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    Cul9 cullin 9 [ Mus musculus (house mouse) ]

    Gene ID: 78309, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cul9provided by MGI
    Official Full Name
    cullin 9provided by MGI
    Primary source
    MGI:MGI:1925559
    See related
    Ensembl:ENSMUSG00000040327 AllianceGenome:MGI:1925559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Parc; Cul-9; mKIAA0708; 1810035I07Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; metal ion binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in microtubule cytoskeleton organization; protein ubiquitination; and regulation of mitotic nuclear division. Predicted to be located in cytosol. Predicted to be part of cullin-RING ubiquitin ligase complex. Is expressed in several structures, including brain; retina nuclear layer; and testis. Orthologous to human CUL9 (cullin 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.3), adrenal adult (RPKM 12.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 C; 17 22.9 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46811535..46857314, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46500609..46546388, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42667 Neighboring gene tau tubulin kinase 1 Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Neighboring gene STARR-positive B cell enhancer ABC_E7535 Neighboring gene microRNA 6976 Neighboring gene serum response factor Neighboring gene PTK7 protein tyrosine kinase 7 Neighboring gene VISTA enhancer mm1620 Neighboring gene STARR-seq mESC enhancer starr_42674 Neighboring gene STARR-seq mESC enhancer starr_42675

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of a Cul9-Parkin double knockout mouse model for Parkinson's disease. Hollville E, et al. Sci Rep, 2020 Oct 9. PMID 33037272, Free PMC Article
    2. Cullin9 protects mouse eggs from aneuploidy by controlling microtubule dynamics via Survivin. Dai X, et al. Biochim Biophys Acta, 2016 Dec. PMID 27678504
    3. Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53. Li Z, et al. Oncogene, 2017 Sep 7. PMID 28481879, Free PMC Article
    4. Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis. Pei XH, et al. Cancer Res, 2011 Apr 15. PMID 21487039, Free PMC Article
    5. Identification of far upstream element-binding protein-1 as an authentic Parkin substrate. Ko HS, et al. J Biol Chem, 2006 Jun 16. PMID 16672220

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of a Cul9-Parkin double knockout mouse model for Parkinson's disease.
      Title: Characterization of a Cul9-Parkin double knockout mouse model for Parkinson's disease.
    2. The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
      Title: Cullin9 protects mouse eggs from aneuploidy by controlling microtubule dynamics via Survivin.
    3. A 3M-CUL9-survivin pathway is implicated in maintaining microtubule and genome integrity, normal development, and tumor suppression.
      Title: CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.
    4. Dimerization of Cul7 and Parc is not required for all Cul7 functions and mouse development.
      Title: Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development.
    5. FUBP1 is an authentic substrate of Parkin that might play an important role in development of Parkinson disease pathology along with aminoacyl-tRNA synthetase interacting multifunctional protein type 2
      Title: Identification of far upstream element-binding protein-1 as an authentic Parkin substrate.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cullin-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cullin-9
    Names
    p53-associated parkin-like cytoplasmic protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081335.2 → NP_001074804.2  cullin-9

      Status: VALIDATED

      Source sequence(s)
      AK051474, AK147675, AK162968, BP753198, CF534354, CJ110581
      Consensus CDS
      CCDS37636.2
      UniProtKB/TrEMBL
      E9QP09, S4R1Y1
      Related
      ENSMUSP00000138418.2, ENSMUST00000182485.8
      Conserved Domains (7) summary
      COG5647
      Location:1694 → 1947
      COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cl02148
      Location:1169 → 1299
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      pfam00888
      Location:1597 → 1815
      Cullin; Cullin family
      pfam11515
      Location:367 → 441
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cd20347
      Location:2150 → 2223
      BRcat_RBR_CUL9; BRcat domain found in cullin-9 (CUL-9) and similar proteins
      cd20359
      Location:2231 → 2288
      Rcat_RBR_CUL9; Rcat domain found in cullin-9 (CUL-9) and similar proteins
      cl17238
      Location:2072 → 2124
      RING_Ubox; RING finger (Really Interesting New Gene) domain and U-box domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46811535..46857314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246723.4 → XP_011245025.1  cullin-9 isoform X2

      UniProtKB/TrEMBL
      E9QP09
      Conserved Domains (8) summary
      smart00647
      Location:2183 → 2245
      IBR; In Between Ring fingers
      COG5647
      Location:1732 → 1985
      COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd00162
      Location:2112 → 2162
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam00888
      Location:1736 → 1852
      Cullin; Cullin family
      pfam01485
      Location:2276 → 2311
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:382 → 456
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cl02148
      Location:1184 → 1314
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl17238
      Location:2111 → 2162
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_011246722.4 → XP_011245024.1  cullin-9 isoform X1

      UniProtKB/TrEMBL
      E9QP09
      Conserved Domains (8) summary
      smart00647
      Location:2187 → 2249
      IBR; In Between Ring fingers
      COG5647
      Location:1736 → 1989
      COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd00162
      Location:2116 → 2166
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam00888
      Location:1740 → 1856
      Cullin; Cullin family
      pfam01485
      Location:2280 → 2315
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:382 → 456
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cl02148
      Location:1184 → 1314
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl17238
      Location:2115 → 2166
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. XM_006525135.5 → XP_006525198.1  cullin-9 isoform X3

      UniProtKB/TrEMBL
      E9QP09
      Related
      ENSMUST00000182315.8
      Conserved Domains (8) summary
      smart00647
      Location:2160 → 2222
      IBR; In Between Ring fingers
      COG5647
      Location:1709 → 1962
      COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd00162
      Location:2089 → 2139
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam00888
      Location:1612 → 1829
      Cullin; Cullin family
      pfam01485
      Location:2253 → 2288
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:382 → 456
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cl02148
      Location:1184 → 1314
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl17238
      Location:2088 → 2139
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    4. XM_006525136.5 → XP_006525199.1  cullin-9 isoform X4

      UniProtKB/TrEMBL
      E9QP09
      Conserved Domains (8) summary
      smart00647
      Location:2160 → 2222
      IBR; In Between Ring fingers
      COG5647
      Location:1709 → 1962
      COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd00162
      Location:2089 → 2139
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam00888
      Location:1612 → 1829
      Cullin; Cullin family
      pfam01485
      Location:2253 → 2288
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:382 → 456
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cl02148
      Location:1184 → 1314
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      cl17238
      Location:2088 → 2139
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80TT8.2 GenPept UniProtKB/Swiss-Prot:Q80TT8

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