Ifi27l2a interferon, alpha-inducible protein 27 like 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifi27l2aprovided by MGI
Official Full Name: interferon, alpha-inducible protein 27 like 2Aprovided by MGI
Primary source: MGI:MGI:1924183
See related: Ensembl:ENSMUSG00000079017 AllianceGenome:MGI:1924183
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ifi27; Isg12; Isg12(b1); 2310061N23Rik
Summary: Acts upstream of or within aging and response to virus. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrion. Is expressed in embryo. Orthologous to several human genes including IFI27L2 (interferon alpha inducible protein 27 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 553.4), subcutaneous fat pad adult (RPKM 344.9) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 E; 12 52.93 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (103400132..103409939, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (103433873..103443680, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Collectively, these findings suggest that Ifi27l2a has an antiviral phenotype in subsets of cells and that at least some interferon-stimulated genes have specific inhibitory functions in restricted tissues in West Nile virus infection.
Title: The Interferon-Stimulated Gene Ifi27l2a Restricts West Nile Virus Infection and Pathogenesis in a Cell-Type- and Region-Specific Manner.
up-regulation of Ifi27l2a in infected lungs is mainly due to the infiltration of macrophages and lymphocytes. Most surprisingly, deletion of Ifi27l2a in mouse knock-out lines did not result in increased susceptibility to infections
Title: The interferon-induced gene Ifi27l2a is active in lung macrophages and lymphocytes after influenza A infection but deletion of Ifi27l2a in mice does not increase susceptibility to infection.
modulator of innate immune responses in sepsis models
Title: ISG12 is a critical modulator of innate immune responses in murine models of sepsis.
Identify a feedback loop activated by interferons via interferon stimulated gene 12 that inhibits the vasculoprotective functions of NR4A1 nuclear receptors.
Title: The interferon stimulated gene 12 inactivates vasculoprotective functions of NR4A nuclear receptors.
Mitochondrial-localized ISG12b1 protein inhibits adipocyte differentiation and mitochondrial biogenesis and function.
Title: Interferon-stimulated gene ISG12b1 inhibits adipogenic differentiation and mitochondrial biogenesis in 3T3-L1 cells.
ISG12b is an additional candidate for a adipocytokine induced to express in adipose tissue by interferon
Title: Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue.
induced by Sindbis virus encephalitis to greater levels in brains of weanling mice than neonatal mice and significantly delayed death in the neonatal mice (interferon- inducible protective protein, ISG12).
Title: Age-dependent resistance to lethal alphavirus encephalitis in mice: analysis of gene expression in the central nervous system and identification of a novel interferon-inducible protective gene, mouse ISG12.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

General gene information

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Markers

PMC343271P1 (e-PCR)
- UniSTS:273187

PMC343271P2 (e-PCR)
- UniSTS:273188

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to virus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interferon alpha-inducible protein 27-like protein 2A

Names: interferon stimulated gene 12(b1); interferon-stimulated gene 12 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001281830.1 → NP_001268759.1 interferon alpha-inducible protein 27-like protein 2A isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon and contains an alternate 3' exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154347, AK040279

Conserved Domains (1) summary

pfam06140
Location:12 → 67

Ifi-6-16; Interferon-induced 6-16 family
NM_029803.3 → NP_084079.1 interferon alpha-inducible protein 27-like protein 2A isoform 1 precursor

See identical proteins and their annotated locations for NP_084079.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).

Source sequence(s)

AC154347, AK160503

Consensus CDS

CCDS49153.1

UniProtKB/Swiss-Prot

Q8R412

Related

ENSMUSP00000054698.9, ENSMUST00000055071.9

Conserved Domains (1) summary

pfam06140
Location:12 → 76

Ifi-6-16; Interferon-induced 6-16 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

103400132..103409939 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157657.1 → XP_036013550.1 interferon alpha-inducible protein 27-like protein 2A isoform X1

Conserved Domains (1) summary

pfam06140
Location:3 → 66

Ifi-6-16; Interferon-induced 6-16 family