic background.
    4. These results suggest that Fcalpha/muR enhances, rather than suppresses, autoantibody production.
      Title: Involvement of Fcα/μR (CD351) in autoantibody production.
    5. Data suggest that Fcalpha/muR does not form homodimers, but forms heterodimers with an as-yet-unknown molecule with a molecular weight of 60-70 kDa.
      Title: Molecular characterization of the dimer formation of Fcα/μ receptor (CD351).
    6. A significant portion of the effector function of IgM, especially with regard to the enhancement of humoral immune responses and suppression of autoimmunity, is mediated by FcmuR.
      Title: Critical role of the IgM Fc receptor in IgM homeostasis, B-cell survival, and humoral immune responses.
    7. Mice deficient in Fc alpha/muR have enhanced germinal center formation and affinity maturation and memory induction of IgG3(+) B cells after immunization with T-independent antigens.[Fc alpha/muR]
      Title: Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice.
    8. expressed in oligodendrocytes, their precursor cells, and myelin
      Title: Expression of Fc receptor for immunoglobulin M in oligodendrocytes and myelin of mouse central nervous system.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC129330, MGC129331

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables IgA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables IgM binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
    Names
    Fc IgA/IgM receptor
    Fca/m receptor
    fc alpha/mu receptor
    mFcamR

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170632.1 → NP_001164103.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC139231, FJ011703
      Consensus CDS
      CCDS48353.1
      UniProtKB/Swiss-Prot
      Q2TB54
      Related
      ENSMUSP00000108096.3, ENSMUST00000112477.9
      Conserved Domains (2) summary
      cd05716
      Location:145 → 245
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:143 → 246
      IG_like; Immunoglobulin like

    2. NM_144960.2 → NP_659209.2  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_659209.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AB048834, BC110549, BC110550
      Consensus CDS
      CCDS15259.1
      UniProtKB/Swiss-Prot
      Q2TB54, Q2TB55, Q920L8, Q9EQT7
      Related
      ENSMUSP00000027670.4, ENSMUST00000027670.4
      Conserved Domains (1) summary
      cd05716
      Location:89 → 189
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      130712444..130753641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529787.5 → XP_006529850.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X2

      See identical proteins and their annotated locations for XP_006529850.1

      UniProtKB/Swiss-Prot
      Q2TB54, Q2TB55, Q920L8, Q9EQT7
      Conserved Domains (1) summary
      cd05716
      Location:89 → 189
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

    2. XM_017321925.3 → XP_017177414.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X2

      UniProtKB/Swiss-Prot
      Q2TB54, Q2TB55, Q920L8, Q9EQT7
      Conserved Domains (1) summary
      cd05716
      Location:89 → 189
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

    3. XM_017321923.3 → XP_017177412.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

      Conserved Domains (1) summary
      cd05716
      Location:139 → 239
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

    4. XM_017321921.2 → XP_017177410.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

      Conserved Domains (1) summary
      cd05716
      Location:139 → 239
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

    5. XM_017321922.2 → XP_017177411.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

      Conserved Domains (1) summary
      cd05716
      Location:139 → 239
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

    6. XM_017321924.2 → XP_017177413.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

      Conserved Domains (1) summary
      cd05716
      Location:139 → 239
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2TB54.2 GenPept UniProtKB/Swiss-Prot:Q2TB54

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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