U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Zc3hc1 zinc finger, C3HC type 1 [ Mus musculus (house mouse) ]

    Gene ID: 232679, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Zc3hc1provided by MGI
    Official Full Name
    zinc finger, C3HC type 1provided by MGI
    Primary source
    MGI:MGI:1916023
    See related
    Ensembl:ENSMUSG00000039130 AllianceGenome:MGI:1916023
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nipa; HSPC216; 1110054L24Rik
    Summary
    Predicted to enable protein kinase binding activity. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in nucleus. Orthologous to human ZC3HC1 (zinc finger C3HC-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.9), CNS E18 (RPKM 10.5) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Zc3hc1 in Genome Data Viewer
    Location:
    6 A3.3; 6 12.52 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30366383..30391019, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30366384..30391049, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2H Neighboring gene STARR-seq mESC enhancer starr_15462 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30250507-30250717 Neighboring gene RIKEN cDNA 1700095J07 gene Neighboring gene STARR-positive B cell enhancer ABC_E4817 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30290290-30290473 Neighboring gene STARR-seq mESC enhancer starr_15465 Neighboring gene STARR-positive B cell enhancer mm9_chr6:30307653-30307954 Neighboring gene STARR-positive B cell enhancer ABC_E6420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30351601-30351833 Neighboring gene kelch domain containing 10 Neighboring gene RIKEN cDNA 1700012C14 gene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure. Kreutmair S, et al. J Clin Invest, 2020 Jun 1. PMID 32338640, Free PMC Article
    2. Targeted inactivation of nuclear interaction partner of ALK disrupts meiotic prophase. Illert AL, et al. Development, 2012 Jul. PMID 22696294, Free PMC Article
    3. Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M. Illert AL, et al. J Biol Chem, 2012 Nov 2. PMID 22955283, Free PMC Article
    4. Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA). Ouyang T, et al. J Biol Chem, 2003 Aug 8. PMID 12748172
    5. APC/C(Cdh1)-mediated degradation of the F-box protein NIPA is regulated by its association with Skp1. Klitzing Cv, et al. PLoS One, 2011. PMID 22205987, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure.
      Title: Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure.
    2. Data show that cell cycle-dependent phosphorylation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA)is mediated by extracellular signal-regulated kinase 2 (ERK2).
      Title: Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M.
    3. Results reveal a novel role for NIPA in meiosis.
      Title: Targeted inactivation of nuclear interaction partner of ALK disrupts meiotic prophase.
    4. phosphorylated NIPA is degraded in late mitosis in an APC/C(Cdh1)-dependent manner
      Title: APC/C(Cdh1)-mediated degradation of the F-box protein NIPA is regulated by its association with Skp1.
    5. NIPA has an antiapoptotic role in NPM-ALK-mediated signaling events
      Title: Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    zinc finger C3HC-type protein 1
    Names
    nuclear interacting partner of anaplastic lymphoma kinase (Alk)
    nuclear-interacting partner of ALK

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311086.1 → NP_001298015.1  zinc finger C3HC-type protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001298015.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK151694, BC050141, BY235523
      Consensus CDS
      CCDS80508.1
      UniProtKB/Swiss-Prot
      Q3TJE6, Q80YV2, Q80Z11, Q8BTW5, Q8CI56, Q8R3U7
      UniProtKB/TrEMBL
      Q3TI64
      Related
      ENSMUSP00000079627.8, ENSMUST00000080812.14
      Conserved Domains (2) summary
      pfam07967
      Location:73 → 201
      zf-C3HC; C3HC zinc finger-like
      pfam08600
      Location:248 → 337
      Rsm1; Rsm1-like

    2. NM_172735.3 → NP_766323.1  zinc finger C3HC-type protein 1 isoform 2

      See identical proteins and their annotated locations for NP_766323.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC155848, AC160148
      Consensus CDS
      CCDS19970.1
      UniProtKB/TrEMBL
      Q3TI64
      Related
      ENSMUSP00000100057.4, ENSMUST00000102992.10
      Conserved Domains (3) summary
      PTZ00449
      Location:302 → 476
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam07967
      Location:73 → 201
      zf-C3HC; C3HC zinc finger-like
      pfam08600
      Location:248 → 337
      Rsm1; Rsm1-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      30366383..30391019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321571.3 → XP_017177060.1  zinc finger C3HC-type protein 1 isoform X1

      UniProtKB/TrEMBL
      Q3TI64
      Conserved Domains (3) summary
      PTZ00449
      Location:302 → 476
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam07967
      Location:73 → 201
      zf-C3HC; C3HC zinc finger-like
      pfam08600
      Location:248 → 337
      Rsm1; Rsm1-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80YV2.1 GenPept UniProtKB/Swiss-Prot:Q80YV2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous