Ighm immunoglobulin heavy constant mu [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ighmprovided by MGI
Official Full Name: immunoglobulin heavy constant muprovided by MGI
Primary source: MGI:MGI:96448
See related: Ensembl:ENSMUSG00000076617 IMGT/GENE-DB:IGHM; AllianceGenome:MGI:96448
Gene type: other
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Igm; muH; Igh6; Igh-6; Igh-M
Summary: Enables several functions, including antigen binding activity; identical protein binding activity; and immunoglobulin receptor binding activity. Acts upstream of or within several processes, including early endosome to late endosome transport; immunoglobulin mediated immune response; and positive regulation of B cell proliferation. Located in external side of plasma membrane; extracellular space; and perinuclear region of cytoplasm. Part of B cell receptor complex and immunoglobulin complex, circulating. Is expressed in several structures, including brain; hemolymphoid system; and liver. Used to study non-Hodgkin lymphoma and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in agammaglobulinemia. Orthologous to human IGHM (immunoglobulin heavy constant mu). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 12 F1; 12 62.1 cM

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (113382446..113386350, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (113418826..113422730, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The circulating immunoglobulins negatively impact on the parasite clearance in the liver of Leishmania donovani-infected mice via dampening reactive oxygen species activity.
Title: The circulating immunoglobulins negatively impact on the parasite clearance in the liver of Leishmania donovani-infected mice via dampening ROS activity.
IgM-expressing plasma cells can sense antigen and acquire competence for cytokine production upon antigenic challenge.
Title: Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge.
this study shows that in muMT-/- mice, induction of memory "precursor" effector CD4+ T cells is strongly impaired resulting in a deficiency of the memory TH1 response
Title: Antigen presentation by B cells guides programing of memory CD4(+) T-cell responses to a TLR4-agonist containing vaccine in mice.
Full-length Emu region does not influence variable heavy (VH) segment usage but ensures efficient Igmu-chain expression required for strong signaling through pre-B cells and newly formed B cell receptors, thus participating in B cell inflow and fate.
Title: The Eμ enhancer region influences H chain expression and B cell fate without impacting IgVH repertoire and immune response in vivo.
Radiation combined injury-induced alterations of corticosterone, CRP, C3, IgM, and PGE2 cause homeostatic imbalance and may contribute to reduced survival.
Title: Skin injuries reduce survival and modulate corticosterone, C-reactive protein, complement component 3, IgM, and prostaglandin E 2 after whole-body reactor-produced mixed field (n + γ-photons) irradiation.
Emu-myc mice provide a model to study spontaneous regression and possible mechanisms of immune evasion or suppression by cancer cells.
Title: ATM-dependent spontaneous regression of early Eμ-myc-induced murine B-cell leukemia depends on natural killer and T cells.
Coronavirus-induced demyelinating CNS disease can be efficiently prevented by a long-lasting germline-encoded IgM response.
Title: T helper cell- and CD40-dependent germline IgM prevents chronic virus-induced demyelinating disease.
Core fucosylation of mu heavy chains regulates assembly and intracellular signaling of precursor B cell receptors.
Title: Core fucosylation of μ heavy chains regulates assembly and intracellular signaling of precursor B cell receptors.
deficiencies in B-cell development increase with increased transgene copy number
Title: Excessive amounts of mu heavy chain block B-cell development.
The critical importance of pre-BCR and BCR receptor levels for the normal development of B-lymphocyte subpopulations in the context of intact VDJ recombination and a diverse antibody repertoire.
Title: A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (16) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI326478 (e-PCR)
- UniSTS:180487

PMC312773P1 (e-PCR)
- UniSTS:272917

UniSTS:461920 (e-PCR)
- UniSTS:461920

Igh-6 (e-PCR), detects polymorphism
- UniSTS:461920

Igh (e-PCR), detects polymorphism
- UniSTS:143493

PMC124510P1 (e-PCR)
- UniSTS:270472

Igh-6 (e-PCR), detects polymorphism
- UniSTS:143498

PMC305257P2 (e-PCR)
- UniSTS:272540

D12Mit8 (e-PCR), detects polymorphism
- UniSTS:126899

M-04725 (e-PCR)
- UniSTS:186305

NoName (e-PCR)
- UniSTS:224213

Other Names

Ig mu
immunoglobulin heavy chain 6 (heavy chain of IgM)
mu-immunoglobulin

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables antigen binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables immunoglobulin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables immunoglobulin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to immunoglobulin receptor binding	ISO Inferred from Sequence Orthology more info
contributes_to peptidoglycan binding	ISO Inferred from Sequence Orthology more info
contributes_to phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of B cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within B cell affinity maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of B cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within antigen processing and presentation	IDA Inferred from Direct Assay more info
involved_in complement activation, classical pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within early endosome to late endosome transport	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within immunoglobulin mediated immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of B cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of B cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of endocytosis	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within positive regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in pre-B cell allelic exclusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of B cell receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of IgM B cell receptor complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of hexameric IgM immunoglobulin complex	ISO Inferred from Sequence Orthology more info
part_of immunoglobulin complex, circulating	IBA Inferred from Biological aspect of Ancestor more info
part_of immunoglobulin complex, circulating	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
part_of pentameric IgM immunoglobulin complex	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.